University of Groningen RPPA-profiling in pediatric acute leukemia: pattern recognition and therapeutic guidance Hoff, Fieke

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University of Groningen

RPPA-profiling in pediatric acute leukemia: pattern recognition and therapeutic guidance

Hoff, Fieke

DOI:

10.33612/diss.168765254

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Hoff, F. (2021). RPPA-profiling in pediatric acute leukemia: pattern recognition and therapeutic guidance. University of Groningen. https://doi.org/10.33612/diss.168765254

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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A

B

C

GO Biological Process 0 2 4 6 8 10

Negative regulation apoptotic process Germ cell development Intrinsic apoptotic signaling pathway in response to DNA damage Positive regulation of protein lacalization to nucleus Transforming growth factor beta receptor signaling pathway Protein autophosphorylation Extrinsic apoptotic signaling pathway in absence of ligand Negative regulation of apoptotic process Cellular response to hypoxia Cell proliferation Intrinsic apoptotic signaling pathway in response to DNA damage Cell proliferation

Number of proteins GO Biological Process

0 2 4 6 8 10

Negative regulation apoptotic process Germ cell development Intrinsic apoptotic signaling pathway in response to DNA damage Positive regulation of protein lacalization to nucleus Transforming growth factor beta receptor signaling pathway Protein autophosphorylation Extrinsic apoptotic signaling pathway in absence of ligand Negative regulation of apoptotic process Cellular response to hypoxia Cell proliferation Positive regulation of transcription from RNA polymerase II

promotor

Intrinsic apoptotic signaling pathway in response to DNA damage Cell proliferation

0 2 4 6 8 10

Number of proteins

0 2 4 6 8 10

(12)

!W!+,-.'#/!4! ?B!

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!

X6! #&;7&! *#! 7<*:@9'<)! B97:6! B799! BA9*A&7<! *#! ?:Q7! B799! 9'67! 7U$7&'?76*<! ?#&7! &79':@97! :6;! &7$&#;AB'@974!C7!<*&#6(9%!76B#A&:(7!*)7!&7(A9:&!*7<*'6(!#3!B799!BA9*A&7<!3#&!?%B#$9:<?:!:6;!*#! *&7:*!B799!9'67<!'3!BA9*A&7<!*7<*!$#<'*'>7!*#!:>#';!):>'6(!*)7!B#6<7[A76B7<!#3!:9*7&7;!7U$&7<<'#6! #3! *)7<7! $&#*7'6<! B#63#A6;'6(! *)7! 7U$7&'?76*:9! &7<A9*<0! j7*4! :<! 37C! :9*7&:*'#6<! &7?:'67;! @7*C776! *)7! $#<*S*&7:*?76*! <:?$97<! :6;! *)7! 67>7&S'637B*7;! <:?$97<! '6! #A&! B#)#&*4! :6;! :<! B):6(7<!'6!$&#*7'6!7U$&7<<'#6!C7&7!#@<7&>7;!:3*7&!*&7:*?76*!#3!67>7&S'637B*7;!B799<4!:;;'*'#6:9! B799!BA9*A&'6(!3#&!?#&7!*):6!*C#!C77Q<!:3*7&!B#?$97*'#6!#3!*)7!:6*'@'#*'B!*&7:*?76*4!#&!*:Q'6(!:! B97:6!B799!9'67!:9'[A#*4!<)#A9;!:9<#!@7!B#6<';7&7;0!! ! +-:,$R4'8;'%',&(! ! 8#!3A6;'6(!*#!;7B9:&70!! ! )$,54.-&!$5!.,&'#'(&!! ! Y)7!:A*)#&<!;7B9:&7!6#!B#?$7*'6(!'6*7&7<*<0! ! @;3(.8-)7-!%&$#3'%(&!-8'#/)!./('#%&!#A./#))%(&!W!??! ! ! A*12$(! 6[! I(5(! '5%'0'1=! (5$*+.)(5%! #5#0=,*,! 3'$! %.(! ,*15*3*+#5%0=! #0%($(/! 4$'%(*5,F! d-/! 9/-.,! ),(I%&9!',#!)%9&%$%3-&'8;!#&/%3,#1!d%(8(9%3-8!M/(3#))#)!$(/!KDL!CC!./('#%&)!',-'!I#/#!-8'#/#1!:#'I##&! ',#!%&$#3'#1!-&1!&#<#/S%&$#3'#1!3#88!328'2/#!)-7.8#)X!KML!',#!44!./('#%&)!',-'!I#/#!3,-&9#1!:#'I##&!',#! %&$#3'#1!-&1!.()'S'/#-'7#&'!)-7.8#)X!-&1!K<L!$(/!',#!*N!./('#%&)!',-'!I#/#!-8'#/#1!%&!:(',!',#!&#<#/S %&$#3'#1!-&1!',#!.()'!'/#-'7#&'!)-7.8#)!%&!3(7.-/%)(&!'(!',#!%&$#3'#1!3#88)[!d%(8(9%3-8!./(3#))#)!I%',! -&!R"GS3(//#3'#1!qS<-82#!y!H[HF!I#/#!3(&)%1#/#1!)%9&%$%3-&'[! !

