Angiogenesis, proteases and angiogenic factors during the inception of pregnancy. Crucial contributors or trivial bystanders?
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(9) 5BCMF. First-trimester decidual mRNA expression of angiogenic factors (in ng/ μl). N3/"DPOUFOU NFBO4&. a "OHJPHFOJD'BDUPS. '(3 O. 'PMEJOEVDUJPO NFBO4&. b 1& O. '(3 O. 1& O. 7&('". 0.1 ± 0.0. 0.1 ± 0.0. 53 ± 46. 2±1. 1M('. 4.1 ± 1.8. 8.2 ± 3.1. 33 ± 21. 35 ± 24. ,%3. 0.7 ± 0.3. 1.7 ± 0.8. 26 ± 17. 13 ± 8. 'MU. 0.6 ± 0.2. 2.0 ± 1.3. 2±1. 3±2. "OH. 0.02 ± 0.0. 0.4 ± 0.4. 59 ± 34. 29 ± 21. "OH. 0.4 ± 0.2. 3.6 ± 2.0. 8±4. 5±3. 5*&. 0.9 ± 0.8. 19.6 ± 19.5. 37 ± 30. 68 ± 47. $IBQUFS. 'JSTUUSJNFTUFSEFDJEVBMN3/"FYQSFTTJPOXBTEFUFSNJOFECZ351$3BOEDPNQBSFECFUXFFOQSFHOBODJFT SFTVMUJOH JO '(3 PS 1& BOE UIFJS NBUDIFE DPOUSPMT 5IF °SFQFBUFE NFBTVSFT "/07"± XBT QFSGPSNFE UP BOBMZTFUIFEBUB B N3/"DPOUFOUXBTFYQSFTTFEJODZDMFUISFTIPME $U .FBO$UQFSHFOF("1%) 7&('" 1M(' ,%3 'MU "OH "OH BOE5*&$ZDMFUISFTIPMEXFSFDPOWFSUFEJOUPOHμM VTJOHBTUBOEBSEDVSWFPGUPUBM3/"7BMVFTXFSFDPSSFDUFEGPSN3/"JOQVUCZDBMDVMBUJOHUIFSBUJP OHμM UBSHFUHFOF. OHμM ("1%). BOEUIFTFWBMVFTBSFFYQSFTTFEBT®N3/"DPOUFOU¯JOUIFUBCMF C 'PMEJOEVDUJPOJODBTFTDPNQBSFEUPDPOUSPMTXBTDBMDVMBUFEBTUIFSBUJPOHμM DBTF OHμM DPOUSPMT . . %*4$644*0/ 5IFSFTVMUTTIPXFEUIBU¹STUUSJNFTUFSEFDJEVBMUJTTVFTPCUBJOFEGSPNDIPSJPOJDWJMMPVT TBNQMJOH FYQSFTTFE BMM FYBNJOFE BOHJPHFOJD GBDUPST N3/" MFWFMT PG 7&('" 1M(' ,%3 "OH "OHBOE5*&BQQFBSFEVOSFHVMBUFEJO'(3DBTFTDPNQBSFEUPNBUDIFE DPOUSPMT*OBEEJUJPO 1M(' "OHBOE5*&N3/"BQQFBSFEVOSFHVMBUFEJO1&DBTFT DPNQBSFEUPNBUDIFEDPOUSPMT)PXFWFS UIFMBSHFJOUFSJOEJWJEVBMWBSJBUJPOEJTBMMPXFE BOVOFRVJWPDBMDPODMVTJPO5IFEJGGFSFOUJBMFYQSFTTJPOPGBOHJPHFOJDGBDUPSTBQQFBSFE NPSFQSPNJOFOUJO'(3UIBOJO1& 5IFPSJHJOPGCPUI1&BOE'(3QSPCBCMZTUBSUTJOUIF¹STUUSJNFTUFS CFGPSFUIFPOTFUPG PWFSUEJTFBTFEVSJOHUIFMBTUUSJNFTUFS0VS¹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
(10) "OHJPHFOJDHSPXUIGBDUPSTJOQSFFDMBNQTJBBOEGPFUBMHSPXUISFTUSJDUJPO. EJG¹DVMU)PXFWFS UIFUPGPMEJOEVDUJPOPGHFOFTJOUIFTFTNBMMHSPVQTQSPNJTFT TJHOJ¹DBOUEJGGFSFODFTXIFOHSPVQTDPVMECFFYQBOEFE $VSSFOULOPXMFEHFSFHBSEJOH1&TVHHFTUTUIBUEFGFDUJWFWBTDVMBSSFNPEFMMJOHPGNBUFS OBMTQJSBMBSUFSJFTMFBETUPJNQBJSFEJOWBTJPOPGUSPQIPCMBTUT QMBDFOUBMJOTVG¹DJFODZBOE JTDIFNJB<-VUUVO $BSNFMJFU>5IFBGGFDUFEQMBDFOUBSFMFBTFTTPMVCMFBOUJBOHJPHFOJD GBDUPST MJLFTPMVCMF'MU T'MU BOEFOEPHMJO T&OH <.BZOBSEFUBM $MBSLFUBM C5KPBFUBM >5IFTFGBDUPSTBMUFSUIFBOHJPHFOJDCBMBODF NBJOMZCZOFVUSBMJT JOH7&('BOE1M(''VSUIFSNPSF UIFTFGBDUPSTBSFBCMFUPJOEVDFTZTUFNJDFOEPUIFMJBM EZTGVODUJPOBOE¹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¹STUUSJNFTUFSUJTTVFT *O UIF QSFTFOU TUVEZ N3/" MFWFMT PG 1M(' "OH BOE 5*& BQQFBSFE VOSFHVMBUFE JO GVUVSF1&QBUJFOUTDPNQBSFEUPDPOUSPMT7&('" ,%3 'MUBOE"OHTIPXFEDPN QBSBCMF FYQSFTTJPO MFWFMT /P QSFWJPVT SFQPSUT XFSF GPVOE UP SFGFSFODF UIFTF EBUB JO ¹STUUSJNFTUFS UJTTVFT 0OMZ ¹STUUSJNFTUFS TFSVN EBUB BSF BWBJMBCMF TIPXJOH SFEVDFE 1M('BOEJODSFBTFE7&('BOETºUJO¹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(12)
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