Tracing T cell differentiation by genetic barcoding
Heijst, J.W.J. van
Citation
Heijst, J. W. J. van. (2010, June 24). Tracing T cell differentiation by genetic barcoding.
Retrieved from https://hdl.handle.net/1887/15721
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/15721
Note: To cite this publication please use the final published version (if applicable).
Tracing T cell differentiation
by genetic barcoding
Tracing T cell differentiation by genetic barcoding
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 24 juni 2010 klokke 11.15 uur
door
Jeroen Waltherus Johannes van Heijst
geboren te Tilburg in 1981
Promotiecommissie
Promotor: Prof. Dr. T.N.M. Schumacher
Overige leden: Prof. Dr. C.J.M. Melief Prof. Dr. T.H.M. Ottenhoff
Prof. Dr. R.A.W. van Lier (Universiteit van Amsterdam) Prof. Dr. J. Borst (Universiteit van Amsterdam)
Dr. H. Jacobs (NKI-AVL) Dr. B. van Steensel (NKI-AVL)
Voor mijn ouders, voor Daniëlle
The studies described in this thesis were performed at the Division of Immunology at the Netherlands Cancer Institute (NKI), Amsterdam, the Netherlands.
The printing of this thesis was financially supported by the Netherlands Cancer Institute and Leiden University.
Contents
Chapter 1: Introduction and scope of this thesis 9
Chapter 2: Mapping the life histories of T cells 19
Nature Reviews Immunology (Invited)
Chapter 3: Dissecting T cell lineage relationships by cellular barcoding 37 J. Exp. Med. 205: 2309-2318 (2008)
Chapter 4: One naïve T cell, multiple fates in CD8+ T cell differentiation 57 J. Exp. Med. (In press)
Chapter 5: Effector and memory lineage decision occurs after naïve 81 T cell priming
Unpublished
Chapter 6: Recruitment of antigen-specific CD8+ T cells in response to 95 infection is markedly efficient
Science 325:1265-1269 (2009)
Chapter 7: Tracing cellular origins by inducible DNA diversification 113 in vivo
Unpublished
Chapter 8: Summary and discussion 129
Nederlandse samenvatting 143
Curriculum Vitae 151
List of publications 153
