Modulation of VLDL triglyceride metabolism
Bijland, S.
Citation
Bijland, S. (2010, December 16). Modulation of VLDL triglyceride metabolism. Retrieved from https://hdl.handle.net/1887/16248
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Modulation of VLDL
triglyceride metabolism
Modulation of VLDL triglyceride metabolism
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdediging op donderdag 16 december 2010 klokke 13.45 uur
door
Silvia Bijland geboren te Zaanstad
in 1980
Promotiecommissie
Promotor: Prof. Dr. Ir. LM Havekes Copromotores: Dr. Ir. K Willems van Dijk
Dr. PCN Rensen
Overige leden: Prof. Dr. BK Groen (UMCG, Groningen) Prof. Dr. RR Frants
Prof. Dr. JA Romijn
Dr. HMG Princen (TNO, Leiden)
The research described in this thesis was financially supported by the Netherlands Organization for Health Care Research Medical Sciences (ZON-MW project nr.
948 000 04) and by grants from the Nutrigenomics Consortium/Top Institute Food and Nutrition (NGC/TIFN) and the Center of Medical Systems Biology (CMSB) established by The Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (NGI/NWO).
Studies presented in this thesis were performed at the department of Human Genetics and the department of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands and at the Gaubius Laboratory, TNO Quality of Life, Leiden, The Netherlands.
Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
Colophon
© S. Bijland, 2010. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, without prior permission in writing from the author.
ISBN: 978949109801 7
Cover design and Illustrations © S. Bijland Print by F&N Boekservices Eigenbeheer
Financial support for the publication of this thesis was kindly provided by
J.E. Juriaanse Stichting Novo Nordisk
Servier Nederland Farma B.V.
Table of contents
Chapter 1
General Introduction 9
Chapter 2
CETP does not affect triglyceride production or clearance in 25 ApoE*3-Leiden mice
Journal of Lipid Research 2010; 51: 97-102 Chapter 3
Fenofibrate increases VLDL-triglyceride production despite 39 reducing plasma triglyceride levels in ApoE*3-Leiden.CETP mice
The Journal of Biological Chemistry 2010;285(33):25168-75 Chapter 4
Rifampicin decreases plasma HDL and VLDL mainly by impairing 63 particle production in ApoE*3-Leiden.CETP mice
Manuscript in preparation Chapter 5
Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic 81 steatosis and hypolipidemia mainly by impairing lipoprotein
production in ApoE*3-Leiden.CETP mice Submitted
Chapter 6
Gene expression profiles distinguish fasting and high-fat diet 109 induced steatosis
Chapter 7
General discussion 127
Chapter 8
References 140
Summary 162
Nederlandse samenvatting voor niet-ingewijden 166
List of publications 170
Curriculum vitae 173
