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Cover Page The handle http://hdl.handle.net/1887/136523

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Cover Page

The handle http://hdl.handle.net/1887/136523 holds various files of this Leiden University

dissertation.

Author: Formica, C.

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MOLECULAR MECHANISMS INVOLVED IN

RENAL INJURY-REPAIR

AND ADPKD PROGRESSION

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Molecular mechanisms involved in renal injury-repair and ADPKD progression Chiara Formica

Leiden University Medical Center, The Netherlands ISBN: 978-94-6380-882-8

Layout & cover design: Chiara Formica

Printing: ProefschriftMaken www.proefschriftmaken.nl

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MOLECULAR MECHANISMS INVOLVED IN

RENAL INJURY-REPAIR

AND ADPKD PROGRESSION

PROEFSCHRIFT

ter verkrijging van

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Table of contents

Chapter 1 General Introduction 7

Chapter 2 Four-Jointed knock-out delays renal failure in an ADPKD model

with kidney injury 41

Chapter 3 Reducing YAP expression in Pkd1 mutant mice does not improve

the cystic phenotype 71

Chapter 4 Meta-analysis of polycystic kidney disease expression profiles

defines strong involvment of injury repair processes 97 Chapter 5 Characterisation of Transcription Factor Profiles in Polycystic

Kidney Disease (PKD): identification and validation of STAT3 and RUNX1 in the injury/repair response and PKD progression

125

Chapter 6 Summarizing discussion 157

Appendix Appendices 171

Nederlandse samenvatting 173

Curriculum vitae 176

List of publications 177

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