PAMAM dendrimers with dual-conjugated vancomycin and Ag-nanoparticles do not induce bacterial resistance and kill vancomycin-resistant Staphylococci
15
0
0
Hele tekst
(2) 0123ÿ5678329 63 63ÿ
(3) ÿ
(4) ÿ ÿ. ÿÿ ÿ ÿ !"ÿ. 0123ÿ5678329 63 63ÿ. #$" ÿ%&' ()ÿ***+ "+&, , ÿ. -. ÿ 9/021ÿ3 261 9ÿ. 20303ÿ49/4 689 5ÿ6621ÿ4.3 717/8.03294ÿ93/178:16/ÿ3/4ÿ 007/3/7;3 261 95ÿ47ÿ/72ÿ6/4.19ÿ<3129 63 ÿ 956523/19ÿ3/4ÿ=6 ÿ 93/178:16/7 956523/2ÿ>?@ABCDEFEFFGÿ. H.689 6ÿI63/0ÿ3ÿJÿ<3JÿÿÿJÿUKU646ÿL6.ÿ3ÿJÿ<JÿÿM63/ 7/0<ÿÿN.ÿ3ÿJÿ<JÿÿO9/P96ÿQ.ÿ3ÿJÿ<JÿÿN686/ÿO9/ÿ1JÿÿR9//:ÿSTÿ93/ÿ49 ÿ < J ÿ U ÿ 396ÿ JÿI63/ÿL6.ÿ JÿR9/=ÿITÿ5.55119 ÿ. 3ÿ VWX?G?Y?ZÿE[ÿ\YWF?GEW@Dÿ]@WEÿ^ÿ>E[?ÿ_@?Z`G@DXÿa\b]>c_deÿfG@WgXYÿhZCÿi@jE`@?E`Cÿ[E`ÿk@`jEWlm@XZnÿ\YWF?GEW@Dÿ_@?Z`G@DXÿ^ÿoZpGFZXeÿ>EEFBEqÿbWGpZ`XG?Ceÿ. rssÿtZWu@Gÿtneÿ>YvBEYÿwrxrwyeÿfG@WgXYeÿz{ÿt{ÿkBGW@ÿ ]Z?BZ`D@WnXÿ 1ÿ bWGpZ`XG?CÿE[ÿ|`EWGWgZWÿ@WnÿbWGpZ`XG?Cÿ_ZnGF@DÿkZW?Z`ÿE[ÿ|`EWGWgZWeÿoZA@`?}ZW?ÿE[ÿc`?BEnEW?GFXeÿ@WvZADZGWÿreÿsÿtmÿ|`EWGWgZWeÿ]Z?BZ`D@WnXÿ. <ÿ bWGpZ`XG?CÿE[ÿ|`EWGWgZWÿ@WnÿbWGpZ`XG?Cÿ_ZnGF@DÿkZW?Z`ÿ|`EWGWgZWeÿoZA@`?}ZW?ÿE[ÿmGE}ZnGF@Dÿ~WgGWZZ`GWgeÿW?EWGYXÿoZYXGWgD@@Wÿreÿsryÿÿ|`EWGWgZWeÿ. ÿ ÿÿÿÿÿÿ ÿÿÿÿ. `?GFDZÿBGX?E`Cÿ O9196994ÿ ÿK9;298<9 ÿ ÿ O996594ÿ
(5) ÿI3/.3 :ÿ
(6) ÿ 0119;294ÿ
(7) ÿI3/.3 :ÿ
(8) ÿ 0936 3< 9ÿ7/ 6/9ÿ ÿI3/.3 :ÿ
(9) ÿ hZCqE`nXÿ 3/178:16/ÿ /P91267/ÿ 0/26<672617 956523/19ÿ R929 7P./1267/3 694ÿ49/4 689 5ÿ K6 99 ÿ/3/7;3 261 95ÿ >?@ABCDEFEFFYXÿ@Y`ZYXÿ. ÿÿÿÿ ÿÿÿÿ. M19ÿ9PP912699ÿ 6P972689ÿ7Pÿ/96ÿ3/26861 7<63 5ÿ./26 ÿ219ÿ3;;93 3/19ÿ7Pÿ219ÿ 52ÿ 956523/2ÿ52 36/5ÿ65ÿ529346 :ÿ 491 9356/0Jÿ61611ÿ46517. 