The tissue factor pathway in pneumonia

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van den Boogaard, F.E.

Publication date

2015

Document Version

Final published version

Link to publication

Citation for published version (APA):

van den Boogaard, F. E. (2015). The tissue factor pathway in pneumonia.

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Floor van den Boogaard

The tissue factor

pathway in

pneumonia

The tissue factor pathway in pneumonia |

Floor van den Boogaard

The tissue factor pathway in pneumonia

Since the respiratory tract is in continuous contact with the

external environment, it is particularly prone to invading

pathogens. Pneumonia is a major cause of morbidity worldwide

with substantial mortality. Emerging bacterial resistance and

stagnation of mortality rates urge us to expand our knowledge

of the host response against bacteria, in the quest to develop

alternative treatment strategies.

Inflammation and coagulation are two important host defence

mechanisms that interact to mount an adequate immune

response against infectious agents. This thesis presents

experimental studies focused on the role of coagulation

induced by the tissue factor pathway in the immune

response against bacterial pneumonia.