University of Groningen
Host-pneumococcal interactions - from the lung to the brain
Seinen, Jolien
DOI:
10.33612/diss.126438736
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Seinen, J. (2020). Host-pneumococcal interactions - from the lung to the brain. University of Groningen. https://doi.org/10.33612/diss.126438736
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Host-pneumococcal interactions
- from the lung to the brain
The studies presented in this thesis were conducted at the Department of Medical Microbiology, University of Groningen and the Department of Critical Care, University Medical Center Groningen, the Netherlands and the Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Germany.
The work described in this thesis was financially supported by the Graduate School of Medical Sciences of the University of Groningen and the Deutsche Forschungsgemeinschaft Grant GRK 1870.
Printing of this thesis was financially supported by the Graduate School of Medical Sciences of the University of Groningen and the University of Groningen Library.
ISBN: 978-94-034-2760-7 (printed version) ISBN: 978-94-034-2761-4 (electronic version)
CT scan of the lungs was kindly provided by Ronald Dob and Willem Dieperink Cover and layout by: Douwe Oppewal, www.oppewal.nl
Printed by: Ipskamp Printing, Enschede Copyright © Jolien Seinen, 2020
Host-pneumococcal interactions
- from the lung to the brain
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga
and in accordance with
the decision by the College of Deans
and
to obtain the degree of PhD at the
University of Greifswald
on the authority of the
Rector Magnificus Prof. J.E. Weber
and in accordance with
the decision by the Dean Prof. G. Kerth.
Double PhD degree
This thesis will be defended in public on
Monday 8 June 2020 at 14.30 hours
by
Jolien Seinen
born on 7 January 1989
in Heerenveen
Supervisors
Prof. J.M. van Dijl
Prof. S. Hammerschmidt
Prof. A.M.G.A. de Smet
Co-supervisor
Dr. W. Dieperink
Assessment committee
Prof. M. Schmidt
Prof. P. Heeringa
Prof. D. Becher
Prof. P. F. Zipfel
Paranymphs
Dr. L. M. Palma Medina
Dr. F. Romero Pastrana
7
Table of contents
Chapter 1 General introduction and scope of this thesis 9
Chapter 2 Heterogeneous antimicrobial activity in broncho-alveolar 23 aspirates from mechanically ventilated Intensive Care Unit patients
Virulence 2019, 10: 879-891
Chapter 3 Sputum proteome signatures of mechanically ventilated 47 Intensive Care Unit patients distinguish samples with or
without antimicrobial activity Submitted
Chapter 4 Modular architecture and unique teichoic acid recognition features 77 of choline-binding protein L (CbpL) contributing to pneumococcal
pathogenesis
Scientific Reports 2016, 6: 38094
Chapter 5 How does Streptococcus pneumoniae invade the brain? 111 Trends in Microbiology 2016, 24: 307-315
Chapter 6 Summary and future perspectives 127
Chapter 7 Nederlandse samenvatting 135
Biography 143
List of publications 144
