• No results found

University of Groningen Tumor methylation markers and clinical outcome of primary oral squamous cell carcinomas Clausen, Martijn

N/A
N/A
Protected

Academic year: 2021

Share "University of Groningen Tumor methylation markers and clinical outcome of primary oral squamous cell carcinomas Clausen, Martijn"

Copied!
7
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

University of Groningen

Tumor methylation markers and clinical outcome of primary oral squamous cell carcinomas

Clausen, Martijn

DOI:

10.33612/diss.113437849

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Clausen, M. (2020). Tumor methylation markers and clinical outcome of primary oral squamous cell

carcinomas: exploring the OSCC Methylome. Rijksuniversiteit Groningen.

https://doi.org/10.33612/diss.113437849

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

(2)

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

Processed on: 16-1-2020 Processed on: 16-1-2020 Processed on: 16-1-2020

Processed on: 16-1-2020 PDF page: 1PDF page: 1PDF page: 1PDF page: 1

Tumor methylation markers and

clinical outcome of primary oral

squamous cell carcinomas

Exploring the OSCC Methylome

Proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. C. Wijmenga

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

woensdag 5 februari 2020 om 14:30 door

(3)

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

Processed on: 16-1-2020 Processed on: 16-1-2020 Processed on: 16-1-2020

Processed on: 16-1-2020 PDF page: 2PDF page: 2PDF page: 2PDF page: 2

The research presented in this thesis was performed at the Department of Pathology and the Department of Oral and Maxillofacial Surgery at the University Medical Center Groningen, the University of Groningen, Groningen, The Netherlands. Part of the research presented was financially supported by the CTMM Air Force consortium (http://www.ctmm.nl). Financial support for printing was provided by the University Library and the Graduate School of Medical Sciences. ©Copyright 2020, M.J.A.M. Clausen

All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, without written permission of the author or when appropriate, from the publishers of the publications.

Cover thesisexpert.nl Lay-out thesisexpert.nl Printing Gildeprint

ISBN: 978-94-034-2400-2 (printed version) ISBN: 978-94-034-2401-9 (digital version)

(4)

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

Processed on: 16-1-2020 Processed on: 16-1-2020 Processed on: 16-1-2020

Processed on: 16-1-2020 PDF page: 3PDF page: 3PDF page: 3PDF page: 3

Tumor methylation markers and

clinical outcome of primary oral

squamous cell carcinomas

Exploring the OSCC Methylome

Proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. C. Wijmenga

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

woensdag 5 februari 2020 om 14:30 door

Martijn Jacobus Antonius Maria Clausen

geboren op 10 maart 1986

te Steenwijk

(5)

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

Processed on: 16-1-2020 Processed on: 16-1-2020 Processed on: 16-1-2020

Processed on: 16-1-2020 PDF page: 4PDF page: 4PDF page: 4PDF page: 4

Promotores

Prof. dr. E. Schuuring Prof. dr. J.L.N. Roodenburg

Beoordelingscommissie

Prof. dr. H. Hollema

Prof. dr. M. van Engeland Prof. dr. A.J.W.P. Rosenberg

Paranimfen

Dr. G. Eising Dr. T. Haer

(6)

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

Processed on: 16-1-2020 Processed on: 16-1-2020 Processed on: 16-1-2020

Processed on: 16-1-2020 PDF page: 5PDF page: 5PDF page: 5PDF page: 5

TABLE OF CONTENTS

Chapter 1

General Introduction

8

Chapter 2

Identification of methylation markers for the prediction of nodal

metastasis in oral and oropharyngeal squamous cell carcinoma

28

Chapter 3

Identification and validation of WISP1 as an epigenetic regulator of

metastasis in oral squamous cell carcinoma

46

Chapter 4

RAB25 expression is epigenetically down-regulated in oral and

oropharyngeal squamous cell carcinoma with lymph node metastasis

70

Chapter 5

Epigenetic regulation of S100A9 expression is related to lymph node

metastasis and disease specific survival in patients with oral squamous

cell carcinoma

92

Chapter 6

DNA hypermethylation of KCNA5 and TIMP3 is associated with tumor

cells in saliva from patients with OSCC

116

Chapter 7

General discussion

138

References

150

English scientific summary

166

Nederlandse samenvatting

170

Dankwoord

176

List of publications

182

(7)

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

540123-L-bw-Clausen

Processed on: 16-1-2020 Processed on: 16-1-2020 Processed on: 16-1-2020

Referenties

GERELATEERDE DOCUMENTEN

The assessment of oral squamous cell carcinoma: A study on sentinel lymph node biopsy, lymphatic drainage patterns and prognostic markers in tumor and saliva.. University

Taken together, this current knowledge of maxillary OSCC (incidence, bilateral drainage, retropharyngeal drainage, impact on survival and the assessment of individual

De studies die de basis vormden voor de aanpassing van de TNM classificatie, bevatten echter geen patiënten die een conservatieve behandeling van de hals hebben gehad, terwijl

Jij gaf tijdens deze jaren veel vrijheid in het indelen en organiseren van het onderzoek, maar wanneer nodig stond je deur altijd open.. Bij voorkeur na 17 uur, want dan had jij

The assessment of oral squamous cell carcinoma: A study on sentinel lymph node biopsy, lymphatic drainage patterns and prognostic markers in tumor and saliva.. University

With this methylome of metastatic OSCC, we aim to identify epigenetic markers that are associated with lymph node metastases in OSCC using both statistical analyses as well

To assess if methylation of the two predictive markers MGMT and DAPK1 was associated with decreased expression, we performed immunohistochemistry on the available tumor tissue of

Based on the amount of mRNA down-regulation; statistical differences in methylation between pN0 and pN+ OSCC; positive and negative predictive value; RAB25 was selected as the most