University of Groningen
Novel Approaches for Developing Small Molecules to Target Histone Deacetylases
Cao, Fangyuan
DOI:
10.33612/diss.157448844
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Publisher's PDF, also known as Version of record
Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Cao, F. (2021). Novel Approaches for Developing Small Molecules to Target Histone Deacetylases. University of Groningen. https://doi.org/10.33612/diss.157448844
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Fangyuan Cao
2021
The research described in this thesis was carried out in the Department of Chemical and Pharmaceutical Biology (Groningen Research Institute of Pharmacy, University of Groningen, The Netherlands) and was financially supported by the China Scholarship Council.
The research work was carried out according to the requirement of the Graduate School of Science Faculty of Science and Engineering, University of Groningen, The Netherlands. Printing of this thesis was financially supported by the University Library and the Graduate School of Science, Faculty of Science and Engineering, University of Groningen, The Netherlands.
Cover design: Fangyuan Cao Printing: Ridderprint
Copyright © 2021 by Fangyuan Cao. All rights are reserved. No part of the thesis may be reproduced or transmitted in any form or by any means without the prior permission in writing of the author.
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PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Tuesday 23 February 2021 at 11.00 hours
by
Fangyuan Cao
born on 24 April 1990 in Changchun, China
Supervisors
Prof. F.J. Dekker Prof. G.J. Poelarends
Assessment Committee
Prof. A.S.S. Dömling Prof. P.H. h. Elsinga Prof. R.J. Pieters
CCoonntteennttss
CChhaapptteerr 11
Introduction and scope of the thesis
... 99
CChhaapptteerr 22
The process and strategy for developing selective histone deacetylase 3 Inhibitors
... 3311
CChhaapptteerr 33
Inhibitory selectivity among class I HDACs has a major impact on inflammatory gene expression in macrophages
... 5577
CChhaapptteerr 44
Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC)
... 9955
CChhaapptteerr 55
HDAC/MIF dual inhibitor inhibits NSCLC cell survival and proliferation by blocking the AKT pathway
... 113333
CChhaapptteerr 66
Summary and future perspectives
... 116611
AAppppeennddiicceess
Acknowledgement
... 117777
Publication
