Antiretroviral therapy in Thai adults and children with HIV-1 infection - Chapter 6: Incidence and risk factors for rash in Thai patients randomized to regimens with nevirapine, efavirenz or both drugs
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(277) 95; >=A32 / 5@3/B3@ @7A9 4=@ @/A6 4@=; ""&( $3@A=<A =4 A;/:: AB/BC@3 AC16 /A (6/7A ;/G 03 >@327A>=A32 B= 6/D7<5 6756 2@C5 :3D3:A 2C@7<5 AB/<2/@2 2=A7<5 =4 /<B7@3B@=D7@/: 2@C5A +3 6/D3 A6=E< (6/7 >/B73<BA B= 6/D3 67563@ :3D3:A =4 @7B=</D7@0==AB32. A/?C7</D7@ B6/< /C1/A7/<A /<2 :/19A - . D3< 74 B67A 6=:2A B@C3 4=@ ""&( 7B 7A AB7:: C<9<=E< E63B63@ 67563@ ""&( >:/A;/ 1=<13<B@/B7=<A 1=@@3:/B3 E7B6 @/A6 =11C@@3<13 - . (63 4/1B B6/B =C@ >/B73<BA E7B6 67563@ ! E3@3 /B ;=@3 @7A9 4=@ @/A6 1=<B@/271BA B67A < 7<1@3/A32 7<1723<13 /<2 A3D3@7BG =4 "*$ 6G>3@A3<A7 B7D7BG 7< E=;3< 3A>317/::G 2C@7<5 >@35</<1G 6/A 033< @3>=@B32 *7@/;C<3 >/19/53 7<A3@B =36@7<53@ <53: 637; $6/@;/13CB71/:A <1 &7253I3:2 =<<31B71CB )' - . +=;3< /:A= 6/D3 / 67563@ 7<1723<13 =4 @/A6 4@=; =B63@ /<B7@3B@=D7@/: 2@C5A - . < =C@ ABC2G E=;3< E7B6 0/A3:7<3 13:: 1=C<B 13::A: E3@3 ;=@3 :793:G B= 6/D3 @/A6 /<2 4=C@ =4 A7F >/B73<BA E7B6 A3@7=CA /2D3@A3 3D3<BA E3@3 E=;3< +63B63@ B67A 7A 2C3 B= / 6=@;=</: 34431B =@ 53<23@@3:/B32 27443@3<13A 7< 1GB=16@=;3 $ ;3B/0=:7A; =@ 0=2G A7H3 7A <=B 9<=E< $@3D7=CA @3>=@BA 6/D3 AC553AB32 B6/B >3@A=<A E7B6 / 67563@ 0/A3:7<3 13:: 1=C<B /@3 :793:G B= 23D3:=> @/A6 4@=; "*$ - . < =C@ /</:GA7A / 13:: 1=C<B 13::A: E/A /AA=17/B32 E7B6 / 67563@ @7A9 0CB =<:G 7< E=;3< =E3D3@ >3@A=<A E7B6 E3@3 ;=@3 :793:G B= 6/D3 @/A6 /<2 >/B73<BA 7< B63 * /<2 B63 "*$ /@;A E6= =D3@/:: 6/2 / ;C16 :=E3@ 0/A3:7<3 13:: 1=C<B /<2 ;=@3 /2D/<132 * 27A3/A3 23D3:=>32 :3AA @/A6 AA3<B7/::G B63 3D723<13 >=7<BA B=E/@2A / 5@3/B3@ @7A9 =4 ""&( @3:/B32 @/A6 7< >3@A=<A E7B6 03BB3@ >@3A3@D32 7;;C<3 4C<1B7=< (63 ;316/<7A; =4 ""&( @3:/B32 @/A6 7A C<1:3/@ C@@3<B /<7;/: /<2 6C;/< 2/B/ AC553ABA / 13::;327/B32 7;;C<3 ;316/<7A; -
