University of Groningen
MicroRNAs as regulators of lung homeostasis, abnormal repair and ageing
Ong, Jennie
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Publication date: 2019
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Ong, J. (2019). MicroRNAs as regulators of lung homeostasis, abnormal repair and ageing. Rijksuniversiteit Groningen.
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MicroRNAs as regulators of lung
homeostasis, abnormal repair and ageing
Jennie Ong
The studies presented in this thesis were financially supported by the Lung Foundation Netherlands (Longfonds; grant number: 3.2.12.044) and by the Australian National Health and Medical Research Council (NHMRC; grant number: APP1104704).
Printing of this thesis was financially supported by: The University of Groningen, Graduate school of Medical Sciences Groningen (GSMS) and the Lung Foundation Netherlands (Longfonds).
Cover design by Xian Ong Layout design by Jennie Ong Printed by Gildeprint
ISBN (Print): 978-94-034-1714-1 ISBN (Digital): 978-94-034-1713-4 © 2019, J. Ong
All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without prior permission of the author, or when appropriate, of the publishers of the publications.
MicroRNAs as regulators of lung
homeostasis, abnormal repair and ageing
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus, prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 24 juni 2019 om 9.00 uur
door
Jennie Ong
geboren op 12 november 1990 te Nijmegen
The studies presented in this thesis were financially supported by the Lung Foundation Netherlands (Longfonds; grant number: 3.2.12.044) and by the Australian National Health and Medical Research Council (NHMRC; grant number: APP1104704).
Printing of this thesis was financially supported by: The University of Groningen, Graduate school of Medical Sciences Groningen (GSMS) and the Lung Foundation Netherlands (Longfonds).
Cover design by Xian Ong Layout design by Jennie Ong Printed by Gildeprint
ISBN (Print): 978-94-034-1714-1 ISBN (Digital): 978-94-034-1713-4 © 2019, J. Ong
All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without prior permission of the author, or when appropriate, of the publishers of the publications.
MicroRNAs as regulators of lung
homeostasis, abnormal repair and ageing
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus, prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 24 juni 2019 om 9.00 uur
door
Jennie Ong
geboren op 12 november 1990 te Nijmegen
Promotores
Prof. dr. W. Timens
Prof. dr. J.H.M. van den Berg
Copromotores
Dr. C.A. Brandsma Dr. J.L. Kluiver
Beoordelingscommissie
Prof. dr. T. Maes
Prof. dr. H.A.M. Kerstjens Prof. dr. J.L. Hillebrands
Paranimfen
Hataitip Tasena Wierd Kooistra
Promotores
Prof. dr. W. Timens
Prof. dr. J.H.M. van den Berg
Copromotores
Dr. C.A. Brandsma Dr. J.L. Kluiver
Beoordelingscommissie
Prof. dr. T. Maes
Prof. dr. H.A.M. Kerstjens Prof. dr. J.L. Hillebrands
Paranimfen
Hataitip Tasena Wierd Kooistra
To my family
To my family
TABLE OF CONTENTS
Chapter 1
General introduction & scope of the thesis 11Chapter 2
Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts (PloS One. 2017;12(9): e0183815)25
Chapter 3
Marked TGF-β-regulated miRNA expression changes in both COPD and control lung fibroblasts (under review)57
Chapter 4
Decreased miR-335-5p expression in parenchymal lung fibroblasts of current smokers (work in progress)85
Chapter 5
Age-related gene and miRNA expression changes in airways of healthy individuals (Sci Rep. 2019;9:3765)109
Chapter 6
Summary, discussion and future perspectives 129Chapter 7
Nederlandse samenvatting voor niet-ingewijden &中文概述(Chinese summary) 149 List of publications Dankwoord (Acknowledgements) 163 165
TABLE OF CONTENTS
Chapter 1
General introduction & scope of the thesis 11Chapter 2
Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts (PloS One. 2017;12(9): e0183815)25
Chapter 3
Marked TGF-β-regulated miRNA expression changes in both COPD and control lung fibroblasts (under review)57
Chapter 4
Decreased miR-335-5p expression in parenchymal lung fibroblasts of current smokers (work in progress)85
Chapter 5
Age-related gene and miRNA expression changes in airways of healthy individuals (Sci Rep. 2019;9:3765)109
Chapter 6
Summary, discussion and future perspectives 129Chapter 7
Nederlandse samenvatting voor niet-ingewijden &中文概述(Chinese summary) 149 List of publications Dankwoord (Acknowledgements) 163 165