3095ÿ6/19/26995ÿP7 ÿ17889 163 63267/ÿ 9.6 94ÿP7 ÿ1 6/613 ÿ2 3/5 3267/ÿ3/4ÿ3;7ÿ ; 613267/TÿM19 9P7 9Jÿ4999 7;89/2ÿ7Pÿ/96ÿ3/26861 7<63 5ÿ517. 4ÿ/72ÿ7/ :ÿP71.5ÿ7/ÿ<9229 ÿ3/4ÿ<9229 ÿ =6 6/0ÿ7Pÿ3/26861 7<63 7 956523/2ÿ52 36/5Jÿ<.2ÿ35ÿ3ÿ;3 34608ÿ516P2ÿ7/ÿ4999 7;6/0ÿ3/26861 7<63 5ÿ2132ÿ; 97ÿ 99/2ÿ6/4.1267/ÿ7Pÿ 956523/19TÿR929 7P./1267/3 694Jÿ;7 :7386477386/9ÿ20303ÿ49/4 689 5ÿ6621ÿ386497ÿ 17/8.03294ÿ93/178:16/ÿ3/ÿ3/4ÿ6/17 ;7 3294ÿ00ÿ/3/7;3 261 95ÿ002ÿ517694ÿ3ÿÿ 70ÿ 94.1267/ÿ6/ÿ 17 7/:7P7 86/07./625ÿ7Pÿ3ÿ93/178:16/7 956523/2ÿ>?@ABCDEFEFFYXÿ@Y`ZYXÿ52 36/ÿ6/ÿ962 7Jÿ616 9ÿ/72ÿ6/4.16/0ÿ. 956523/19ÿ6/ÿ3ÿ93/178:16/75.519;26< 9ÿ52 36/TÿR93 6/0ÿ7Pÿ3ÿ5.;9 163 ÿ67./4ÿ6/ÿ8619ÿ6/P91294ÿ6621ÿ219ÿ 93/178:16/7 956523/2ÿ>{ÿ@Y`ZYXÿ635ÿ560/613/2 :ÿP3529 ÿ3/4ÿ87 9ÿ9PP912699ÿ<:ÿ6. 603267/ÿ6621ÿ 7674759Jÿ 4.3 717/8.03294ÿ3/7203037002ÿ49/4 689 ÿ5.5;9/567/ÿ213/ÿ<:ÿ6. 603267/ÿ6621ÿ93/178:16/ÿ6/ÿ57 .267/ÿ 7 ÿ3ÿ203037002ÿ49/4 689 ÿ5.5;9/567/TÿR9 96621Jÿ4.3 717/8.03267/ÿ7Pÿ93/178:16/ÿ2709219 ÿ6621ÿ007ÿ 25ÿ6/ÿ1929 7P./1267/3 694ÿ20303ÿ49/4 689 5ÿP. 5ÿ219ÿ/994ÿP7 ÿ/96Jÿ; 7 7/094ÿ 6P972689ÿ3/26861 77ÿ <63 5ÿ=6 6/0ÿ 956523/2ÿ;321709/5ÿ66217.2ÿ6/4.16/0ÿ 956523/19ÿ6/ÿ5.519;26< 9ÿ52 36/5Tÿ8;7 23/2ÿP7 ÿ1 6/613 ÿ 2 3/5 3267/Jÿ2165ÿ<9229 ÿ.59ÿ7Pÿ3/26<672615ÿ13/ÿ<9ÿ31169994ÿ6621ÿ1.. 9/2 :ÿ3;; 7994ÿ3/4ÿ1 6/613 :ÿ3;; 694ÿ 3/26<672615Jÿ; 796494ÿ5.623< 9ÿP7 ÿ38649717/8.03267/Tÿ. ÿ ¡ÿ¢£¤£¥¦¦ÿ K2 6/09/2ÿ 90. 