University of Groningen Geriatric syndromes; prevalence, associated factors and outcomes Rausch, Christian

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University of Groningen

Geriatric syndromes; prevalence, associated factors and outcomes

Rausch, Christian

DOI:

10.33612/diss.145064339

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Publication date: 2020

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Rausch, C. (2020). Geriatric syndromes; prevalence, associated factors and outcomes. University of Groningen. https://doi.org/10.33612/diss.145064339

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64114 Christian Rausch.indd 216

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About the author

Christian Philipp Rausch was born on the 30th of November 1989 in Berlin, Germany. Aft er one year as an exchange student in Pennsylvania, USA, Christian returned to Berlin and concluded his secondary education at the John F.-Kennedy German-American Community School. He then moved to the Netherlands in 2010 to study Medicine at the University of Groningen. Early in his studies, Christian undertook small research projects on hibernation at the Department of Pharmacology. A three-month research project on cellular changes in hibernating arctic ground squirrels at the University of Fairbanks and Toolik Fieldstation in Alaska, USA, formed the basis for his bachelor thesis. In 2013, Christian obtained his Bachelor´s degree in medicine, and completed the Bachelor´s Honours Programme of the University of Groningen. A year later, Christian obtained a Master´s degree in global health aft er defending is thesis on opioid analgesics and road traffi c crashes among older people, at the Karolinska Institutet in Stockholm, Sweden. Motivated by his work with large registry-based datasets, Christian continued to work at the Karolinska Institutet and was later granted the MD/PhD programme fellowship at the University of Groningen. From 2015 to 2019, he alternated years of research with years of clinical clerkships. His clinical clerkships were placed in the Netherlands at University Medical Center Groningen, in Germany at the Pius Hospital Oldenburg, in the United Kingdom at the John Radcliff e Hospital - Oxford University Hospitals and in Sweden at the Centralsjukhuset i Karlstad. Most of his research activities were conducted at the Department of Health Sciences at the University of Groningen/University medical Center Groningen and the Department of Global Public Health at the Karolinska Institutet. In 2017, he joined the Department of Pharmacoepidemiology at the Carl von Ossietzky University of Oldenburg, Germany for a research project on inappropriate medication use and dementia. Christian graduated from his MD in November 2018. Currently, Christian Rausch is employed as physician at the Department of Emergency Care and Internal Medicine at the Akademiska Sjukhuset (Uppsala University Hospital). In the future, he hopes to combine clinical work and research with a focus for the older population segment in global health issues, pharmacoepidemiology and social medicine.

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List of publications

• Rausch C, Hoffmann F. Prescribing medications of questionable benefit prior

to death: a retrospective study on older nursing home residents with and without dementia in Germany.

European Journal of Clinical Pharmacology. 2020;76(6):877-885. doi:10.1007/

s00228-020-02859-3

• Rausch C, Liang Y, Bültmann U, S. E. de Rooij, K. Johnell, L. Laflamme, J.

Möller. Social position and geriatric syndromes among Swedish older people: a population-based study.

BMC Geriatrics. 2019;19(1):267. Published 2019 Oct 15.

doi:10.1186/s12877-019-1295-8

• Liang Y, Rausch C, Laflamme L, Möller J. Prevalence, trend and contributing factors of geriatric syndromes among older Swedes: results from the Stockholm County Council Public Health Surveys.

BMC Geriatrics. 2018;18(1):322. Published 2018 Dec 29.

doi:10.1186/s12877-018-1018-6

• Rausch C, Laflamme L, de Rooij SE, Bültmann U, Möller J. Injurious falls and

subsequent adverse drug events among elderly - a Swedish population-based matched case-control study.

BMC Geriatrics. 2017;17(1):202. Published 2017 Sep 4.

doi:10.1186/s12877-017-0594-1

• Rausch C, Laflamme L, Bültmann U, Möller J. Number of medications and

adverse drug events by unintentional poisoning among older adults in consideration of inappropriate drug use: a Swedish population-based matched case-control study.

