University of Groningen
Towards identification and targeting of Polycomb signaling pathways in leukemia
Maat, Henny
DOI:
10.33612/diss.101427699
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Publication date:
2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Maat, H. (2019). Towards identification and targeting of Polycomb signaling pathways in leukemia.
Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.101427699
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TOWARDS IDENTIFICATION AND TARGETING OF
POLYCOMB SIGNALING PATHWAYS IN LEUKEMIA
The research described in this thesis was conducted at the Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
This research has been funded by the European Research Council (ERC-2011-StG 281474-huLSCtargeting) and Dutch Cancer Foundation (RUG 2014-6832).
Printing of this thesis was financially supported by University of Groningen, UMCG Graduate School of Medical Sciences, Stichting ter bevordering van de Hematologie Groningen and Onderzoeksfonds Hematon Cover: Some things only appear if you pay attention
ISBN: 978-94-034-1879-7 (print) ISBN: 978-94-034-1878-0 (e-book)
Cover design: Studio 212 Fahrenheit, Groningen (www.212f.nl) Copyright © BLOCBIRDS.com
Lay-out design: Tine Verhoef-Maat en Henny Maat Printing: Ipskamp Printing BV, Enschede Copyright © 2019 by Henny Maat.
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means without written permission of the author.
TOWARDS IDENTIFICATION AND TARGETING OF
POLYCOMB SIGNALING PATHWAYS IN LEUKEMIA
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
maandag 25 november 2019 om 11.00 uur
door
Henny Maat
geboren op 12 december 1988
Promotores
Prof. dr. J.J. Schuringa
Prof. dr. E. Vellenga
Beoordelingscommissie
Prof. dr. M. Vermeulen
Prof. dr. M.A.T.M. van Vugt
Prof. dr. G. de Haan
Paranimfen
Tine Verhoef-Maat
Marjan Geugien
CHAPTER 1
CHAPTER 2
CHAPTER 3
CHAPTER 4
CHAPTER 5
CHAPTER 6
APPENDICES
GENERAL INTRODUCTION &
SCOPE OF THIS THESIS
NON-CANONICAL PRC1.1 TARGETS ACTIVE GENES INDEPENDENT
OF H3K27ME3 AND IS ESSENTIAL FOR LEUKEMOGENESIS
Cell Rep. 2016 Jan 12;14(2):332-46.
USP7 AS PART OF NON-CANONICAL PRC1.1 IS A DRUGGABLE
TARGET IN LEUKEMIA
Preprint bioRxiv 221093; https://doi.org/10.1101/221093
TRANSCRIPTIONAL CONTROL OF PRC1.1 TARGET GENES IN
LEUKEMIC CELLS: ACTIVELY DRIVING TRANSCRIPTION OR
MAINTAINING LOCI IN A ‘TRANSCRIPTION PERMISSIVE’ STATE?
In progress
USING A LENTIVIRAL TET-REGULATED miR-E shRNA DUAL COLOR
VECTOR TO EVALUATE GENE FUNCTION IN HUMAN LEUKEMIC
STEM CELLS IN VIVO
Preprint bioRxiv 695965; https://doi.org/10.1101/695965
