Determinants of plasma levels of von Willebrand factor and coagulation factor VIII
Nossent, A.Y.
Citation
Nossent, A. Y. (2008, February 6). Determinants of plasma levels of von Willebrand factor and coagulation factor VIII. Retrieved from https://hdl.handle.net/1887/12592
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Determinants of Plasma levels of von
Willebrand Factor and Coagulation Factor VIII
Determinants of Plasma levels of von
Willebrand Factor and Coagulation Factor VIII
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden
op gezag van de Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op 6 februari 2008 klokke 13:45 uur
door
Anne Yaël Nossent
geboren te Hattem
in 1978
Promotiecommissie
Promotores: Prof. dr. R.M. Bertina
Prof. dr. F.R. Rosendaal
Co-promotor: Dr. H.C.J. Eikenboom
Referent: Prof. dr. M.M. Levi (Universiteit van Amsterdam)
Overige Leden: Prof. dr. J.P. Vandenbroucke Prof. dr. J.W. Jukema
Prof. dr. A.J. Rabelink
The research described in this thesis has been supported financially by grants from the Dutch Heart Foundation (NHS 2002T030), the Thrombosis Foundation Netherlands (TSN 2005-03) and the Leducq Foundation (Paris, France) for the development of Transatlantic Networks of Excellence in Cardiovascular Research and was performed at the Haemostasis and Thrombosis Research Center, Department of Haematology (now the Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis) of the Leiden University Medical Center in Leiden, the Netherlands.
Publication of this thesis was financially supported by the ‘Hettema-Heerema- Leen’.
Further financial support by the Netherlands Heart Foundation and the Thrombosis Foundation Netherlands for publication of this thesis is gratefully acknowledged.
Cover design: The cover of this thesis was designed by Albert Jan Nossent and features the newly renovated ‘Hezenberger Sluis’ in ‘Het Apeldoorns Kanaal’
near the city of Hattem in Gelderland, the Netherlands.
Lay-out: The lay-out of this thesis was performed by Dr. ing. Shirley Uitte de Willige.
© 2008 A.Y. Nossent ISBN:978-87-992288-0-5
Printed by Printpartners Ipskamp in Enschedé
Table of Contents
Chapter 1 Introduction 9
Chapter 2 Plasma Coagulation Factor Levels in Venous Thrombosis 19 Chapter 3 Von Willebrand factor and its Propeptide: The Influence
of Secretion and Clearance on Protein Levels and the Risk of Venous Thrombosis
43
Chapter 4a Haplotypes Encoding the Factor VIII 1241Glu Variation, Factor VIII Levels and the Risk of Venous Thrombosis
63
Chapter 4b Haplotypes Encoding the Factor VIII 1241Glu Variation and the Risk of Myocardial Infarction
83
Chapter 5 Beta 2 Adrenergic Receptor Polymorphisms: Association with Factor VIII and von Willebrand Factor Levels and the Risk of Venous Thrombosis
93
Chapter 6 Vasopressin 2 Receptor Gene Variations and the Regulation of Levels of von Willebrand Factor and Factor VIII and the Risk of Venous Thrombosis
101
Chapter 7 Plasma Levels of von Willebrand Factor Propeptide, von Willebrand Factor and Coagulation Factor VIII in Carriers and Patients with Nephrogenic Diabetes Insipidus
121
Chapter 8 Associations of Aquaporin 2 Gene Variations with Plasma Levels of von Willebrand Factor and Factor VIII and the Risk of Venous Thrombosis
143
Chapter 9 Associations of Blood Pressure and Antihypertensive Drugs with Plasma Levels of Coagulation Factor VIII
161
Chapter 10 Summary & Discussion 181
Chapter 11 Samenvatting 199
Nawoord 207
Curriculum Vitae 211
