Hyperlipidemia, inflammation and atherosclerosis : roles of
apolipoprotein C1 and cholesteryl ester transfer protein
Westerterp, M.
Citation
Westerterp, M. (2007, June 12). Hyperlipidemia, inflammation and atherosclerosis : roles of
apolipoprotein C1 and cholesteryl ester transfer protein. Retrieved from
https://hdl.handle.net/1887/12043
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/12043
Note: To cite this publication please use the final published version (if applicable).
Hyperlipidemia, Inflammation and Atherosclerosis
roles of apolipoprotein CI and cholesteryl ester transfer protein
Hyperlipidemia, Inflammation and Atherosclerosis
roles of apolipoprotein CI and cholesteryl ester transfer protein
PROEFSCHRIFT ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. Mr. P. F. van der Heijden, volgens het besluit van het College voor Promoties
te verdedigen op dinsdag 12 juni klokke 16.15 uur
door
Marit Westerterp
geboren te Stirling (Schotland, UK) in 1979
Promotiecommissie
Promotor: Prof. Dr. Ir. L.M. Havekes
Co-Promotor: Dr. P.C.N. Rensen
Referent: Prof. Dr. T.J.C. van Berkel
Overige commissieleden: Prof. Dr. J.A. Romijn Prof. Dr. J.W.A. Smit
Dr. C. Maugeais (F. Hoffmann-la Roche Ltd, Basel, Zwitserland)
Dr. A.K. Groen (AMC, Amsterdam)
The research described in this thesis was performed at the Gaubius Laboratory, TNO-Quality of Life, Leiden, and the Leiden University Medical Center, Leiden, The Netherlands. The research was financially supported by Netherlands Organization of Scientific Research (NWO-VIDI 917.36.351).
The printing of this thesis was kindly supported by:
TNO-Quality of Life F. Hoffmann-la Roche Ltd.
Merck, Sharp&Dohme B.V.
Boehringer-Ingelheim B.V.
Pfizer B.V.
Hope Farms, Woerden
Financial support by the Netherlands Heart Foundation and the Netherlands Organization of Scientific Research for the publication of this thesis is grate- fully acknowledged.
ISBN 978-90-9021926-4
Cover: Leiden, het dichtslibben van het hart van de stad.
Cover design: M.R. de Vries & M. Westerterp
Printed by: Gildeprint B.V., Enschede, The Netherlands
© M. Westerterp, Leiden, The Netherlands
All rights reserved. No part of this publication may be reproduced or trans- mitted in any form or by any means without written permission from the author.
Table of contents
Chapter 1 9
General introduction
Chapter 2 47
Endogenous apoCI increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL
J Lipid Res 2006;47:1203-1211
Chapter 3 71
Apolipoprotein CI binds free fatty acids and reduces their intracellular esterification
J Lipid Res 2007, in press
Chapter 4 95
Apolipoprotein CI aggravates atherosclerosis development in apoE- knockout mice despite mediating cholesterol efflux from macrophages Atherosclerosis 2007, in press
Chapter 5 113
Apolipoprotein CI is crucially involved in lipopolysaccharide-induced atherosclerosis development in apoE-knockout mice
Submitted for publication
Chapter 6 133
Cholesteryl ester transfer protein decreases HDL and severely aggravates atherosclerosis in APOE*3-Leiden mice
Arterioscler Thromb Vasc Biol 2006;26:2552-2559
Chapter 7 157
General discussion and future perspectives
Summary 179
Samenvatting 185
Publications 193
Curriculum Vitae 197
