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Cover Page

The handle http://hdl.handle.net/1887/68471 holds various files of this Leiden University

dissertation.

Author: Zhang, X.

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EXPANDING THE CAPABILITIES

OF ARTERIAL SPIN LABELING MRI

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Expanding the capabilities of Arterial Spin Labeling MRI Thesis, Leiden University Medical Center, The Netherlands ISBN: 978-94-92801-69-2

Printed by: Proefschrift-aio.nl

Copyright ©2018, Xingxing Zhang, Leiden, The Netherlands

The copyright of some of the articles that have been accepted for publication or that have been published, has been transferred to the respective journals The studies performed in this thesis were performed at the C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, the Netherlands.

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EXPANDING THE CAPABILITIES

OF ARTERIAL SPIN LABELING MRI

Proefschrift

ter verkrijging van de graad van doctor aan de Universiteit Leiden

op gezag van de Rector Magnificus prof.mr. C.J.J.M. Stolker volgens besluit van het college voor promoties

te verdedigen op januari 31, 2019 klokke 13:45

door Xingxing Zhang geboren te Jiangsu, China

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Promotor:

Prof. Dr. A. G. Webb Co-promotor:

Prof. Dr. Ir. M. J. P. van Osch Promotiecommissie: Prof. Dr. J. Hendrikse Dr. M. Smits

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Contents

1. General introduction and outline

2. Fast cerebral flow territory mapping using vessel encoded dynamic arterial spin labeling (VE-DASL)

3. Time efficient measurement of multi-phase arterial spin labeling MR-signal in white matter

4. Comparison of perfusion signal acquired by ASL prepared IVIM and conventional IVIM to unravel the origin of the IVIM-signal

5. Measure Labeling Efficiency for Pseudo-continuous Arterial Spin Labeling

6. In vivo blood T1 measurements at 1.5 T, 3 T, and 7 T

7. Discussion and Summary

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