University of Groningen
Circulating microRNAs in heart failure
Vegter, Eline Lizet
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Publication date: 2017
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Vegter, E. L. (2017). Circulating microRNAs in heart failure. Rijksuniversiteit Groningen.
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Circulating microRNAs in heart failure
Circulating microRNAs in heart failure ISBN: 978-94-9268-392-2
© Copyright 2017 - E.L. Vegter
All rights are reserved. No part of this publication may be reproduced, stored in a re-trieval system, or transmitted in any form or by any means, without the written permis-sion of the author.
The financial support of the Graduate School of Medical Sciences and the University of Groningen for the publication of this thesis is gratefully acknowledged.
Cover design: Sara ten Broeke en Rik Vegter
Circulating microRNAs
in heart failure
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 18 oktober 2017 om 14.30 uur
door
Eline Lizet Vegter
geboren op 27 december 1988 te Venlo
Promotor
Prof. dr. A.A. Voors
Copromotor
Dr. P. van der Meer
Beoordelingscommissie
Prof. dr. J. van der Velden Prof. dr. L.J. de Windt Prof. dr. M.P. van den Berg
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged. The research described in this thesis was supported by a grant from the Dutch Heart Foundation (CVON 2011-11).
Paranimfen
Dr. J.C. Tanis Drs. L.V. de Vries
TABLE of CoNTENTs
Chapter 1 Introduction and aims 9 Chapter 2 MicroRNAs in heart failure: from biomarker to target for therapy
Eur J Heart Fail. 2016 May;18(5):457-68
23
Chapter 3 Signature of circulating microRNAs in patients with acute heart failure
Eur J Heart Fail. 2016 Apr;18(4):414-23
53
Chapter 4 Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure
Int J Cardiol. 2016 Dec 1;224:231-239
77
Chapter 5 Associations between volume status and circulating microRNAs in acute heart failure
Eur J Heart Fail. 2017 Aug;19(8):1077-1078.
115
Chapter 6 Low circulating microRNA levels in heart failure patients are associated with atherosclerotic disease and cardiovascular-related rehospitalizations
Clin Res Cardiol. 2017 Aug;106(8):598-609.
123
Chapter 7 Rodent heart failure models do not reflect the human circulating microRNA signature in heart failure
Plos One. 2017 May 5;12(5):e0177242
153
Chapter 8 General discussion and future perspectives 185 Appendices Nederlandse samenvatting 209
Dankwoord 221
About the author 227