3267/5Jÿ1601ÿ4999 7;89/2ÿ17525ÿ3/4ÿ517 29 ÿ9PP912699ÿ 6P9726895ÿ7Pÿ/96ÿ3/26867ÿ 1 7<63 5ÿ<9P7 9ÿ219ÿ 52ÿ 956523/2ÿ52 36/5ÿ3;;93 Jÿ83=9ÿ4999 7;89/2ÿ7Pÿ/96ÿ3/26861 7<63 5ÿ 17889 163 :ÿ 622 9ÿ322 312699TÿS7/5649 6/0ÿ219ÿ529346 :ÿ517 29/6/0ÿ9PP912699ÿ 6P972689ÿ7Pÿ/799 ÿ 3/26<672615Jÿ4999 7;89/2ÿ7Pÿ/799 ÿ3/26861 7<63 5ÿ517. 4ÿP71.5ÿ7/ÿ6/P91267/717/2 7 ÿ52 3290695ÿ 2132ÿ=6 ÿ6/P91267.5ÿ<3129 63ÿ66217.2ÿ6/4.16/0ÿ<3129 63 ÿ3/26861 7<63 7 956523/19TÿM19ÿ1929 7P./17ÿ 267/3 694ÿ4.3 73/26861 7<63 ÿ49/4 689 5ÿ4951 6<94ÿ6/ÿ2165ÿ52.4:Jÿ=6 94ÿ93/178:16/7 956523/2ÿ 523;1: 717116Jÿ616 9ÿ/72ÿ6/4.16/0ÿ 956523/19ÿ6/ÿ3ÿ93/178:16/75.519;26< 9ÿ52 36/TÿK60/613/2 :Jÿ 21959ÿ1929 7P./1267/3 694ÿ49/4 689 5ÿ13/ÿ<9ÿ; 9;3 94ÿ6621ÿ1.. 9/2 :ÿ3936 3< 9ÿ3/26<672615Tÿ M19 96621ÿ219:ÿ3 76ÿ27ÿ83=9ÿ<9229 ÿ.59ÿ7Pÿ9§6526/0ÿ3/26<672615Jÿ; 796494ÿ389/3< 9ÿ27ÿ386497ÿ 17/8.03267/ÿ3/4ÿ2196 ÿ;32163:ÿ27ÿ1 6/613 ÿ2 3/5 3267/ÿ65ÿ517 2Tÿ. ¨
(10) ÿ0123ÿ3329 63 63ÿ/1Tÿ2.< 65194ÿ<:ÿ© 59969 ÿL24Tÿ M165ÿ65ÿ3/ÿ7;9/ÿ311955ÿ3 261 9ÿ./49 ÿ219ÿSSÿ5Nÿ 619/59ÿÿ122;ª««1 93269917887/5T7 0« 619/595«<:«T«ÿÿ. U S7. 95;7/46/0ÿ3.217 ÿ32ªÿ567894613 ÿ©/06/99 6/0Jÿ¬/699 562:ÿ394613 ÿ19/29 ÿH 7/6/09/Jÿ0/27/6.5ÿ9.56/0 33/ÿ
(11) Jÿ
(12) ÿ0ÿH 7/6/09/JÿM19ÿ9219 3/45Tÿ UU S7. 95;7/46/0ÿ3.217 ÿ32ªÿI63/05.ÿ®9:ÿL3<7 327 :ÿP7 ÿS3 <7/753594ÿ-./126 7/3 ÿ3329 63 5ÿ¯ÿ996195JÿK771176ÿ¬/699 562:Jÿ
(13) ÿO9/°36ÿO4JÿK.17.ÿ
(14) ±
(15) JÿI63/05.Jÿ2TÿOTÿS16/3Tÿ. ~l}@GDÿ@nn`ZXXZXÿ1T1T93/T49 T896².810T/ ÿRTSTÿ93/ÿ49 ÿ396Jÿ8 6.²5.43T94.T1/ÿITÿL6.Tÿ. 122;5ª««476T7 0«
(16) T
(17)
(18) «8T312<67T
(19) T
(20) T ÿ
(21) 7
(22) Ǭ
(23) 01233329 63 63/1T2.< 65194<:© 59969 L24TM165653/7;9/3119553 261 9./49 219SS5N 619/59ÿ122;ª««1 93269917887/5T7 0« 619/595«<:«T«ÿÿ.
