The following handle holds various files of this Leiden University dissertation:
http://hdl.handle.net/1887/72412
Author: Quinn, P.M.J.
Title: The Retinal Crumbs Complex: from animal models and retinal organoids to
therapy
The Retinal Crumbs Complex:
From Animal Models and Retinal Organoids to Therapy
The printing of this thesis was financially supported by Stichting Blindenhulp and the LUMC.
Copyright © Peter M. Quinn, 2019.
The Retinal Crumbs Complex:
From Animal Models and Retinal Organoids to Therapy
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op woensdag 15 mei 2019
klokke 13:45 uur
door
Peter Martin John Quinn
Prof. dr. C.J.F. Boon Dr. D.A. Baker Dr. L. van der Weerd
1.2 Aims and outline of this thesis 30
CHAPTER 2 Targeted ablation of CRB1 and CRB2 in retinal progenitor cells
mimics Leber congenital amaurosis
PLoS Genetics 2013; 9:e1003976
39
CHAPTER 3 CRB2 in immature photoreceptors determines the
superior-inferior symmetry of the developing retina to maintain retinal structure and function
Human Molecular Genetics 2018; 27:3137-3153
79
CHAPTER 4 Loss of CRB2 in immature Müller glial cells adjusts a retinitis
pigmentosa phenotype due to loss of CRB1 into a Leber congenital amaurosis phenotype
Human Molecular Genetics 2019; 28:105-123
119
CHAPTER 5 Gene therapy into photoreceptors and Müller glial cells
restores retinal structure and function in CRB1 retinitis pigmentosa mouse models
Human Molecular Genetics 2015; 24:3104-3118
161
CHAPTER 6 6.1 NTPDase2 as a surface marker to isolate flow
cytometrically a Müller glial cell enriched population from dissociated neural retinae
Journal of Neuroscience and Neurosurgery 2018; 1 (4): 117
6.2 Transplantation of sorted Müller glial cells into the mouse retina
Journal of Neuroscience and Neurosurgery 2018; 1 (5): 122
201
212
CHAPTER 7 Human iPS-derived retinas recapitulate the fetal CRB1 CRB2
complex and human photoreceptors and Müller glial cells are targets of AAV5
A modified version is published in Stem Cell Reports, 2019.
CHAPTER 8 Discussion
8.1 Retinogenesis of the Human Fetal Retina: An Apical polarity perspective
In preparation
8.2 Summary and Discussion
269
300
CHAPTER 9 9.1 Appendix I.
Production of iPS-Derived Human Retinal Organoids for Use in Transgene Expression Assays.
Methods in Molecular Biology 2018; 1715:261-273
