University of Groningen
Targeting breast cancer cells and their microenvironment
Nienhuis, Hilje Harmina
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Publication date: 2019
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Nienhuis, H. H. (2019). Targeting breast cancer cells and their microenvironment: Pre-clinical models and translational studies. Rijksuniversiteit Groningen.
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Targeting breast cancer cells
and their microenvironment
Pre-clinical models and
translational studies
Nienhuis, H.H.
Targeting breast cancer cells and their microenvironment; Pre-clinical models and translational studies
Thesis, University of Groningen, the Netherlands
The research presented in this thesis was financially supported by Dutch Cancer Society grant RUG 2010-4739, ERC advanced grant OnQview, 2010 Dutch Pink Ribbon Foundation grant Male Breast and Alpe d’HuZes grant RUG 2012-5565 (IMPACT).
The printing of this thesis was financially supported by the Stichting Werkgroep Interne Oncologie, the faculty of Medical Sciences, University of Groningen and Graduate School of Medical Sciences and is gratefully acknowledged.
Print: NetzoDruk, Groningen, the Netherlands Lay-out: Douwe Oppewal, www.oppewal.nl ISBN: 978-94-034-1251-1
Cover design: Hilde Nienhuis
© 2018, H.H. Nienhuis. All rights reserved. No part of this thesis may be reproduced, stored in retrieval systems, or transmitted in any form by any means, electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the author or, when appropriate, of the publisher of the published articles.
Targeting breast cancer cells and
their microenvironment
Pre-clinical models and translational studies
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 9 januari 2019 om 16.15 uur
door
Hilje Harmina Nienhuis
geboren op 11 januari 1987 te Groningen
4
Promotor
Prof. dr. E.G.E. de Vries
Copromotores
Dr. C.P. Schröder Dr. H. Timmer-Bosscha
Beoordelingscommissie
Prof. dr. E. van der Wall Prof. dr. H. Hollema Prof. dr. S. de Jong
5
Paranimfen
Wietske Rienstra Pieter Nienhuis
7
CONTENTS
Chapter 1 General introduction and outline of the thesis
9
Chapter 2 Targeting Breast Cancer Through its Microenvironment:
15
Current Status of Preclinical and Clinical Research in Finding
Relevant Targets
Pharmacology & Therapeutics, 2015
Chapter 3 Tumour-infiltrating Lymphocytes, PD-L1 and PD-1 Expression in a 53
Large Set of Primary Male Breast Cancer
Manuscript in preparation
Chapter 4
Human Stromal Cells are Required for an Anti-Breast Cancer
77
Effect of Zoledronic Acid
Oncotarget, 2015
Chapter 5 Near Infrared Fluorescent Antibody Imaging of Tumors
99
on Ex Ovo Chorioallantoic Membrane Assay
Revised and resubmitted
Chapter 6
18F-fluoroestradiol Tumor Uptake is Heterogeneous and
113
Influenced by Site of Metastasis in Breast Cancer Patients
Journal of Nuclear Medicine, 2018
Chapter 7 Summary and future perspectives
133
Chapter 8
Nederlandse samenvatting (Dutch summary)
144
Appendices Dankwoord (Acknowledgements)
148
Curriculum vitae
151
8
