Cover Page The handle

Cover Page

The handle http://hdl.handle.net/1887/19745 holds various files of this Leiden University dissertation.

Author: Faaij, Claudia Margaretha Johanna Maria

Title: Cellular trafficking in haematological and immunological disorders

Issue Date: 2012-09-05

Cellular Trafficking in Haematological and Immunological Disorders

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit van Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,

volgens besluit van het College voor Promoties te verdedigen op Woensdag 5 September 2012

klokke 10:00 uur

door

Claudia Margaretha Johanna Maria Faaij

geboren te ‘s Gravenhage

in 1979

Promotiecommissie

Promotor: Prof. Dr. R.M. Egeler Co-Promotores: Dr. M.J.D. van Tol

Dr. A.G.S. van Halteren

Overige leden: Prof. Dr. R.E. Mebius (VUMC, Amsterdam) Prof. Dr. G.J.L. Kaspers (VUMC, Amsterdam) Prof. Dr. J.H. Veelken

© 2012 Claudia Faaij, Voorburg, the Netherlands ISBN: 978-90-9026846-0

The research described in this thesis was performed in the Laboratory of Immunology, Department of Paediatrics, Leiden University Medical Centre (LUMC), Leiden, the Netherlands, and was financially supported by the LUMC and the Dutch Cancer Society (KWF) project grant: UL 2005-3657.

Financial support for the publication of this thesis was kindly provided by the Dutch Cancer Society (KWF), Astellas Pharma B.V. and BD Biosciences.

Cover picture: Traffick in the centre of Rotterdam. Made by Shirley Butter (www.butterleyphotography.

com).

Illustrations made by: Nathalie Bax (www.designbynathalie.nl)

Printed by: Drukkerij Rotterdam

Voor mijn ouders,

Voor Guido,

Voor Bente.

Contents

Chapter 1 7

General Introduction

Chapter 2 29

Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: differential roles for CCR2, CCR5, CXCR4 and CXCR7 Pediatric Blood & Cancer 2010 Aug;55(2):344-8.

Chapter 3 41

Decrease of skin infiltrating and circulating CCR10

T cells coincides with clinical improvement after topical tacrolimus in Omenn syndrome

Journal of Investigative Dermatology 2010 Jan;130(1):308-11

Chapter 4 53

A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4

T cells to skin in human graft-versus-host disease

British Journal of Haematology 2006 Jun;133(5):538-49

Chapter 5 75

In situ detection of HY-specific T cells in acute graft-versus-host disease- affected male skin after gender mismatched stem cell transplantation

Biology of Blood and Marrow Transplantation 2011 Nov 4.

Chapter 6 91

Fasciitis in chronic GvHD; Cross talk between host dermal macrophages and donor T cells

In preparation

Chapter 7 109

Summary and General Discussion

Nederlandse samenvatting 127

Curriculum Vitae 131

Publications 133