Cover Page
The handle http://hdl.handle.net/1887/19160 holds various files of this Leiden University dissertation.
Author: Amir, Avital
Title: Biology and clinical relevance of T-cell allo-HLA reactivity Date: 2012-06-28
Biology and clinical relevance of T-cell allo-Hla reacTiviTy
AvitAl Amir
Financial support
The work described in this thesis was financially supported by the Landsteiner Foundation for Blood Transfusion and the Dutch Cancer Society (KWF). Printing of this thesis was financially supported by the Dutch Cancer Society and the J.E. Jurriaanse Stichting.
coloFon
© A. Amir, 2012
Cover Design by Joshua Verheijen, De Huurlingen
Thesis Layout and Print by Optima Grafische Communicatie, Rotterdam
Biology and clinical relevance of t-cell allo-Hla reactivity
proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 28 juni 2012
klokke 13.45 uur door
avital amir geboren te Hadera (Israël)
in 1979
promotiecommissie
Promotor Prof. Dr. J.H.F. Falkenburg Co-promotor Dr. M.H.M. Heemskerk
Overige leden Prof. Dr. C.J.M. Melief Prof. Dr. F.H.J. Claas
Prof. Dr. R.A.W. van Lier (Sanquin)
contents
1. Introduction 7
2. Identification of a coordinated CD8 and CD4 T-cell response directed against mismatched HLA class I causing severe acute GVHD
29
3. Allo-HLA reactivity of virus-specific memory T-cells is common 47
4. Allo-HLA reactive T-cells inducing graft versus host disease are single
peptide specific 71
5. PRAME-specific allo-HLA-restricted T-cells with potent antitumor reactivity useful for therapeutic T-cell receptor gene transfer
93
6. Summary and general discussion 119
Nederlandse Samenvatting 135
Nawoord 141
Curriculum Vitae 143
List of publications 145
