Cover Page
The handle
http://hdl.handle.net/1887/139045
holds various files of this Leiden University
dissertation.
Author: Westhoff, S.
Title:
The ecology and evolution of microbial warfare in streptomyces
The Ecology and Evolution of
Microbial Warfare in
Streptomyces
The Ecology and Evolution of Microbial Warfare in Streptomyces
ISBN: 978-94-6416-349-0
Printing of this thesis was financially supported by the Netherlands Society of Medical Microbiology (NVMM) and the Royal Netherlands Society for Microbiology (KNVM). The studies in this thesis were financially supported by the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO).
Cover: S. Westhoff Lay-out: S. Westhoff
Printed by: Ridderprint B.V. |www.ridderprint.nl Copyright © 2020, S. Westhoff
All rights reserved. No part of this thesis may be reproduced, stored in retrieval systems, or transmitted in any form by any means, electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the author.
The Ecology and Evolution of
Microbial Warfare in
Streptomyces
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op woensdag 13 januari 2021
klokke 15:00
uur
door
Sanne Westhoff
geboren te Woerden, Nederland
in 1991
Promotores
Prof. dr. G.P. van Wezel Dr. D.E. Rozen
Leden promotiecommissie
Prof. dr. J.H. de Winde Prof. dr . A.H. Meijer Prof. dr. J.M. Raaijmakers
Prof. dr. K. Foster (Oxford University) Dr. P. Garbeva (NIOO-KNAW)
Table of Contents
Chapter 1 General introduction and outline of this thesis 7
Chapter 2 Distance dependent danger responses in bacteria 15
Chapter 3 The evolution of no-cost resistance at sub-MIC 33
concentrations of streptomycin in Streptomyces coelicolor
Chapter 4 Spatial structure increases the benefits of antibiotic 57
production in Streptomyces
Chapter 5 Competition sensing changes antibiotic production in 73
Streptomyces
Chapter 6 Transcriptomic profiling of Streptomyces coelicolor colonies 97
grown in close association with Kitasatospora sp. MBT66
Chapter 7 General discussion 117
Nederlandse samenvatting 127
References 137
Curriculum Vitae 156
