Citation
Minkelen, R. van. (2008, February 18). Search for novel genetic risk factors for venous thrombosis : a dual approach. Retrieved from https://hdl.handle.net/1887/13501
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License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Search for novel genetic risk factors for venous thrombosis:
a dual approach
Search for novel genetic risk factors for venous thrombosis:
a dual approach
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnifi cus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 18 februari 2009 klokke 16:15 uur
door
Rick van Minkelen
geboren te Rheden
in 1979
The research described in this thesis was fi nancially supported by the Netherlands Organization for Scientifi c Research (NWO, grant 912-02-036) and was performed at the Hemostasis and Thrombosis Research Center (now the Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis), Department of Hematology of the Leiden University Medical Center, Leiden, the Netherlands.
Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
Additional support was kindly provided by AstraZeneca B.V., Bayer Healthcare B.V., BD Biosciences, Greiner Bio-One B.V., Instrumentation Laboratory B.V., Promega Benelux B.V., Roche Diagnostics Nederland B.V., Sanquin, Siemens Healthcare Diagnostics B.V. and Snijders Scientifi c B.V..
Cover: Chromosomen in wol met bouwstenen (Lego®) Coverdesign and lay-out: Peggy van Minkelen
© 2009 R. van Minkelen ISBN: 978-90-6464-316-3
Printed by Ponsen & Looijen B.V., Wageningen, the Nethelands
Table of contents
Chapter 1 General introduction
Chapter 2 Candidate genes
2.1 Haplotypes of IL1B, IL1RN, IL1R1 and IL1R2 and the risk of venous thrombosis
2.2 Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction
2.3 Sequence variants and haplotypes of the factor IX gene and the risk of venous thrombosis
2.4 The Marburg I polymorphism of factor seven-activating protease is not associated with venous thrombosis
Chapter 3 The Genetics In Familial Thrombosis (GIFT) Study
3.1 The Genetics In Familial Thrombosis (GIFT) study: sample collection and description of study population
3.2 Genome-wide scan in aff ected sibling pairs reveals two novel susceptibility regions for venous thromboembolism: the Genetics In Familial Thrombosis (GIFT) Study
3.3 Screening of eleven candidate genes, from the 7p21.3 and Xq25-q26.3 linkage regions, for association with venous thromboembolic risk:
results from The Genetics In Familial Thrombosis (GIFT) study
Chapter 4 General discussion and summary
Samenvatt ing Nawoord
Curriculum Vitae
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