University of Groningen
The assessment of oral squamous cell carcinoma
Boeve, Koos
DOI:
10.33612/diss.135865241
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Boeve, K. (2020). The assessment of oral squamous cell carcinoma: A study on sentinel lymph node biopsy, lymphatic drainage patterns and prognostic markers in tumor and saliva. University of Groningen. https://doi.org/10.33612/diss.135865241
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COLOPHON
Cover design: James Jardine | www.jamesjardine.nl Layout: James Jardine | www.jamesjardine.nl Print: Ridderprint | www.ridderprint.nl ISBN: 978-94-93108-13-4
The research presented in this thesis was performed and financed at the Department of Oral and Maxillofacial Surgery and the Department of Pathology and Medical Biology at the University Medical Center Groningen, the University of Groningen, Groningen, The Netherlands.
Copyright © 2020 by Jacobus Boeve. All rights reserved. Any unauthorized reprint or use of this material is prohibited. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without written permission of the author or, when appropriate, of the publishers of the publications.
The assessment of oral
squamous cell carcinoma
A study on sentinel lymph node biopsy, lymphatic drainage
patterns and prognostic markers in tumor and saliva
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 28 oktober 2020 om 16.15 uur
door
Jacobus Boeve
geboren op 10 november 1988 te Kampen
Promotores
Prof. dr. J.L.N. Roodenburg Prof. dr. E.M.D. Schuuring Dr. M.J.H. Witjes
Copromoter
Dr. B. van der Vegt
Beoordelingscommissie
Prof. dr. J. Pruim Prof. dr. L.E. Smeele Prof. dr. A.J.H. Suurmeijer
Paranimfen
A.J. Tuin, MSc Mr. G.J. Boeve
01
General introduction and scope of this thesis 902
Addition of tumor infiltration depth and extranodalextension improves the prognostic value of the pathological TNM classification for early stage oral squamous cell carcinoma
35
03
High sensitivity and negative predictive value ofsentinel lymph node biopsy in a retrospective early stage oral cavity cancer cohort in the Northern Netherlands
53
04
High rate of unexpected lymphatic drainage patternsand a high accuracy of the sentinel lymph node biopsy in oral cancer after previous neck treatment
71
05
Lymphatic drainage patterns of oral maxillary tumors:Approachable locations of sentinel lymph nodes mainly at the cervical neck level
87
06
Amplification and protein overexpression of cyclinD1: Predictor of occult nodal metastasis in early oral cancer
101
07
In T1N0 staged oral squamous cell carcinomas with a tumor infiltration depth below 4 mm cortactin expression is associated with lymph node status123
08
Detection of tumor cells in saliva from patientswith oral squamous cell carcinoma using DNA hypermethylation of KCNA5 and TIMP3
143
