University of Groningen
Host-pneumococcal interactions - from the lung to the brain Seinen, Jolien
DOI:
10.33612/diss.126438736
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Seinen, J. (2020). Host-pneumococcal interactions - from the lung to the brain. University of Groningen. https://doi.org/10.33612/diss.126438736
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Propositions accompanying the thesis
Host-pneumococcal interactions - from the lung to the brain
1. Antimicrobial activity of sputum varies in time and space (Chapter 2).
2. The sputum microbiome can produce many antimicrobial compounds, but it seems unlikely to contribute to major anti-pneumococcal activities (Chapter 2).
3. It is presently not clear why the antibiotic cefotaxime may not exert its antimicrobial activity in sputum (Chapter 2).
4. Sputum antimicrobial activity should be protective against ventilator-associated pneumonia, but this is not mirrored in patient outcome (Chapter 2).
5. The sputum proteome of mechanically ventilated patients presents three distinct signatures of unknown origin (Chapter 3).
6. It will be a Sisyphus Challenge to disentangle the roles of different antimicrobial peptides and immunoglobulins in sputa with respect to their inhibitory effects on different microbial species (Chapter 3).
7. Choline-binding proteins are surface-exposed proteins involved in host-pneumococcal interactions (Chapter 4).
8. Blocking endothelial receptors to prevent pneumococcal passage across the blood-brain barrier with small molecules or antibodies is an attractive approach to prevent the onset of pneumococcal meningitis, and it is worth investigating whether the same principle can be applied to prevent pneumococcal translocation from the lung to the bloodstream (Chapter 5).
9. De kracht zit hem in de herhaling, maar aan alle ellende komt een einde (en vice versa). 10. A lion attacks only one buffalo at a time (Ethiopian proverb).
11. Sputum is complex matter.
