Self-Replication out-of-Equilibrium
Yang, Shuo
DOI:
10.33612/diss.171627402
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Publication date:
2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Yang, S. (2021). Self-Replication out-of-Equilibrium. University of Groningen.
https://doi.org/10.33612/diss.171627402
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Self-Replication Out-of-Equilibrium
PhD thesis
University of Groningen
The research described in thesis was performed at Stratingh Institute for Chemistry, University of Groningen, the Netherlands. This work was financially supported by Chinese Scholarship Council (CSC), University of Groningen, the Netherlands Organization for Science Research (NWO) and European Research Council (ERC).
Cover design by Shuo Yang.
Self-Replication Out-of-Equilibrium
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Friday 28 May 2021 at 16.15 hours
by Shuo Yang
born on 14 April 1987 in Guangdong, China
Prof. dr. N.H. Katsonis Prof. dr. A. Walther Prof. dr. U. Lüning
Dedicated to my beloved wife Jingyi Huang
1.2 Supramolecular systems chemistry 2
1.2.1 Molecular motion 3
1.2.2 Complex compartmentalised networks 4
1.2.3 Oscillating systems 5
1.2.4 Reaction and diffusion 7
1.2.5 Dissipative self-assembly 7
1.3 Darwinian evolution in chemical systems 9
1.3.1 Replication 10
1.3.1.1 Self-replicating systems 10
1.3.1.2 DCC and our group’s replicating system 12
1.3.2 Mutation 14
1.3.3 Selection and dynamic kinetic stability 15
1.4 Origins of homochirality 16
1.5 Aims and outline of the thesis 18
1.6 References 20
2. Emergence of Competing Self-Replicators in Dynamic Molecular Networks
2.1 Introduction 24
2.2 Results and Discussion 25
2.3 Conclusions 30
2.4 Materials and methods 31
2.5 Supporting information 33
2.6 References 40
3. Kinetics of the Redox and Exchange Reactions of Thiol-Disulfide Chemistry
3.2 Results and discussion 43
3.3 Conclusion 49
3.4 Materials and methods 50
3.5 Supporting information 53
3.6 References 58
4. Chemical Fueling Enables Molecular Complexification of Assembly-Driven Self-Replicators
4.1 Introduction 62
4.2 Results and discussion 63
4.3 Conclusions 70
4.4 Materials and methods 71
4.5 Supporting information 76
4.5 References 91
5. A Self-Replicator with Chiral Selection
5.1 Introduction 96
5.2 Results and Discussion 97
5.3 Conclusion 102
5.4 Materials and methods 103
5.5 Supporting information 106
5.6 References 113
6. Overview and Perspectives
6.1 Research overview 116
6.2 Perspectives 116
Summary 120
Samenvatting 124
