Cover Page
The handle
http://hdl.handle.net/1887/73613
holds various files of this Leiden University
dissertation.
Author: Lentferink, Y.E.
The research described in this thesis was performed in the St. Antonius Hospital (Nieu-wegein/Utrecht, the Netherlands). The research was financially supported by a research grant by ZonMW (The Netherlands Organisation for Health Research and Development, project number 113201003) and by the St Antonius Hospital (Nieuwegein/Utrecht, The Netherlands).
Cover design: Yvette Lentferink and Erwin Timmerman of Optima Grafische Communicatie, Rotterdam Lay-out and printing: Optima Grafische Communicatie, Rotterdam ISBN: 978-94-6361-260-9
Copyright © 2019 by Yvette E. Lentferink
Comorbidities, complications and treatment of
childhood obesity
Proefschrift
Ter verkrijging van de graad van doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. Dr. C.J.J.M. Stolker, volgens besluit van het college voor promoties
te verdedigen op woensdag 22 mei 2019 klokke 10.00 uur
door
Yvette Elisabeth Lentferink Geboren te Blaricum, Nederland
Promotor
Prof. Dr. Catherijne A.J. Knibbe
Co-promotor
Dr. Marja M.J. van der Vorst (St. Antonius ziekenhuis)
Promotiecommissie
Prof. Dr. Hubertus Irth (voorzitter) Prof. Dr. Joke A. Bouwstra (secretaris) Prof. Dr. Hanno Pijl (LUMC)
Table of ConTenTs
Section 1: introduction and scope of the thesis
1. General introduction on comorbidities, complications and treatment of childhood obesity
9
Section 2: comorbidities in childhood obesity
2. Asthma medication in children with overweight/obesity: justified treatment?
27 3. Psychostimulants: influence on body mass index and height in a
pediatric population with Attention-Deficit/Hyperactivity Disorder?
43
Section 3: complications of childhood obesity
4. Predictors of insulin resistance in children versus adolescents with obesity
65 5. Increased arterial stiffness in adolescents with obesity 79 6. Skin autofluorescence in children with and without obesity 99 Section 4: treatment of childhood obesity
7. Efficacy of metformin treatment with respect to weight reduction in children and adults with obesity, a systematic review
119 8. Long term metformin treatment in adolescents with obesity and insulin
resistance, results of an open label extension study
147
Section 5: conclusions and perspectives
9. Conclusion and perspectives on comorbidities, complications and treatment of childhood obesity
173 10. Nederlandse samenvatting/Dutch summary 197