A

B

C

GO Biological Process 0 2 4 6 8 10

0 2 4 6 8 10

Negative regulation apoptotic process Germ cell development Intrinsic apoptotic signaling pathway in response to DNA damage Positive regulation of protein lacalization to nucleus Transforming growth factor beta receptor signaling pathway Protein autophosphorylation Extrinsic apoptotic signaling pathway in absence of ligand Negative regulation of apoptotic process Cellular response to hypoxia Cell proliferation Positive regulation of transcription from RNA polymerase II

promotor

Intrinsic apoptotic signaling pathway in response to DNA damage Cell proliferation

0 2 4 6 8 10

Number of proteins

0 2 4 6 8 10

(13)

!W!+,-.'#/!4! ?E! <'5'#',-'!4.(&!! ! *[! "/#A8#/! OLX! "%/>)! fLX! @-3V#(1! GDX! r.,($$! ++[! R-8)#! -&1! 7;3(.8-)7-S 3(&'-7%&-'#1!8#2>#7%-S8;7.,(7-!3#88!8%&#)=! '%7#! $(/! -! /#-../-%)-8[! 6$(# B# '.$?")[! 5H*?\*CHPFT=*5HNS*5*C[! 5[! "/#A8#/! OLX! r.,($$! ++[! @;3(.8-)7-! 3(&'-7%&-'%(&! ($! 3#88! 328'2/#)=! 0&3%1#&3#X! )(2/3#)X! #$$#3')X! 1#'#3'%(&X! #8%7%&-'%(&X! ./#<#&'%(&[! '0(%("?1$%/%;0[! 5HH5\4NP5T=?FS NH[! 4[! r.,($$! ++X! "/#A8#/! OL[! +(7.-/-'%<#! -&'%:%('%3! #/-1%3-'%(&! ($! 7;3(.8-)7-! %&$#3'%(&)!$/(7!3(&'%&2(2)!3#88!8%&#)[!6$#U*()%# '"//#L"&#@*%/#D$*7[!5HH5\4EP5T=EBSEN[! C[! b%>$-/Y-7! VX! R-/U-&#,! M[! M/#<#&'%(&! -&1!

1#'#3'%(&! ($! @;3(.8-)7-! 3(&'-7%&-'%(&! %&! 3#88!328'2/#[!'"//#B[!5H*5\*4PCT=5H4S5*5[! F[! G(''#7! QX! d-/%8#! @R[! d#I-/#! ($! 7;3(.8-)7-)[! K)"$!># @*%("?1$%/[! *NN4\**PCT=*C4S*F*[! B[! @%88#/!+hX!Z-))#7!OQX!M#..#/!Q"X!O#;!cX! f-/1! 6OX! @-/9%)(&! LM[! @;3(.8-)7-! %&$#3'%(&!)%9&%$%3-&'8;!-8'#/)!7%3/(-//-;!9#&#! #A./#))%(&! ./($%8#)[! @*%K"?1$*-,">8! 5HH4\4FP4T=E*5SE*C[! ?[! ^,-&9! QX! f#-/! "hX! V(! Q[! @;3(.8-)7-8! %&$#3'%(&)! -8'#/! 9#&#! #A./#))%(&! %&! 328'2/#1! ,27-&!./()'-'%3!-&1!3#/<%3-8!#.%',#8%-8!3#88)[!

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