Cover Page
The handle http://hdl.handle.net/1887/58921 holds various files of this Leiden University dissertation.
Author: Handgraaf, H.J.M.
Title: Intraoperative fluorescence imaging : clinical translation of targeted and non- targeted tracers
Issue Date: 2018-01-09
intraoperative fluorescence imaging
© H.J.M. Handgraaf 2017 cover photo
Annemarie Handgraaf design
Caroline de Lint (caro@delint.nl) isbn978-90-9030728-2
All rights reserved. No part of this thesis may be reproduced, distributed or transmit- ted in any form or by any means, without prior written permission of the author.
The research described in this thesis was financially supported by the Center for Translational Molecular Imaging, Dutch Cancer Society, European Research Council and National Institutes of Health.
The publication of this thesis was financially supported by the foundation Centre for Human Drug Research, Leiden, The Netherlands.
intra o perative flu o res c en c e ima g in g
Clinical translation of targeted and non-targeted tracers
proefschrift
Ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker, volgens besluit van het College voor Promoties te verdedigen op dinsdag 9 januari 2018 Klokke 16:15 uur
doorHenricus Johannes Marinus Handgraaf Geboren te Boxtel
In 1988
1 Outline of the thesis
part i. introduction to fluorescence imaging 2 Current and future intraoperative imaging strategies to
increase radical resection rates in pancreatic cancer surgery ...12
3 Real-time near-infrared fluorescence guided surgery in gynecologic oncology: a review of the current state of the art ...27
4 Identification of malignant tumors in the liver ...45
part ii. non-targeted tracers 5 Intraoperative near-infrared fluorescence imaging of multiple pan creatic neuroendocrine tumors: a case report ... 63
6 Intraoperative near-infrared fluorescence imaging of tumor border and sentinel lymph nodes in rectal cancer ...69
7 Long-term follow-up after near-infrared fluorescence-guided resection of colorectal liver metastases: a retrospective multicenter analysis ...81
8 Staging laparoscopy combined with ultrasonography and near-infrared fluorescence imaging to detect occult pancreatic metastases ...99
part iii. targeted tracers 9 Detecting tumor-positive resection margins after oralcancer surgery by spraying a fluorescent tracer activated by gamma- glutamyl trans pep tidase ...115
10 Real-time near-infrared fluorescence imaging using crgd-zw800-1 for multiple cancer types ...133
11 Real-time near-infrared fluorescence imaging of zw800-1 and crgd-zw800-1: a translational study in healthy volunteers ...153
part iv. summary and appendices 12 Summary and discussion ...171
13 Nederlandse samenvatting ...183
Curriculum vitae ...189
List of publications ...190
Dankwoord ...192 promotores
Prof. dr. C.J.H. van de Velde Prof. dr. J. Burggraaf co-promotor Dr. A.L. Vahrmeijer
leden promotiecommissie Prof. dr. L.F. de Geus-Oei Prof. dr. ir. B.P.F. Lelieveldt
Prof. dr. C.W.G.M. Löwik (Erasmus Medisch Centrum, Rotterdam) Dr. K. Bosscha (Jeroen Bosch Ziekenhuis, ’s-Hertogenbosch)
