University of Groningen
Molecular imaging applications of antibody-based immunotherapeutics to understand cancer
drug distribution
Waaijer, Stijn
DOI:
10.33612/diss.144614649
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Waaijer, S. (2020). Molecular imaging applications of antibody-based immunotherapeutics to understand cancer drug distribution. University of Groningen. https://doi.org/10.33612/diss.144614649
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
MOLECULAR IMAGING APPLICATIONS OF
ANTIBODY-BASED IMMUNOTHERAPEUTICS
TO UNDERSTAND CANCER DRUG DISTRIBUTION
Waaijer, S.J.H.
Molecular imaging applications of antibody-based therapeutics to understand cancer drug distribution
Thesis, University of Groningen, Groningen, The Netherlands
©Stijn Waaijer, 2020
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronically, mechanically, by photo-copying, recording or otherwise, without the prior permission of the author
Cover Lisa Wessels - Stijn Waaijer
Layout Stijn Waaijer
Printed by Gildeprint
The research in this thesis is financially supported by European Research Council (ERC) grant OnQview, Dutch Cancer Society grant (RUG 2010-4739), Amgen and Chugai.
Printing of this thesis was supported by UMCG Graduate School of Medical Sciences, Stichting Werkgroep Interne Oncologie, and the University of Groningen
Molecular imaging applications of
antibody-based immunotherapeutics
to understand cancer drug distribution
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 30 november 2020 om 12.45 uur
door
Stijn Jan Hein Waaijer
geboren op 30 augustus 1991Promotores
Prof. dr. E.G.E. de Vries Dr. C.P. Schröder Dr. M.N. Lub-de Hooge
Beoordelingscommissie
Prof. dr. O.C. Boerman Prof. dr. J.G.W. Kosterink Prof. dr. J.A. Gietema
Paranimfen
Danique Giesen Luuk Pellen
CONTENTS
Chapter 1 General Introduction 9
Chapter 2 Molecular Imaging in Cancer Drug Development. 15 J Nucl Med. 2018;59(5):726-732
Chapter 3 Biodistribution and PET Imaging of Labeled Bispecific 33 T cell-Engaging Antibody Targeting EpCAM.
J Nucl Med. 2016;57(5):812-817
Chapter 4 Molecular Imaging of Radiolabeled Bispecific T-cell 51 Engager 89Zr-AMG211 Targeting CEA-Positive Tumors.
Clin Cancer Res. 2018;24(20):4988-4996
Chapter 5 89Zr-labeled Bispecific T-Cell Engager AMG 211 PET 73
shows AMG 211 Accumulation in CD3-Rich Tissues and Clear, Heterogeneous Tumor Uptake.
Clin Cancer Res. 2019;25(12):3517-3527
Chapter 6 Preclinical PET Imaging of Bispecific Antibody ERY974 97 Targeting CD3 and Glypican 3 Reveals that Tumor
Uptake Correlates to T Cell Infiltrate. J Immunother Cancer. 2020;8(1):e000548
Chapter 7 Tumor-Associated Macrophages in Breast Cancer: 123 Innocent Bystander or Important Player?
Cancer Treat Rev. 2018;70:178-189
Chapter 8 Radiolabeled Monoclonal Antibody Against Colony 151 Stimulating Factor 1 Receptor Specifically Distributes
to Spleen and Liver in Immunocompetent Mice Submitted
Chapter 9 Summary, General Discussion and Future Perspectives 169
Chapter 10 Nederlandse Samenvatting (Dutch Summary) 177
