Cover Page
The handle
http://hdl.handle.net/1887/74055
holds various files of this Leiden University
dissertation.
Author: Wilbrink, L.A.
Cluster headache: expansion of the clinical spectrum
Leopoldine Wilbrink
Cluster headache: expansion of the clinical spectrum PhD thesis, Leiden University, The Netherlands, 2019 ISBN: 978-94-6332-498-4
© Leopoldine Wilbrink, The Netherlands 2019 Cover design: Poldi Petri
Lay out: Ferdinand van Nispen, my-thesis.nl
Printed by: GVO drukkers & vormgevers, Ede, The Netherlands
No part of this thesis may be reproduced in any form, by print, photocopy, digital file, internet, or any other means without written permission of the copyright owner.
Cluster headache:
expansion of the clinical spectrum
Proefschrift
Ter verkrijging van de graad van Doctor aan de Universiteit Leiden
op gezag van Rector Magnificus Prof. Mr. C.J.J.M. Stolker, volgens besluit van het College voor Promoties
te verdedigen op woensdag 19 juni 2019 klokke 15:00 uur
door
Leopoldine Albertine Wilbrink Geboren te Kerkrade
Promotores: Prof. Dr. M.D. Ferrari Prof. Dr. F.J.P.M. Huygen
Copromotor: Dr. J. Haan
Leden promotiecommissie: Prof. Dr. M.J.H. Wermer Dr. G.M. Terwindt Prof. Dr. A. Dahan
Dr. P.J. Koehler (Afdeling Neurologie, Zuyderland Medisch Centrum, Heerlen) Prof. Dr. K. Paemeleire (Department of Neurology, Ghent University Hospital)
The research described in this thesis was supported by grants of the Netherlands Organization for Scientific Research (NWO) [VICI 918.56.602 to M.D.F., VIDI 91711319 to G.M.T.], European Community (EC) [FP7-EUROHEADPAIN- no. 602633], the Dutch Ministry of Health, Medtronic and FondsNutsOhra. They had no role in the design or conduct of any of the studies.
Financial support for publication of this thesis has been provided by the Nederlandse Hoofdpijn Vereniging, and was gratefully accepted.
Contents
Chapter 1 General introduction 9
Part 1 Cluster headache genetics 35
Chapter 2 Stepwise web-based questionnaires for diagnosing cluster headache: LUCA and QATCH
37
Part 2 Cluster headache: comorbidity and clinical features 57
Chapter 3 Cluster headache and depression 59
Chapter 4 Allodynia in cluster headache 77
Chapter 5 Cluster-tic Syndrome: A Cross-Sectional Study of Cluster Headache Patients
93
Chapter 6 Aura-related symptoms associated with cluster headache: outcomes of a LUCA substudy
107
Chapter 7 Cluster headache and epilepsy 119
Part 3 The ICON study 133
Chapter 8 Occipital nerve stimulation in medically intractable, chronic cluster headache: The ICON study, Rationale and protocol of a randomised trial
135
Chapter 9 General discussion 155
