The handle http://hdl.handle.net/1887/58768 holds various files of this Leiden University dissertation
Author: Helmerhorst, H.J.F.
Title: The effects of oxygen in critical illness
Issue Date: 2017-10-04
T H E E F F E C T S O F OX YG E N I N C R I T I C A L I L L N E S S
Hendrik J.F. Helmerhorst
ISBN: 978-94-6182-821-7
Copyright © 2017 H.J.F. Helmerhorst
No part of this thesis may be reproduced or transmitted in any form or by any means, without the prior permission of the author.
The research described in this thesis was supported by an unrestricted grant from the Netherlands Organization for Health Research and Development (ZonMw).
Printing of this thesis was financially supported by Getinge, Vygon, ChipSoft and the University of Leiden.
Hendrik J.F. Helmerhorst was supported by the European Society of Intensive Care Medicine – Young Investigator Award.
T H E E F F E C T S O F OX YG E N I N C R I T I C A L I L L N E S S
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op 4 oktober 2017
klokke 16:15
door
Hendrik Jeroen Frans Helmerhorst geboren te Amsterdam
in 1986
Copromotor: Dr. D.J. van Westerloo
Promotiecommissie: Prof. Dr. A. Dahan
Prof. Dr. N.F. de Keizer Universiteit van Amsterdam Prof. Dr. T. van der Poll Universiteit van Amsterdam Prof. Dr. R.A.E.M. Tollenaar
Dr. M.S. Arbous
Dr. D.C.J.J. Bergmans Universiteit Maastricht
TA B L E O F CO N T E N T S
Chapter 1 General introduction 7
PA RT I PAT H O P H YS I O LO G I C A L A N D P R E C L I N I C A L CO N C E P T S 1 5 Chapter 2 Bench-to-bedside review: the effects of hyperoxia during critical illness 17 Chapter 3 Hyperoxia provokes a time- and dose-dependent inflammatory response in 39
mechanically ventilated mice, irrespective of tidal volumes
PA RT I I C L I N I C A L E F F E C T S A N D A S S O C I AT E D O U TCO M E S 5 7 Chapter 4 Hemodynamic effects of short-term hyperoxia after coronary artery 59
bypass grafting
Chapter 5 Associations of arterial carbon dioxide and arterial oxygen concentrations with 75 hospital mortality after resuscitation from cardiac arrest
Chapter 6 Association between arterial hyperoxia and outcome in subsets of critical illness: 93 a systematic review, meta-analysis and meta-regression of cohort studies
Chapter 6a To the editor: Association between hyperoxia and mortality after cardiac arrest 115
Chapter 6b The authors reply 121
Chapter 7 Metrics of arterial hyperoxia and associated outcomes in critical care 127
PA RT I I I OX YG E N M A N AG E M E N T A N D P R E V E N T I V E S T R AT E G I E S 14 5 Chapter 8 Self-reported attitudes versus actual practice of oxygen therapy by 147
ICU physicians and nurses
Chapter 9 Effectiveness and clinical outcomes of a two-step implementation of 163 conservative oxygenation targets in critically ill patients: a before and after trial
Chapter 9a To the editor: Oxygen as an essential medicine: under- and over-treatment of 181 hypoxemia in low- and high-income nations
Chapter 9b The authors reply 187
Chapter 10 General discussion and summary 193
Appendix Nederlandse samenvatting 203
Curriculum vitae 207
Portfolio 208
List of publications 209
Dankwoord 211
