Cover Page
The handle
http://hdl.handle.net/1887/139202
holds various files of this Leiden
University dissertation.
Author: Helm, D. van der
Title: Towards treatment of liver fibrosis: Cells, targets and models
Issue date: 2021-02-11
Towards treatment of liver fibrosis;
cells, targets and models
Copyright © 2020 Danny van der Helm. All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers.
ISBN: 978-94-6423-074-1
Design, Lay-out and Printing: ProefschriftMaken
The printing of this thesis was financially supported by: Nederlandse Vereniging voor Gastroenterologie (NVGE) and Sectie Experimentele Gastroenterologie (SEG)
Towards treatment of liver fibrosis;
cells, targets and models
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. dr. ir. H. Bijl,
volgens besluit van het College voor Promoties te verdedigen op donderdag 11 februari 2021
klokke 13:45 uur
Door Danny van der Helm
Promotoren: Prof. dr. ir. H.W. Verspaget Prof. dr. B. van Hoek Co-promotor: Dr. M.J. Coenraad Promotiecommissie: Prof. dr. P.S. Hiemstra
Prof. dr. I.P.J. Alwayn Prof. dr. B.E. Snaar-Jagalska
Prof. dr. M.E.J. Reinders (Erasmus MC) Dr. M.J. Hoogduijn (Erasmus MC)
Table of Contents
Chapter 1 General Introduction 7
Chapter 2 Local but not systemic administration of mesenchymal stromal
cells ameliorates fibrogenesis in regenerating livers 27
Chapter 3 VCAM-positive mesenchymal stromal cells are most
instrumental in ameliorating experimental liver fibrogenesis 55
Chapter 4 Mesenchymal stromal cells prevent progression of liver fibrosis
in a novel zebrafish embryo model 77
Chapter 5 Local and systemic elevated Cripto levels during liver fibrogenesis 101 Chapter 6 CRIPTO promotes an aggressive tumour phenotype and
resistance to treatment in hepatocellular carcinoma 119
Chapter 7 General Discussion 153
Appendix Nederlandse samenvatting 170
Curriculum vitae 175
Publications 176