(24) 01ÿ345678ÿ91ÿ 4 8ÿ
(25) 1ÿ ÿÿ51ÿ. 5ÿ454545ÿÿ ÿ ÿ. ÿ!"#$%&'(#)%"ÿ *+,-./0+1ÿ023.,-0425ÿ645.ÿ+ÿ5./0475ÿ-8/.+-ÿ-4ÿ879+2ÿ8.+1-8ÿ :;<ÿ +2=ÿ /.64/-.=1>ÿ 023.,-0425ÿ =7.ÿ -4ÿ +2-090,/4?0+1@/.505-+2-ÿ 6+-84A.25ÿ+/.ÿ.B6.,-.=ÿ-4ÿ,+75.ÿ;Cÿ9011042ÿ+227+1ÿ=.+-85ÿ?>ÿ -8.ÿ>.+/ÿDCECÿ:D<ÿFÿG.560-.ÿ42A402Aÿ5./0.5ÿ43ÿ67?10,+-0425ÿ42ÿ2.Hÿ +2=ÿ.I./ÿJ?.--./K+2-090,/4?0+15Lÿ,1020,+1ÿ-/+251+-042ÿ05ÿ5-+1102Aÿ:M<ÿFÿ N-/02A.2-ÿ/.A71+-0425Lÿ80A8ÿ=.I.1469.2-ÿ,45-5ÿ+2=ÿ584/-./ÿ.33.,-0I.ÿ 103.@-09.5ÿ43ÿ2.Hÿ+2-090,/4?0+15ÿ?.34/.ÿ-8.ÿO/5-ÿ/.505-+2-ÿ5-/+025ÿ +66.+/Lÿ9+P.ÿ=.I.1469.2-ÿ43ÿ2.Hÿ+2-090,/4?0+15ÿ,499./,0+11>ÿ10-@ÿ -1.ÿ+--/+,-0I.ÿ:Q<ÿFÿR8./.34/.Lÿ0-ÿ05ÿ7/A.2-ÿ-4ÿO2=ÿ2.Hÿ5-/+-.A0.5ÿ-4ÿ 9+P.ÿ?.--./ÿ75.ÿ43ÿ.B05-02Aÿ+2-090,/4?0+15FÿS-ÿ-8.ÿ5+9.ÿ-09.Lÿ+ÿ 6+/+=0A9ÿ5803-ÿ05ÿ2..=.=ÿ-4ÿ/.94I.ÿ-8.ÿ34,75ÿ43ÿ/.5.+/,8ÿ+2=ÿ=.@ÿ I.1469.2-ÿ.2=.+I4/5ÿ+H+>ÿ3/49ÿ9+P02Aÿ+2-090,/4?0+15ÿ-8+-ÿP011ÿ ?.--./ÿ+2=ÿ?.--./ÿ-4H+/=5ÿ2.Hÿ+2-090,/4?0+15ÿ-8+-ÿ=4ÿ24-ÿ02=7,.ÿ +2-090,/4?0+1@/.505-+2,.ÿ02ÿ?+,-./0+1ÿ6+-84A.25FÿT.5.+/,8ÿ+142Aÿ-8.ÿ 102.5ÿ43ÿ57,8ÿ+ÿ6+/+=0A9ÿ5803-ÿ9+>ÿ?.ÿ94/.ÿ+9.2+?1.ÿ-4ÿ,499./@ÿ ,0+11>ÿ3.+50?1.ÿ9+/P.-02Aÿ+2=ÿ-8./.H0-8ÿ,1020,+1ÿ-/+251+-042Fÿ U+2>ÿ2.HLÿ2+24-.,82414A>@?+5.=ÿ+2-090,/4?0+15ÿ8+I.ÿ?..2ÿ=.@ÿ 5,/0?.=ÿ:E<ÿFÿV+/-0,71+/1>ÿ9.-+1ÿ2+246+/-0,1.5ÿ:WXY<ÿLÿ945-ÿ24-+?1>ÿSAÿ 2+246+/-0,1.5ÿZSA[V5\ÿ:]<ÿ8+I.ÿ-8.ÿ+?010->ÿ-4ÿ=05/76-ÿ,.11ÿ9.9@ÿ ?/+2.5ÿ-8/47A8ÿ-8.ÿ/.1.+5.ÿ43ÿSAÿ0425ÿ:ÿ;CÿLÿ;;ÿ<Fÿ^4H.I./Lÿ42.ÿ43ÿ-8.ÿ 9+02ÿ,8+11.2A.5ÿ02ÿ-8.ÿ+6610,+-042ÿ43ÿSA[V5ÿ05ÿ-4ÿ6/.I.2-ÿ-8.0/ÿ +AA/.A+-042ÿ02ÿ5756.25042Lÿ?.,+75.