(278) . (63 :=E3@ @7A9 =4 @/A6 7< >/B73<BA E7B6 :=E3@ 13:: 1=C<B 7A 1=<A7AB3<B E7B6 =B63@ @3>=@BA AC553AB7<5 / ;316/<7A; =4 7;;C<3 B=:3@/<13 7< B6=A3 E7B6 / 67563@ 235@33 =4 7;;C<=23I173<1G - . #C@ >/B73<BA E6= 6/2 / @/>72 @31=D3@G E3@3 /B / 67563@ @7A9 4=@ 23D3:=>7<5 @/A6 (67A 7A A7;7:/@ B= B6=A3 E6= /@3 /B @7A9 4=@ 7;;C<3 @31=<AB7BCB7=< AG<2@=;3 -
(279) . +3 6G>=B63A7H3 B6/B B63 @/>72 @3D3@A/: =4 7;;C<3 2GA4C<1B7=< 1/CA32 /< 7;;C<3 @3A>=<A3 B=E/@2A ""&( /<B753<A /<2 ;/<743AB32 7BA3:4 7< @/A6 /<2 3:3D/B32 ( B6<717BG 6/A /:A= 033< @3>=@B32 B= 03 / @7A9 4/1B=@ /:B6=C56 B67A @3;/7<A 1=<B@=D3@A7/: 67563@ 7<1723<13 =4 "*$/AA=17/B32 @/A6 E/A @3>=@B32 7< 7A>/<71A - . < / A;/:: 1=6=@B =4 67<3A3 ID3 =4 3756B 6/2 @/A6 4@=; "*$ -. #C@ >/B73<BA 6/2 / 67563@ 7<1723<13 =4 ""&( @3:/B32 @/A6 =<:G 74 "*$ # /<2 "*$ * E3@3 CA32 (63 7;>=@B/<13 =4 67AB=1=;>/B707:7BG :3C9=1GB3 /<B753<A 7< B63 >/B6=53<3A7A =4 6G>3@A3<A7B7D7BG 6/A 033< 23;=<AB@/B32 4=@ /0/1/D7@ /<2 =B63@ 2@C5A - . C@B63@ ABC273A B6/B 1/@34C::G 3F/;7<3 /<2 @3:3D/<B 3>7B=>3A E=C:2 63:> 23B3@;7<3 B63 C<23@:G7<5 ;316/<7A;A =4 ""&( 6G>3@A3<A7B7D7BG < 1=<1:CA7=< =C@ >=>C:/B7=< 6/2 / 67563@ 7<1723<13 =4 ""&( @3:/B32 @/A6 B6/< ;=AB >C0:7A632 1=6=@BA 272 E63< B@3/B32 E7B6 "*$ # /<2 "*$ * 0CB <=B.
(280) >«ÌiÀÊÈ\Ê ÊÀiÃÃÌ>ViÊÜÌ ÊÃ>µÕ>ÛÀÉÀÌ>ÛÀÊv>ÕÀiÊ. E7B6 "*$ =@ * /:=<3 4 CA32 "*$ 272 <=B 1/CA3 ;=@3 @/A6 B6/< * +=;3< E7B6 13:: 1=C<B 13::A: /<2 B6=A3 E7B6 0/A3:7<3 /<2 67563@ ! E3@3 ;=@3 :793:G B= 23D3:=> @/A6 @7A3 7< 13:: 1=C<B /<2 B@/<A/;7</A3A E339A /4B3@ B@3/B;3<B E3@3 @7A9 4/1B=@A 4=@ ""&( @3:/B32 @/A6. +367?4-,/-5-6< +3 /@3 5@/B34C: B= @ !/BB63E @35/@27<5 B63 AB/B7AB71/: /</:GA7A. /E 4=@ 67A /2D713. $#"'#&' $ '()- +' )" - # & " & " !. "-.-:-6+-; &@==2C5 ( (@3:?D@? & C2?DL6=5 ! #).-<A 8:7C4- 7. 6->1: )816- ) 6766=+4-7;1,- :->-:;- <:)6;+:18<);- 1601*1<7: .7: <0<:-)<5-6< 7. 0=5)6 155=67,-C+1-6+A >1:=; 16.-+<176 " & M
(281)
(282) 2CC6:C@ & )@C:2?@ , 2D2D DEC252 , *6==6K # @6E6= >2?D ( ( !:->-6<176 7. 6->1:)816-);;7+1)<-, -@)6<0-5) =;16/ ;47? ,7;- -;+)4)<176 )6,7: +7:<1+7;<-:71,;
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(294).
