Cover Page
The following handle holds various files of this Leiden University dissertation:
http://hdl.handle.net/1887/70862
Author: Vries, M. de
Tumor biological characteristics of Vestibular Schwannoma © 2019 W.M. de Vries, The Netherlands
ISBN/EAN: 978-94-6380-263-5
Cover: Museo de las Ciencias Príncipe Felipe, València, photo by W.M. de Vries Design and Lay-out: wenz iD || www.wenzid.nl
Printed by: ProefschriftMaken || proefschriftmaken.nl
The research described in this thesis was carried out by the Department of Otolaryngology and Head & Neck surgery and the Department of Pathology of the Leiden University Medical Center and the Division of Pharmacology / Mouse Cancer Center of The Netherlands Cancer Institute, Amsterdam.
Copyright of the individual chapters is held by the publisher of the journal listed at the beginning of each respective chapter.
Tumor biological characteristics
of Vestibular Schwannoma
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 2 april 2019
klokke 16:15 uur door Maurits de Vries geboren te Utrecht
Promotiecommissie
Promotor Prof. Dr. P.C.W. Hogendoorn Co-promotor Dr. A.G.L. van der Mey Overige leden Prof. Dr. P.P. G. van Benthem
Prof. Dr. C.A.M. Marijnen
Table of Contents
CHAPTER 1
Introduction and outline of the thesis
9 CHAPTER 2Tumor biology of vestibular schwannoma: a review of experimental
data on the determinants of tumor genesis and growth characteristics
Otology & Neurotology (2015) 36: 1128-1136
21
CHAPTER 3
Intratumoral haemorrhage, vessel density and the inflammatory
reaction contribute to volume increase of sporadic vestibular
schwannomas
Virchows Arch (2012) 460:629–636
41
CHAPTER 4
Mutations affecting BRAF, EGFR, PIK3CA, and KRAS are not
associated with sporadic vestibular schwannomas
Virchows Archiv (2013) 462: 211-217
55
CHAPTER 5
Tumor-associated macrophages are related to volumetric growth
of vestibular schwannomas
Otology & Neurotology (2013) 34: 347-352
69
CHAPTER 6
BCRP expression in schwannoma, plexiform neurofibroma and MPNST
Oncotarget, (2017) 51: 88751-88759
83
CHAPTER 7
M-CSF and IL-34 expression as indicators for growth in Sporadic
Vestibular Schwannoma
Virchow Archiv (2018) ahead of print
97
CHAPTER 8
