Citation
Westra, M. M. (2010, January 26). Crosstalk between apoptosis and inflammation in atherosclerosis. Retrieved from https://hdl.handle.net/1887/14616
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/14616
Note: To cite this publication please use the final published version (if applicable).
Marijke M. Westra
Crosstalk between Apoptosis and
Inflammation in Atherosclerosis
Crosstalk between Apoptosis and Inflammation in Atherosclerosis
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. Mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 26 januari 2010
klokke 16.15 uur
door
Marijke Marianne Westra geboren te Haskerland
in 1979
The studies presented in this thesis were supported by grant 912-02-037 from the Netherlands Organization for Scientific Research (NWO) and were performed at the Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.
The printing of this thesis was financially supported by:
Leiden/Amsterdam Center for Drug Research Universiteit Leiden
No part of this thesis may be reproduced or transmitted in any form or by any means, without written permission of the author.
Contents
Chapter 1 Introduction 9
Chapter 2 Apoptosis Associated Inflammation in Atherosclerotic Plaque Progression and Stability 31
Chapter 3 Gene Expression Profiling in Atherosclerotic Plaque Vulnerability Identifies Neuropeptide Y as a Marker of Plaque Vulnerability 53
Chapter 4 Leukocyte Bim Deficiency Induces Anti-Ox-LDL Auto- antibody Formation and T Cell and Immunoglobulin Accumulation in Atherosclerotic Lesions of LDLr-/- Mice 69
Chapter 5 Increased Foam Cell Formation and Atherosclerotic Plaque Apoptosis in LDLr-/- Mice Lacking Macrophage Mcl-1 87
Chapter 6 Compromised Focal Adhesion Kinase Function Does Not Alter Atherogenesis in ApoE-/- Mice despite Profound Effects on Lipid Metabolism and Inflammatory Status 107
Chapter 7 Summary and Discussion 123
Nederlandse Samenvatting 133
Abbreviations 139
Publications 142
Curriculum vitae 144