ÿ+AA/.A+-042ÿ=.,/.+5.5ÿ-8.ÿ+2@ÿ -0?+,-./0+1ÿ+,-0I0->ÿ43ÿSA[V5ÿ:;D<ÿFÿV/.I.2-042ÿ43ÿSA[Vÿ+AA/.A+-042ÿ 8+5ÿ?..2ÿ=42.ÿ7502Aÿ?14,Pÿ,4641>9./5ÿ:;M<ÿLÿ90,.11.5ÿ:;Q<ÿ+2=ÿI.50@ÿ ,1.5ÿ:;E<ÿ+5ÿ+ÿ-.961+-.Lÿ?7-ÿ-.961+-.ÿ5>2-8.505ÿ05ÿ,49610,+-.=ÿ+2=ÿ ,45-1>LÿH80,8ÿ+/.ÿ?4-8ÿ096.=09.2-5ÿ-4ÿ,1020,+1ÿ-/+251+-042FÿG.2@ÿ =/09./5ÿ9+>ÿ6/4I0=.ÿ+ÿA44=Lÿ+1-./2+-0I.ÿ-.961+-.ÿ34/ÿSA[V5FÿV41>@ÿ Z+90=4@+902.\ÿZVSUSU\ÿ=.2=/09./5ÿ+/.ÿ80A81>ÿ?/+2,8.=ÿ=.2=/0-0,ÿ 941.,71.5LÿH0-8ÿ+ÿ/.1+-0I.1>ÿ1+/A.ÿ941.,71+/ÿ9+55Lÿ2+//4Hÿ50_.ÿ=05@ÿ -/0?7-042ÿ+2=ÿ+ÿH.11@=.O2.=ÿA14?71+/ÿ5-/7,-7/.ÿ:ÿ;WÿLÿ;`ÿ<ÿ+2=ÿ8+I.ÿ ?..2ÿ75.=ÿ-4A.-8./ÿH0-8ÿA41=ÿ2+246+/-0,1.5ÿ+5ÿ,42-/+5-ÿ+A.2-5ÿ02ÿ ,4967-./0_.=ÿ-494A/+68>ÿ:;Y<ÿ4/ÿ09972.@5.254/ÿ,4+-02A5ÿ:;]<ÿFÿ VSUSUÿ=.2=/09./5ÿ9+>ÿ-8./.34/.ÿ+154ÿ?.ÿ570-+?1.ÿ+5ÿ+ÿ-.961+-.ÿ 34/ÿSA[V5FÿU4/.4I./Lÿ-8.0/ÿ/.1+-0I.1>ÿ1+/A.ÿ941.,71+/ÿ50_.ÿ24-ÿ421>ÿ .2+?1.5ÿ02,4/64/+-042ÿ43ÿSA[V5ÿ02ÿVSUSUÿ=.2=/09./5Lÿ?7-ÿ+154ÿ ,42a7A+-042ÿ43ÿ+ÿ5.,42=ÿ+2-090,/4?0+1Fÿb42a7A+-042ÿ43ÿ-H4ÿ+2-090@ÿ ,/4?0+15ÿ,+2ÿ?.ÿ.B6.,-.=ÿ-4ÿ/.=7,.ÿ-8.ÿ,8+2,.5ÿ7642ÿ=.I.146@ÿ 9.2-ÿ43ÿ/.505-+2,.@9.,8+20595ÿ02ÿ6+-84A.20,ÿ?+,-./0+ÿ:DC<ÿFÿc+2@ÿ ,49>,02Lÿ+ÿ3/.d7.2-1>ÿ+6610.=ÿ+2-0?04-0,ÿ02ÿ,1020,+1ÿ023.,-042ÿ,42-/41ÿ :ÿD;ÿLÿDDÿ<ÿ8+5ÿ?..2ÿ6/.I04751>ÿ75.=ÿ02ÿ502A1.@,42a7A+-.=ÿ5>5-.95ÿ34/ÿ +2-0?+,-./0+1ÿ+6610,+-042ÿ:DMXDE<ÿFÿc+2,49>,02ÿ,42a7A+-.=ÿ-4ÿVS@ÿ USUÿ=.2=/09./5ÿ=.9425-/+-.=ÿOI.ÿ4/=./5ÿ43ÿ9+A20-7=.ÿ?.--./ÿ -+/A.-02Aÿ-4ÿ?+,-./0+1ÿ,.11ÿ57/3+,.5ÿ-8+2ÿI+2,49>,02ÿ3/..ÿ02ÿ5417@ÿ -042ÿ:DM<ÿFÿ^4H.I./Lÿb840ÿ.