technology to neuromuscular disorders
Sterrenburg, P.J.E.
Citation
Sterrenburg, P. J. E. (2007, January 18). Application of microarray-based gene expression technology to neuromuscular disorders. Retrieved from https://hdl.handle.net/1887/8914
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License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Application of microarray-based
gene expression technology to
neuromuscular disorders
Ellen Sterrenburg
Application of microarray-based
gene expression technology to
neuromuscular disorders
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnifi cus Dr. D.D. Breimer,
hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties te verdedigen op donderdag 18 januari 2007
klokke 15:00 uur
door
Petronella Johanna Elisabeth Sterrenburg geboren te Eindhoven in 1977
Promotores Prof. Dr. G.J.B. van Ommen Prof. Dr. Ir. S.M. van der Maarel Co-pomotor Dr. J.T. den Dunnen
Referent Prof. Dr. A.F.M. Moorman (AMC, Amsterdam)
Overige leden Prof. Dr. B.G.M. van Engelen (UMC St. Radboud, Nijmegen) Dr. M. Antoniou (King’s College, London)
The research described in this thesis was performed in the Department of Human Genetics, Leiden University Medical Center, The Netherlands and was supported by grants from NWO and from the European Commission (TRI-EX QLG2-CT-2001-01673).
Cover: Myotubes stained for diff erent myogenic markers
-Do not wait for a reason to be happy - Mason Cooley
ISBN-10: 90-9021351-1 ISBN-13: 978-90-9021351-4 Sterrenburg, P.J.E.
Application of microarray-based gene expression technology to neuromuscular disorders. Thesis, Leiden University Medical Center
January 18, 2007
© 2007 Ellen Sterrenburg
No part of this thesis may be reproduced or transmitted in any form or by any means, without the written permission of the copyright owner
Contents
Chapter 1 Introduction 9
Chapter 2 A common reference in cDNA microarrays 41
Nucleic Acids Research, 2002, 30(21): e116 Chapter 3 Large-scale gene expression analysis of human skeletal 51
myoblast diff erentiation Neuromuscular disorders, 2004, 14(8-9): 507 Chapter 4 Gene expression profl iling highlights defective myogenesis 67
in DMD patients and a possible role for bone morphogenetic protein 4 Neurobiology of Disease, 2006, 23(1): 228 Chapter 5 Cellular model for oculopharyngeal muscular dystrophy 79
reveals an extracellular matrix defect Submitted for publication Chapter 6 Discussion 101
Summary 117
Samenvatting 119
List of publications 121
Curriculum vitae 123
Appendix 125
