Citation
Bot, M. (2009, January 15). Bioactive lipids as key regulators in atherosclerosis. Retrieved from https://hdl.handle.net/1887/13407
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Bioactive Lipids as Key Regulators
in Atherosclerosis
Bioactive Lipids as Key Regulators in Atherosclerosis
PROEFSCHRIFT ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 15 januari 2009
klokke 13.45 uur
door
Martine Bot geboren te Dordrecht
in 1979
The studies presented in this thesis were supported by grant TSN2004.001 from the Netherlands Thrombosis Foundation and were performed at the Division of Biophar- maceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.
Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
The printing of this thesis was financially supported by:
Leiden/Amsterdam Center for Drug Research Universiteit Leiden
J.E. Jurriaanse Stichting
Aan mijn ouders aan Eric
Bot, Martine
Bioactive Lipids as Key Regulators in Atherosclerosis Proefschrift Leiden.
Met literatuur opgave – Met samenvatting in het Nederlands
Chapter 1 Chapter 2
Chapter 3
Chapter 4 Chapter 5
Chapter 6
Chapter 7
Chapter 8
Chapter 9
Page 9 29
51
67
83
99
113
131
155 167 172 176 178
General Introduction
Lysophospholipids: Two-Faced Mediators in Atherosclerosis
Atherosclerotic Lesion Progression Changes Lysophosphatidic Acid Homeostasis to Favor Its Accumulation
Lipid Cartography of Mouse Atherosclerotic Plaques by Cluster-TOF-SIMS Imaging
Lysophosphatidic Acid Destabilizes Atherosclerotic Plaques in ApoE-/- Mice Partly by Activating Perivascular Mast Cells
LPA Administration Changes Atherosclerotic Plaque Phenotype in ApoE-/- Mice by Affecting Vascular Smooth Muscle Cell Content
FTY720, a Synthetic Sphingosine 1-Phosphate Analogue, Inhibits Development of Atherosclerosis in Low-Density Lipoprotein Receptor Deficient Mice Hematopoietic Sphingosine 1-Phosphate Lyase Deficiency Decreases Atherosclerotic Lesion Development in LDL Receptor Deficient Mice
General Discussion and Perspectives Table of Contents
Nederlandse Samenvatting List of Abbreviations List of Publications Curriculum Vitae
