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The handle http://hdl.handle.net/1887/43475 holds various files of this Leiden University dissertation
Author: Verdegaal, Suzan H.M.
Title: Diagnostics and treatment options in low-grade central chondrosarcomas
Issue Date: 2016-10-12
DIAGNOSTICS AND
TREATMENT OPTIONS IN LOW-GRADE CENTRAL CHONDROSARCOMAS
SUZAN H.M. VERDEGAAL
Diagnostics and treatment options in low-grade
central chondrosarcomas
Diagnostics and treatment options in low -grade central chondrosarcomas Suzan H .M. V erdegaal
Suzan H.M. Verdegaal
Voor Marijke, Lucas en Matt hijs
Suzan H.M. Verdegaal
Diagnostics and treatment options in low-grade central chondrosarcomas Thesis, Leiden University Medical Center, Leiden, The Netherlands
ISBN: 978-94-028-0177-4
Layout and cover design: Welmoed Schmidt Printing: Aanzet Grafische Vormgevers
Copyright © 2016 by S.H.M. Verdegaal. All rights reserved. No part of this book may be reproduced in any form without written permission of the author.
The publication of this thesis was financially supported by:
Nederlandse Orthopaedische Vereniging Anna Fonds te Leiden
Diagnostics and
treatment options in low-grade central chondrosarcomas
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden op gezag van
Rector Magnificus Prof. mr. C.J.J.M. Stolker volgens het besluit van het College voor Promoties te verdedigen op
12 oktober 2016 klokke 16.15 uur door
Suzanna Henrica Maria Verdegaal
geboren te Leiden in 1971
Promotoren: Prof. dr. A.H.M. Taminiau Prof. dr. P.C.W. Hogendoorn
Leden: Prof. dr. J.L. Bloem
Prof. dr. R.G. Forsyth, Vrije Universiteit Brussel, België Prof. dr. A.J. Gelderblom
Dr. P.C. Jutte, Universitair Medisch Centrum, Groningen
Table of content
Chapter 1
General introduction 9
Chapter 2
Incidence, predictive factors and prognosis of chondrosarcoma in patients with Ollier disease and Maffucci syndrome: an international multicenter
study of 161 patients 21
Chapter 3
The cytotoxic effect of phenol and ethanol on the chondrosarcoma-derived cell line OUMS-27, an in vitro experiment 43
Chapter 4
Phenol levels during intralesional curettage and local adjuvant treatment of benign and low-grade malignant bone tumours 57
Chapter 5
Low-grade chondrosarcoma of long bones treated with intralesional
curettage followed by application of phenol, ethanol and bone-grafting 71
Chapter 6
MR imaging of atypical cartilaginous tumour/grade I central chondro- sarcoma after curettage and phenol application; recommendations
for follow-up 89
Chapter 7
Summary, discussion and concluding remarks 105
Chapter 8
Nederlandse samenvatting 113
Chapter 9
List of publications 119
Chapter 10
Curriculum Vitae 125