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(298). M 2G=:C 966D6>2? ) #4"2F89=:? # #FCA9J ( C:46 )A64E@C ) ( 1/0,7;- 6->1:)816- ;).-<A 80):5)+731 6-<1+; )6, )6<1>1:)4 -..-+< 16 8)<1-6<; ?1<0 0=5)6 155=67 ,-C+1-6+A >1:=; 16.-+<176
(299) "( ' M. ?E:?@C: 2=5:?: :C2C5: :?8@=2?: /2442C6==: # : :2>36?656EE@ ) ( -5)4- ;-@ )6, <0- =;- 7. )6<1)44-:/1+ )/-6<; 16+:-);- <0- :1;3 7. ,->-47816/ +=<)6-7=; :);0 );;7 +1)<-, ?1<0 6->1:)816- <0-:)8A
(300). M @KK:"6AC: &9:==:AD $ 5C>:?:@ #@?7@CE6 &:6CD2?E6==: $ %C2?: &6EC@D:==@ $ ( &1:747/1+ )6, 155=6747/1+ :-;876;- <7 :-/15-6; +76<)1616/ 6->1:)816- 7: -.)>1:-6B 16 +75*16)<176 ?1<0 6=+4-7;1,- )6)47/=-; 16 <0- <)41)6. xx. 707:< )1>- 6<1:-<:7>1:)4; 7 ;<=,A
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(306) M )E2DK6HD<: ) #@C2=6D(2>:C6K *2D9:>2 !* (249=:D )<:6DE )E2?7@C5 ( .)>1:-6B 84=; B1,7>=,16- )6, 4)51>=,16- -.)>1:-6B 84=; 16,16)>1: )6, 16,16)>1: 84=; B1,7>=,16- )6, 4)51>=,16- 16 <0- <:-)<5-6< 7. & 16.-+<176 16 ),=4<; #<=,A $-)5 "
(307)
(308) M 2EE6=2? # *C6G6?K@=: # )2DD6E " )82C23@EE@ "2?K272>6 # #6?6896EE: $7@1+ -81,-:5)4 6-+:74A;1; 16,=+-, *A 6->1:)816- <0-:)8A ,-;+:18<176 7. <?7 +);-; )6, :->1-? 7. <0- 41<-:)<=:-
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(312) M
(313) FE2C () ?2?H@C2?:49 A2E66C2A@?8 - )2?<@E6 :== :CD496= ( !0):5)+7316-<1+ ;<=,A 7. ;)9=16)>1: 0):, /-4 +)8;:1<76)>1: 16 & 16.-+<-, 8)<1-6<; 5/ 76+- ,)14A +758):-, ?1<0 5/ 76+-,)14A )6, 5/ <?1+-,)14A
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(317).
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(319) #6ECJ - "292CE 2C>6C !" 636CE #<->-6;706;76 ;A6,:75- +)=;-, *A <0- )6<1:-<:7>1:)4 ,:=/ 6->1:)816-
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(322)
(323) M 6CD@77#2E492 ) #:==6C - 36C8 G2? 56C @CDE 2>C:4< C &@H56C=J - ( #-@ ,1..-:-6+-; 16 6->1:)816- :);0 " "( '
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(326) #2K9F56 @?6D ) #FC25 ) *2J=@C 2DE6C3C@@< & -5)4;-@ *=< 67< -<061+1<A 1; ) ;<:76/ 8:-,1+<7: 7. 6766=+4-7;1,:->-:;- <:)6;+:18<);- 1601*1<7:16,=+-, :);0
(327).
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(329) =@C:5:2 # F44:2C5:?: ( C28@=2 , 2==FKK@ # :2??:?: &:C:==@ # ( "1;3 .)+<7:; )6, 7++=::-6+- 7. :);0 16 & 87;1<1>- 8)<1-6<; 67< :-+-1>16/ 6766=+4-7;1,- :->-:;- <:)6 ;+:18<);- 1601*1<7: ,)<) .:75 ) :)6,751B-, ;<=,A ->)4=)<16/ =;- 7. 8:7<-);- 1601*1<7:; 16 6=+4-7;1,--@8-:1-6+-, 8)<1-6<; ?1<0 >-:A 47?
(330) 4->-4; +-44;51+:7
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(332) 2F>6D F6C>@?AC6K "64@>E6 !2E=2>2 C:42:C6 .C+)+A )6, ;).-<A 7. ,-;-6;1<1B)<176 ?1<0 ;=4.)5-<07@)B74)6, <:15-<078:15 16
(333) 8:->17=;4A 0A8-:;-6;1<1>- 8)<1-6<; 16.-+<-, ?1<0 0=5)6 155=67,-C+1-6+A >1:=; & &!(# M
(334)
(335) )96?E@? # *6C2?:D9: # 3FD23 #) .286C +6EC649E & 0):)+<-:1B)<176 7. ) 87<-6<1)4 )615)4 57,-4 7. )6 1,17;A6 +:)<1+ ,:=/ :-)+<176 6->1:)816-16,=+-, ;316 :);0 16 <0- :)< ! ' #, #
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