European Journal of Clinical Pharmacology. 2017;73(6):743-749. doi:10.1007/

s00228-017-2220-8

• Monárrez-Espino J, Laflamme L, Rausch C, Elling B, Möller J. New opioid analgesic use and the risk of injurious single-vehicle crashes in drivers aged 50-80 years: A population-based matched case-control study.

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Acknowledgements

This work does not only mark the completion of a five-year research journey, it also celebrates and commemorates more than ten wonderful years at the University of Groningen. Through this time, I have had the honour to work, study, live and meet some of the most incredible people and I would like to express my wholehearted gratitude to everyone who has supported me throughout these years.

First of all, I would like to thank my promotor team: Prof. Ute Bültmann, Prof. Sophia de Rooij, Prof. Lucie Laflamme and Dr. Jette Möller. My PhD endeavour involved a lot of movement, and different locations. I am grateful that you had the patience to let me find my own way, even though it probably appeared to be all over the place at times. Thank you for your patience, optimism, guidance and support.

Dear Ute, I will never forget one of our first meetings. We were both headed for Amsterdam airport, you flying to Denmark and me flying to Sweden. We really had to meet as the deadline for the MD/PhD application was approaching and thus we held our meeting during the train ride. This meeting speaks for us in many ways. The two of us have a strong interest for Scandinavian countries, a passion for Groningen and we both seem (at least over the last years) to be always on the move. Interestingly enough we could have communicated to another in our mother tongue, but seemed shy away from that as talking in English always appeared to be the more comfortable choice. Throughout the years, I have not left a single meeting with you unmotivated. Your constant optimism, kindness and support helped me throughout every phase of this PhD. I am grateful for all your time and advise. I also very much appreciate that you always supported my extra endeavours, which were not always fully related to my research projects. Danke, Tack, Bedankt and Thanks. Dear Sophia, a few months after you started your position at the geriatrics department, I had a meeting with you. I was fascinated and inspired by your passion and innovative thinking in the field of geriatrics and outside. During our first meeting you agreed right away to be part of this PhD project and I am grateful for all your insights and your trust. Your suggestions and advise always included new ideas and aspects, which always enriched our research projects. Thank you very much for your time, great support throughout these years and showing me the interesting areas in geriatric medicine. Dear Lucie, I have had

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the pleasure to work with you shortly after I came to Sweden in 2013. After my graduation, you instantly offered me an opportunity to stay in beautiful Stockholm and continue with research. You integrated me into your research group and took me on without a doubt. I am grateful you ensured that I continuously develop as a scientist, as well as clinician. Thank you for all the meetings, your teachings and continues support. Dear Jette, we too met shortly after I arrived in Sweden. Since then, you, Lucie and I had many meetings that were always productive and humorous at the same time. I am grateful for all the discussions the three of us had. Our debates and critical appraisals contributed a large part to this PhD. Thanks to you, I also developed a keen interest in epidemiology and statistics, and at the same time had a mentor to teach me. Thank you very much for your patience, openness, flexibility and your humour. Also, thanks for letting me sit with you and Yajun, because without the close proximity to the two of you I could never done two manuscripts with very new methodological approaches. Thanks for humouring me and my questions throughout all the years.

In addition, I would like to thank my co-authors Prof. Kristina Johnell, Dr. Sander van Zon and Dr. Yajun Liang. Dear Kristina, thank you for your help and inside. Your expertise on medications and adverse events and health risks among older people helped me substantially. I am thankful for the time and effort you put into these projects. Dear Sander, believe it or not, there was no one else in our department I spend more shared office time with than you. Working with you was great and I appreciate our collaboration on the latest projects. Your suggestions and critical thinking were to the point, and very much inspired me. Thank you for always meeting me, motivating me and exchanging ideas, particularly during the last two years. Dear Yajun, thank for your time and continuous enthusiasm. Our exchanges were filled with positivity. Whenever I tried a new statistical approach, particularly in the last manuscripts, you were there to help me. Thank you also for going down the jungle of geriatric syndromes with me, I would have gotten lost without you.

