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University of Groningen

Angiogenesis in liver fibrosis

Adlia, Amirah

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2017

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Adlia, A. (2017). Angiogenesis in liver fibrosis. University of Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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Paranymphs : Gillian Dempsey Valentina Francia

Cover design : Heliana Lubis (helianalubis23@gmail.com) Layout : Amirah Adlia

Printing : Ipskamp Printing

The work presented on this thesis was partly funded by the Indonesian Directorate General of Higher Education (DIKTI). Printing of this thesis was financially supported by the University of Groningen, Faculty of Mathematics and Natural Sciences and the University Library.

© 2017, Amirah Adlia

ISBN (printed version) : 978-90-367-9519-7 ISBN (digital version) : 978-90-367-9518-0

All rights reserved. No part of this thesis may be reproduced or transmitted in any form by any means without permission of the author.

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Angiogenesis in Liver Fibrosis

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. E. Sterken

and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 20 February 2017 at 12.45 hours

by

Amirah Adlia born on 7 November 1987

in Palembang, Indonesia

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Supervisors Prof. G.M.M. Groothuis Prof. K. Poelstra Assessment Committee Prof. P. Olinga Prof. G. Molema

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For Aba, Mama, Habibi, Ellen, and Rafif

in love and gratitude

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CONTENTS

CHAPTER

1

CHAPTER

2

GENERAL INTRODUCTION

11-26

CELL SPECIFIC DELIVERY OF INTERFERON

ALPHA AND ITS ANTI-ANGIOGENIC ACTIVITY IN

HEPG2 CELLS

29-44

CHAPTER

3

CHAPTER

4

CELL SPECIFIC DELIVERY OF INTERFERON

ALPHA: IN VIVO EVALUATION

47-63

THE EFFECTS OF VEGF-A ON

FIBROSIS-ASSOCIATED ANGIOGENESIS

65-83

CHAPTER

5

CHAPTER

6

PRECISION-CUT LIVER SLICES AS AN

ALTERNATIVE MODEL TO STUDY

FIBROSIS-ASSOCUATED ANGIOGENESIS

85-105

SUMMARY, DISCUSSION, AND FUTURE

PERSPECTIVES

107-116

SAMENVATTING

119-124

ACKNOWLEDGEMENTs

127-133

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