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The following handle holds various files of this Leiden University dissertation:
http://hdl.handle.net/1887/74007
Author: Baake, V.
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Huntington’s Disease
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Financial support for the printing of this thesis was kindly provided by the Dutch Huntington Association.
PhD Thesis, Leiden University Medical Center, Leiden 2019 Design & lay-out: Ton, Wouter en Verena Baake
ISBN: 978-94-028-1471-2 Printed by: Ipskamp Printing © 2019 Verena Baake, Haarlem
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Huntington’s Disease
Cognition and Apathy
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, RSJH]DJYDQ5HFWRU0DJQL¿FXVSURIPU&--06WRONHU
volgens besluit van het College voor Promoties te verdedigen op woensdag 29 mei 2019
klokke 13:45 uur door Verena Baake
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Promotor:
Prof. Dr. R.A.C. Roos
Promotiecommissie:
Dr. D. Craufurd, the University of Manchester Prof. Dr. H.P.H. Kremer, Rijksuniversiteit Groningen Prof. Dr. R.C. van der Mast
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Table of contents
Chapter 1: Introduction ... 7
Chapter 2: Participants at the Leiden site of the REGISTRY study:a demographic approach ...15
Chapter 3: Cognitive decline in Huntington’s disease expansion gene carriers ...31
Chapter 4: ,QÀXHQFHRIPHGLFDWLRQXVHRQFRJQLWLYH performance in Huntington’s disease ...59
Chapter 5: Apathy and atrophy of subcortical brain structures in Huntington’s disease:a two-year follow-up study ...81
Chapter 6: Huntington’s disease gene expansion carriers are aware of their degree of apathy ...97
Chapter 7: Discussion and concluding remarks ... 109
Nederlandse Samenvatting ... 116
List of publications ... 120
Dankwoord ... 121
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