Also, I would like to thank the academic staff and colleagues at the Department

of Health Sciences, Community and Occupational Medicine of the University

of Groningen, University Medical Center Groningen. Thank you all for always welcoming your lost PhD student and colleague. Over the years, I have made it to all of your offices and I am grateful for the many conversations, thoughtful

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Acknowledgements

exchanges and welcoming attitude of you all. Thank you for always making me feel home.

In addition to that, I would like to thank the Department of Global Public

Health, the Injuries’ Social Aetiology and Consequences (ISAC) group and the

Epidemiology and Public Health Intervention Research (EPHIR) group at the Karolinska Institutet. Thank you for being a stable research home in Sweden over the last years and allowing me to participate whenever and wherever possible. Being part of the department and its research groups have given me endless food for thought.

I would also like to thank the assessment committee Prof. Barbara van Munster,

Prof. Tibor Hortobagyi and Prof. Johan Fastbom for reading and examining this

thesis, as well as taking their time to be part of this committee.

Furthermore, I would to express my gratitude to the great teachers, and mentors throughout the years at the University of Groningen, Dr. Rob Bakels, Prof. Jan

Kuks, Gerry Kremer and Dr. Michael Neumeyer. A special thanks to Prof. Rob Henning, who allowed and helped me to do my first research steps and then send

me off to Alaska to catch squirrels for my first academic thesis. Thank you! In this line of thought, I would also like to just acknowledge the amazing privilege I, as well as my friends had to study at the University of Groningen. The infrastructure of the University as well as the medical programme, and its MD/PhD programme ensured our development as global citizens. We had the ability to meet people from all over the world, and were given the chance to attend conferences, events and meetings anywhere on the globe. Thank you!

During the course of medical school and my PhD, I have spent a lot of time in Sweden, particularly in Stockholm and I would like to thank the people that made this time so special. Constance, we embarked on similar journeys with the global health masters, followed by a PhD. What better way to embark on a long journey like a PhD, than with a friend? Thank you for being there and always having an open ear. Mein Schweden-Bruder, Christian Luz. While you have become an integral part of the Groningen chapters, there are just too many memories that we share in Stockholm. I will never forget living with you in Årsta, when the

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roof ceiling fell apart, sending in our global health thesis, and the all the amazing evenings and conversations we had. I am glad to have had some PhD time with you in Groningen as well. Diego, amigo! My time at torsplan would not have been the same without you. Thank you for making sure I keep my spirit up. Lisa, it was great to have worked alongside with you at ISAC, and thank you for all your help! Of course, you Elena, Anna, Minhao, Vicky, Melody, Antonio, Mihretab, Jad,

Megan and Alicia need to be acknowledged as well. Thank you for uplifting times

in and out KI! My first clinical steps in Sweden were taken in Karlstad and they would not have been the same without your guidance Aydin Toksöz. A thanks also to my supervisors and colleagues at the internal medicine and emergency care department Akademiska sjukhuset, who helped me get up to speed in the clinical world, while I was finishing my PhD.

The MD/PhD programme also took me to Oldenburg in Germany, where I spent a year of my clinical clerkships and kept returning to on various occasions over the last years. Here, I have had the great pleasure to meet Jörg and Henrich. Thank you for your mentor- and friendship and all the amazing dinners. While in Oldenburg, I had the unique opportunity to embark on a new research project at the Department of Versorgungsforschung. Thank you, Prof. Falk Hoffmann for your support and help in and outside research.

