Airway pathology in COPD : smoking cessation and
pharmacological treatment intervention. Results from the GLUCOLD study
Lapperre, T.S.
Citation
Lapperre, T. S. (2010, February 16). Airway pathology in COPD : smoking cessation and pharmacological treatment intervention. Results from the GLUCOLD study. Retrieved from https://hdl.handle.net/1887/14753
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Airway pathology in COPD:
smoking cessation and
pharmacological treatment intervention
Results from the GLUCOLD study
© T.S. Lapperre Cover design: L. Beljaars
Printed by: Pasmans Offsetdrukkerij BV, Den Haag The publication of this thesis was financially supported by:
Bontius Stichting, GlaxoSmithKline, Netherlands Asthma Foundation
Airway pathology in COPD:
smoking cessation and
pharmacological treatment intervention
Results from the GLUCOLD study
Proefschrift
ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Prof. Mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 16 februari 2010
klokke 16.15 uur
door
Thérèse Sophie Lapperre
geboren te Wilrijk (België) in 1974
Promotores
Prof. dr. P.S. Hiemstra Prof. dr. P.J. Sterk
Prof. dr. W. Timens (Universitair Medisch Centrum Groningen)
Overige leden
Prof. dr. T.W.J. Huizinga Prof. dr. J.A. Romijn
Prof. dr. G. Brusselle (Universitair Ziekenhuis Gent)
Prof. dr. J.H. van Krieken (Universitair Medisch Centrum St Radboud)
The studies in this thesis were financially supported by grants from the Netherlands Organiza- tion for Scientific Research (NWO), Dutch Asthma Foundation (NAF), GlaxoSmithKline (NL), Leiden University Medical Center (LUMC), University Medical Center Groningen (UMCG).
De arts (in tegenstelling tot de natuurvorser) houdt zich bezig met een enkel organisme, het menselijk wezen, waarbij hij ernaar streeft diens identiteit onder moeilijke omstandigheden intact te laten.
(Ivy McKenzie)
Contents
Chapter 1 General introduction and aims of the study
Chapter 2 Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease
Am J Respir Crit Care Med 2004;170(5):499-504
Chapter 3 Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and bronchoalveolar lavage in COPD
Chest 2007;131(1):53-9
Chapter 4 Relation between duration of smoking cessation and bronchial inflammation in COPD
Thorax 2006;61(2):115-21
Chapter 5 Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study
Respir Res 2007;8:85-93
Chapter 6 Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
Ann Intern Med 2009;151(8):517-527 Chapter 7 Conclusions and general discussion Chapter 8 Nederlandse samenvatting
Curriculum vitae Nawoord Bibliography
The GLUCOLD study group
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37
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162 163 165 167
