University of Groningen Tumor methylation markers and clinical outcome of primary oral squamous cell carcinomas Clausen, Martijn

University of Groningen

Tumor methylation markers and clinical outcome of primary oral squamous cell carcinomas

Clausen, Martijn

DOI:

10.33612/diss.113437849

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Clausen, M. (2020). Tumor methylation markers and clinical outcome of primary oral squamous cell carcinomas: exploring the OSCC Methylome. Rijksuniversiteit Groningen.

https://doi.org/10.33612/diss.113437849

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STELLINGEN

Tumor methylation markers and clinical outcome of

primary oral squamous cell carcinomas

door Martijn Clausen

- The methylation status of WISP1, RAB25 and S100A9 predict the risk for the presence of lymph node metastases in Oral Squamous Cell Carcinomas (this thesis).

- The WISP1, RAB25 and S100A9 proteins are involved in the regulation of the calcium metabolism, and can serve as targets for pathway-targeted therapy in Oral Squamous Cell Carcinomas (this thesis).

- DNA methylation status of Oral Squamous Cell Carcinoma specific biomarkers

enables the detection of local recurrences in salivary rinses (this thesis).

- Publicly available large datasets are essential for proper biomarker validation (this thesis).

- The application of CRISPR opens up a new era of direct therapeutic treatment of DNA methylation biomarkers (Zhan et al., 2019).

- Crowdsourcing the analyses of NGS data is the future (Rodriguez et al., 2016). - Bioinformaticians are the key to the next step in personalized medicine (Cirillo and

Valencia, 2019, Suwinski et al., 2019)

- In solving a problem of this sort, the grand thing is to be able to reason backwards – Sherlock Holmes in Sir Arthur Conan Doyle’s A Study in Scarlet

- “To steal data from one person is plagiarism. To steal from many is research.” – Dr. Escotera

- そしてその砂嵐が終わったとき、どうやって自分がそいつをくぐり抜けて生

きのびることができたのか、君はよく理解できないはずだ。。。。でもひとつだ けはっきりしていることがある。その嵐から出てきた君は、そこに足を踏み いれたときの君じゃないっていうことだ。そう、それが砂嵐というものの意 味なんだ。 Translation: “And once the storm is over, you won’t remember how you made it through, how you managed to survive... But one thing is certain. When you come out of the storm, you won’t be the same person who walked in. That’s what this storm’s all about.” ― Haruki Murakami in “Kafka on the shore”