This PhD, but also medical school, would not have been possible was it not for the great friends I have met in Groningen. Filipe, we became friends already at the selection day not only because we were the only loonies showing up in suits. I could write an entire PhD over all of our adventures. Thank you for being there during the good, the bad and the ugly. Thank you and Francesca also for hosting and humouring me on the occasions I came to Groningen over the last year. Thanks

Olaf, for all the amazing evenings in Groningen and being the inspirational person,

you are. Wills, Seb and Sven Groningen would not have been the same without all our trips and fun times. Sunniva, without you I would never have found my way to Scandinavia. Thank you for all the laughter! Robin, I will never forget our trip through California, making it to the international geriatrics conference. Thank you for being at all the important events and just being the great friend that you are. Matthias and Till, thank you for having your eyes wide open and encouraging our group of friends at any moment. Matthias, thank you for being the anchored person you are, running all those kilometres with me and always finding time

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to catch up. Till, there is much we connect over. Your endless drive has always inspired me, and I am grateful for our time in Oldenburg and Groningen and this surreal experience up north in Sweden. Xaver and Vera, thank you as well for being a home whenever I came to Groningen. Xaver, your authenticity and intelligence amaze me. Thank you for all your reflections and amazing evenings in the Koffer and your home. Benedikt, you were always there no matter what. Thank you for always having my back and being the motivator that you are. I would also like to thank my friends in Berlin with whom I grew up and who taught me many life lessons that ultimately helped me get through this PhD. Tim,

Marcus, Oliver, Christian, Marco thank you for all the amazing stories, thank you

for coming to Groningen and thank you for maintaining the friendship besides the distance. Tim, thank you for sharing so much with me and having time even when its just last minute out of nowhere. Marcus, thank you for your craziness and never-ending enthusiasm. Oliver, thank you for your positivity and drive.

Christian, thank you for your sarcasm, pragmatism and humour. Marco, thank

you for your uncut honesty and always having an open ear.

It goes almost without saying that this PhD, and the last years would not have been achievable without my family. Susann, Mom, ohne deine Unterstützung hätte ich diese Unterfangen wohl kaum bewältigt. Es kann nicht immer einfach gewesen meinem Fernweh zuzusprechen. Trotzdem hast du meinen Werdegang immer unterstützt, egal wohin dieser geführt hat. Dein Wertegefühl und deinen moralischen Kompass habe ich immer bewundert, und ich danke dir für all deine Ratschläge, Liebe und Hilfe. Danke das du immer da bist. Uwe, ohne deinen positiven Zuspruch hätte ich wahrscheinlich nie Medizin studiert und hätte all diese Erfahrungen niemals gemacht. Danke das du mich immer motiviert hast, an mich geglaubt hast und mich in jeder Weise unterstützt hast. Du und Mom seit von jedem Abenteuer, egal wo in der Welt, immer ein Teil gewesen. Danke auch an meine Großeltern Ingrid und Hans, die mir beigebracht haben aus allem das Beste zu machen. Danke auch an meine Onkels, Hans-Jürgen und Thomas, und deren Familien, für all die Unterstützung und Zusprüche in all den Jahren. Ein Dank auch an meine Großeltern Isa und Klaus, die mir Schweden in vielerlei Hinsicht nahegebracht haben, und meinem Weg interessiert gefolgt sind.

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An dieser Stelle möchte ich auch meinem Vater, Uli danken. Ich weiß du warst immer Stolz auf meine Entwicklung und hast die Realisierung vieler Pläne mit unterstützt. Danke für all die lustigen Momente und deinen Humor. Du wärest auch auf die erfolgreiche Beendigung dieses Kapitels stolz gewesen.

Dear Alexandra, since I moved to Sweden you were part of this long journey and all of its ups and downs. I am grateful to have had your support along with it. While the PhD meant I had more opportunities to be with you in Sweden, it also included a lot of distance. However, thanks to you, we created some beautiful memories (and visited many bakeries) wherever this journey went. Thank you for always looking out for me and making me smile. I am looking forward to the next adventures with you. A thank you also to Lynn and Lloyd, for their constant support and interest.

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Research Institute SHARE

This thesis is published within the Research Institute SHARE (Science in Healthy Ageing and healthcaRE) of the University Medical Center Groningen / University of Groningen.

Further information regarding the institute and its research can be obtained from our internet site: http://www.share.umcg.nl/

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