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The handle http://hdl.handle.net/1887/47897 holds various files of this Leiden University dissertation.

Author: He, M.

Title: Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission

Issue Date: 2017-04-13

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Systems Diagnosis of Chronic Diseases, Explored by Metabolomics and Ultra-weak

Photon Emission

Min He

何敏

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Min He

Systems Diagnosis of Chronic Diseases, Explored by Metabolomics and Ultra-weak Photon Emission Thesis, Leiden University, 2017

ISBN/EAN: 978-94-6299-560-4 Printed by: Ridderprint BV Cover designed by Min He Thesis layout by Min He

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Systems Diagnosis of Chronic Diseases, Explored by Metabolomics and Ultra-weak

Photon Emission

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnifcus prof.mr. C.J.J.M. Stolker,

volgens het besluit van het college voor promoties te verdedigen op donderdag 13 april 2017

klokke 10:00 uur

door

Min He 何敏

Geboren te Qiqihar, Heilongjiang Province, P. R. China In 1984

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Promotor

Prof.dr. Jan van der Greef Co-promotores

Dr. Eduard van Wijk, Dr. Mei Wang

Promotiecommissie Prof.dr. Hubertus Irth

Leiden University, The Netherlands Prof.dr. Meindert Danhof

Leiden University, The Netherlands Prof.dr Franco Musumeci

University of Catania, Italy Prof.dr. Dirkjan van Schaardenburg

University of Amsterdam’s Faculty of Medicine, The Netherlands Prof.dr. Rob Verpoorte

Leiden University, The Netherlands Prof.dr. Guido Haenen

Maastricht University, The Netherlands Prof.dr. Jacqueline Meulman

Leiden University, The Netherlands

This research described in this thesis was financially supported by the Chinese Scholarship Council (CSC) with “Chinese government graduate student overseas study program” as a PhD scholarship (File no. 20108220166).

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Table of contents

Chapter 1 General introduction and aim of the thesis 7 Chapter 2 Collagen induced arthritis in DBA-1J mice associates

with oxylipin changes in plasma 17

Chapter 3 Role of amino acids in rheumatoid arthritis studied by

metabolomics 49

Chapter 4 Spontaneous ultra-weak photon emission in correlation to inflammatory metabolism and oxidative stress in a

mouse model of collagen-induced arthritis 71 Chapter 5 A Chinese literature overview on ultra-weak photon

emission as promising technology for studying system-

based diagnostics 101

Chapter 6 Traditional Chinese medicine-based subtyping of early- stage type 2 diabetes using plasma metabolomics

combined with ultra-weak photon emission 123 Chapter 7 Summary, Conclusions, and Perspectives 153

Samenvatting 161

List of publications 167

Curriculum vitae 169

Acknowledgements 171

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