University of Groningen
Preclinical evaluation and molecular imaging of HER family dynamics to guide cancer therapy
Kol, Klaas Jan-Derk
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Publication date: 2019
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Kol, K. J-D. (2019). Preclinical evaluation and molecular imaging of HER family dynamics to guide cancer therapy. Rijksuniversiteit Groningen.
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Preclinical evaluation and molecular imaging of
HER family dynamics to guide cancer therapy
Proefschrift
Ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 12 april 2017 om 12.45 uur
door
Arjan Kol
geboren op 2 maart 1987 te Duiven
Kol, K.J.
Preclinical evaluation and molecular imaging of HER family dynamics to guide cancer therapy Thesis, University of Groningen, Groningen, The Netherlands
ISBN: 978-94-034-1339-6
ISBN (electronic version): 978-94-034-1338-9 © K.J. Kol, 2018
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording, or otherwise, without prior written permission of the author.
Cover: Photo by Danique Giesen.
Printing by: Ipskamp Printing, Enschede, The Netherlands.
The research presented in this thesis was financially supported by European Research Council (ERC) advanced grant 293445, OnQview, a Roche Innovation Fund grant, a POINTING grant of the Dutch Cancer Society and a De Cock Stichting grant.
Printing of this thesis was supported by:
Stichting Werkgroep Interne Oncologie Graduate School of
Preclinical evaluation and
molecular imaging of HER family
dynamics to guide cancer therapy
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 30 januari 2019 om 12.45 uur
door
Klaas Jan-Derk Kol
geboren op 2 augustus 1988 te Ten Boer
Promotores: Prof. dr. S. de Jong Prof. dr. E.G.E. de Vries Copromotores:
Dr. A.G.T. Terwisscha van Scheltinga Beoordelingscommissie: Prof. dr. N.H. Hendrikse Prof. dr. H.J.M. Groen Prof. dr. F.A.E. Kruyt
Paranimfen: Martin Pool Thijs Stutvoet
CONTENTS
Chapter 1 General introduction and outline of thesis 9 Chapter 2 ADCC responses and blocking of EGFR-mediated signaling and cell growth by
combining the anti-EGFR antibodies imgatuzumab and cetuximab in NSCLC cells
Oncotarget. 2017;8:45432-45446
19
Chapter 3 Extracellular domain shedding influences specific tumor uptake and organ distribution of the EGFR PET tracer 89Zr-imgatuzumab
Oncotarget. 2016 18;7:68111-68121
49
Chapter 4 HER3, serious partner in crime: therapeutic approaches and potential biomarkers for effect of HER3-targeting
Pharmacol Ther. 2014;143:1-11
69
Chapter 5 89Zr-mAb3481 PET for HER3 tumor status assessment during lapatinib
treatment
MAbs. 2017;9:1370-1378
99
Chapter 6 MAPK pathway activity plays a key role in programmed death ligand-1 expression of EGFR wild-type lung adenocarcinoma cells
Submitted
121
Chapter 7 Summary, general discussion and future perspectives 149 Chapter 8 Nederlandse samenvatting (summary in Dutch) 163
