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Stitzinger, M. (2007, February 1). Lipids, inflammation and atherosclerosis.
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Lipids, inflammation and atherosclerosis
Lipids, inflammation and atherosclerosis
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Dr.D.D.Breimer,
hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties te verdedigen op donderdag 1 februari 2007
klokke 15:00 uur
door
Miranda Stitzinger
geboren te Vlissingen op 10 mei 1979
The study described in this thesis was supported by a grant of the Netherlands Heart Foundation (NHF-2001B164) and was performed at the Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
The printing of this thesis was also financially supported by:
- LACDR
- Dr. Ir. van de Laar Stichting - J.E. Jurriaanse Stichting - NOTOX B.V.
The only difference between me and a madman is that I am not mad - Salvador Dali -
Aan mijn ouders voor Cornelis
Printing: PrintPartners Ipskamp, Enschede, The Netherlands ISBN-10: 90-74538-67-3
ISBN-13: 978-90-74538-67-1 Stitzinger, Miranda
Lipids, inflammation and atherosclerosis Proefschrift Leiden
Met literatuuropgave - Met samenvatting in het Nederlands
© 2007 Miranda Stitzinger
No part of this thesis may be reproduced or transmitted in any form or by any means, without written permission from the author.
TABLE OF CONTENTS
Chapter 1 General introduction 9
Chapter 2 Interleukin-9 in atherosclerosis: Therapeutic
application and endogenous function 37
Chapter 3 Interleukin-9 inhibits β-VLDL induced foam cell formation by reducing receptor expression in murine macrophages
53
Chapter 4 Lipid accumulation by β-VLDL alters LPS induced expression of lipid related genes in murine macrophages
69
Chapter 5 Scavenger receptor BI modulates LPS induced TNF-α production and forms a host defense mechanism against inflammation
85
Chapter 6 Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet
101
Chapter 7 Characterization of the cholesterol lowering effect of interleukin-10 by microarray gene expression analysis of mouse liver parenchymal cells
119
Chapter 8 Summary and perspectives 137
Chapter 9 Nederlandse samenvatting 145
List of abbreviations 151
List of publications 153
Curriculum vitae 155
Nawoord 157
