Cover Page
The handle http://hdl.handle.net/1887/18920 holds various files of this Leiden University dissertation.
Author: Diepen, Janna Alida van
Title: The role of inflammation in lipid metabolism Date: 2012-05-03
The role of inflammaTion in lipid meTabolism
Janna van diepen
The role of inflammaTion in lipid meTabolism
proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 3 mei 2012
klokke 16.15 uur door
Janna Alida van Diepen
geboren te Wageningen in 1983
promoTiecommissie
Promotor: Prof. Dr. L.M. Havekes Prof. Dr. J.A. Romijn Prof. Dr. P.C.N. Rensen Co-promotor: Dr. P.J. Voshol
Overige leden: Prof. Dr. M.H. Hofker (Rijksuniversiteit Groningen) Prof. Dr. S. Kersten (Wageningen Universiteit) Prof. Dr. C.J. Tack (Radboud Universiteit Nijmegen) Dr. R. Shiri-Sverdlov (Universiteit Maastricht)
The work described in this thesis was performed at the department of Endocrinology and Metabolic Diseases at the Leiden University Medical Center, Leiden,
The Netherlands.
The research described in this thesis was financially supported by the Netherlands Organization for Scientific Research (NWO 917.76.301) and the Dutch Diabetes Research Foundation (2005.01.003).
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged
ISBN: 978-94-6182-090-7
The printing of this thesis was financially supported by:
The Dutch Diabetes Research Foundation J.E. Jurriaanse Stichting
Novo Nordisk B.V.
Boehringer Ingelheim Greiner Bio-One
Layout & printing: Off Page, www.offpage.nl Copyright © 2012 by J. van Diepen, Leiden. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means without permission of the author and the publisher holding the copyright of the articles.
Table of conTenTs
Chapter 1 General Introduction 9
Chapter 2 Interplay between lipid metabolism and inflammation 17 – two targets in the treatment of atherosclerosis
Submitted
Chapter 3 Aspirin reduces hypertriglyceridemia by lowering 41 VLDL-triglyceride production in mice fed a high-fat diet
Am J Physiol Endocrinol Metab 2011; 306: E1099-107
Chapter 4 Hepatocyte-specific IKK-β activation enhances 59 VLDL-triglyceride production in APOE*3-Leiden mice
J Lipid Res 2011; 52: 942-50
Chapter 5 Hepatocyte-specific IKK-β expression aggravates 79 atherosclerosis development in APOE*3-Leiden mice
Atherosclerosis 2012; 220: 362-8
Chapter 6 Toll-like receptor 4 deficiency does not reduce 105 VLDL-triglyceride production in mice fed a high-fat diet
In preparation
Chapter 7 Inflammasome is a central player in the induction of 117 obesity and insulin resistance
Proc Natl Acad Sci U S A 2011; 108: 15324-9
Chapter 8 Caspase-1 deficiency reduces intestinal and hepatic 139 triglyceride-rich lipoprotein secretion
Submitted
Chapter 9 General Discussion and Future Perspectives 157
Summary 169
Samenvatting 175
Dankwoord 183
List of publications 187
Curriculum Vitae 191
