Therapeutic and imaging potential of peptide agents in cardiocascular
disease
Yu, H.
Citation
Yu, H. (2007, June 21). Therapeutic and imaging potential of peptide agents in cardiocascular disease. Retrieved from https://hdl.handle.net/1887/12090
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Therapeutic and Imaging Potential of
Peptide Agents in Cardiovascular Disease
Therapeutic and Imaging Potential of
Peptide Agents in Cardiovascular Disease
PROEFSCHRIFT ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. Mr. P.F.van der Heijden, hoogleraar in de faculteit der Wiskunde en
Natuurwetenschappen en die der Geneeskunde, volgens besluit van het College voor Promoties
te verdedigen op Donderdag 21 June 2007 klokke 13.45 uur
door
Haixiang Yu
geboren te Baotou, Inner Mongolia, China On Nov 26 1976
Promotiecommissie
Promotor: Prof. Dr. Erik. A.L. Biessen Prof. Dr. Theo. J. C. Van Berkel Referent: Dr. Leon de Windt
Overige leden: Prof. Dr. Meindert Danhof Prof. Dr. Herman Overkleeft
Dr. Sylvia Heeneman
The studies presented in this thesis were performed in the Division of Biopharmaceutics of the Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, the Netherlands
The study presented in this thesis was financially supported by the Dutch Technology Foundation STW project LFA.5952. Financial support by the STW for the publication of this thesis is gratefully acknowledged.
Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged
The printing of this thesis was also financially supported by -LACDR
-Tebu-bio BV -Corning BV
To my father Yu Shuhe, mother Yao Meiling and my wife Huang Yanchao
Cover: landscape of Leiden, the Netherlands, photographed by Haixiang Yu Printing by: Gildeprint Drukkerijen, Enschede, the Netherlands
ISBN/EAN: 978-90-9021922-6 Haixiang Yu
Therapeutic and Imaging Potential of Peptide Agents in Cardiovascular Disease
Proefschrift Leiden – Met lit. opgave – Met samenvatting in het Nederlands
© 2007 Haixiang Yu
No part of this thesis may be reproduced or transmitted in any form or by any means, without written permission of the author.
Table of Contents
Page Chapter 1 General introduction
9 Chapter 2 Therapeutic Potential of VIVIT, a Selective Peptide
Inhibitor of Nuclear Factor of Activated T cells, in Cardiovascular Disorders
33
Chapter 3 Atherosclerosis Imaging Potential of a Novel Peptide Ligand selective for SR-AI
47
Chapter 4 Targeting CD40 with a Selective Phage Display Derived Peptide
61
Chapter 5 Therapeutic Potential of a Synthetic Peptide Inhibitor of NFAT as Anti-restenotic Agent
75
Chapter 6 Potent Bipartite Inhibitors of Nuclear Factor of Activated T-Cells with Superior Selectivity Compared with Cyclosporin A
93
Chapter 7 General Discussion and Summary 115
Chapter 8 Nederlandse Samenvatting 123
Abbreviations 127
Publication list 129
Curriculum Vitae 131
Appendix-color figures 133
