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Tumor markers in T1-T2 laryngeal squamous cell carcinoma: Considerations on a clinical and biological level

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University of Groningen

Tumor markers in T1-T2 laryngeal squamous cell carcinoma

Wachters, Jasper E.

DOI:

10.33612/diss.150824808

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Wachters, J. E. (2021). Tumor markers in T1-T2 laryngeal squamous cell carcinoma: Considerations on a clinical and biological level. University of Groningen. https://doi.org/10.33612/diss.150824808

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551014-L-sub02-st-Wachters 551014-L-sub02-st-Wachters 551014-L-sub02-st-Wachters 551014-L-sub02-st-Wachters Processed on: 12-11-2020 Processed on: 12-11-2020 Processed on: 12-11-2020

Processed on: 12-11-2020 PDF page: 1PDF page: 1PDF page: 1PDF page: 1

STELLINGEN

behorende bij het proefschrift

Tumor markers in T1-T2 laryngeal squamous cell carcinoma

Considerations on a clinical and biological level J.E. Wachters

1. Reporting negative results is detrimental for further tumor marker research (this thesis).

2. Studies that do not differentiate between supraglottic and glottic laryngeal squamous cell carcinomas will not be able to identify relevant predictive/ prognostic tumor markers for radioresponse (this thesis).

3. The negligible predictive value of endogenous markers of hypoxia in T1-T2 supraglottic laryngeal squamous cell carcinoma is emphasized by its expression pattern (this thesis).

4. Slow pharmacokinetic characteristics hamper the effectivity of hypoxia targeted PET-scans (this thesis).

5. Dual functions of a protein like FADD, potentially distort its value as a predictor of clinical outcome (this thesis).

6. The association between PTEN expression and local control in supraglottic laryngeal squamous cell carcinomas treated with radiotherapy only, supports a role for PTEN in DNA-repair rather than tumor suppression (this thesis).

7. Health care retrenchments are an indication of social and moral decay (Lancet 2013; 381: 1323–31).

8. Auteurs van medische handboeken zouden eerst een cilinderkoppakking moeten vervangen, gebruikmakend van een Haynes Manual voor zowel didactische als spirituele zingeving.

9. Ook de zetel der wijsheid is gemaakt door een meubelmaker (J. Stiekema, Meubelfabriek, 2017, private uitgave).

10. Bij tijd en wijle dient men meer te laden dan turf in Siddeburen en suikerbieten in Appelscha (afgeleid van C. Stip, Dieuwertje Diekema, 1945).

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