-ÿ+1Fÿ:DM<ÿ541.1>ÿ+==/.55.=ÿ-8.ÿ-+/A.-@ÿ 02Aÿ+2=ÿP01102Aÿ.e,+,>ÿ43ÿI+2,49>,02ÿ02ÿ502A1.@,42a7A+-.=ÿVS@ÿ USUÿ=.2=/09./5ÿH0-847-ÿ,42a7A+-042ÿ43ÿ+ÿ5.,42=ÿ+2-090,/4?0+1ÿ4/ÿ .I+17+-042ÿ43ÿ64550?1.ÿ+2-0?04-0,@/.505-+2,.ÿ=.I.14602Aÿ02ÿ-8.ÿ-+/A.-ÿ ?+,-./0+Fÿ R8./.34/.Lÿ-805ÿ6+6./ÿ+095ÿ-4ÿ6/.6+/.ÿ+ÿ8.-./4372,-042+10_.=Lÿ +2-090,/4?0+1ÿ=.2=/09./ÿ-8+-ÿP0115ÿI+2,49>,02@/.505-+2-ÿ5-/+025ÿ +2=ÿ6/.I.2-5ÿ=.I.1469.2-ÿ43ÿI+2,49>,02@/.505-+2,.ÿ02ÿ575,.6-0@ÿ ?1.ÿ5-/+025ÿ-8/47A8ÿ=7+1@,42a7A+-042ÿ43ÿI+2,49>,02ÿ+2=ÿSA[Vÿ-4ÿ VSUSUÿ=.2=/09./5Fÿf8.2ÿ57,,.55371ÿ02ÿ6/.I.2-02Aÿ/.505-+2,.ÿ=.@ÿ I.1469.2-Lÿ8.-./4372,-042+10_.=ÿ=.2=/09./5ÿH0-8ÿ,42a7A+-.=ÿ+2@ÿ -0?04-0,5ÿ+2=ÿSA[V5ÿ02,4/64/+-.=ÿ9+>ÿ+154ÿ?.ÿ75.=ÿ34/ÿ4-8./ÿ.B@ÿ 05-02Aÿ+2-0?04-0,5ÿ+2=ÿ34/9ÿ+ÿ5-097175ÿ34/ÿ-8.ÿ=0/.1>ÿ2..=.=ÿ=.@ÿ I.1469.2-ÿ43ÿ2.Hÿ+2-0?04-0,5ÿH0-8ÿ+ÿ6/4142A.=ÿ.33.,-0I.ÿ103.@ÿ -09.Fÿ*.50=.5ÿ=.5,/06-042ÿ43ÿ-8.ÿ5>2-8.505Lÿ68>50,4@,8.90,+1ÿ,8+/@ÿ +,-./0_+-042ÿ+2=ÿ?04,496+-0?010->ÿ43ÿ-8.ÿ8.-./4372,-042+10_.=ÿ=.2@ÿ =/09./5Lÿ-8.0/ÿP01102Aÿ.e,+,>ÿ-4H+/=5ÿ+ÿI+2,49>,02@/.505-+2-ÿ+2=ÿ 575,.6-0?1.ÿ5-+68>14,4,,+1ÿ5-/+02ÿ+2=ÿ-8.ÿ64-.2-0+1ÿ02=7,-042ÿ43ÿ I+2,49>,02@/.505-+2,.ÿ+A+025-ÿ-8.5.ÿ=7+1@,42a7A+-.=Lÿ+2-090,/4?0+1ÿ =.2=/09./5ÿH011ÿ?.ÿ.I+17+-.=ÿ02ÿI0-/4Fÿg2ÿI0I4ÿ.e,+,>ÿH011ÿ?.ÿ =.9425-/+-.=ÿ02ÿ+ÿ97/02.ÿH472=@023.,-042ÿ94=.1Fÿ. hÿij#k$)jlmÿj"&ÿnk#o%&mÿ 11ÿp545qÿ S902.@-./902+-.=ÿ641>@Z+90=4@+9024\ÿZVSUSU\ÿ=.2=/09./5ÿ43ÿ -8.ÿ347/-8ÿA.2./+-042Lÿ0F.FÿVSUSU@Z[^ÿDÿ\ÿWQÿLÿH./.ÿ4?-+02.=ÿ3/49ÿbrÿ G.2=/09./ÿR.,82414A>ÿb4FLÿs-=FÿZf.08+0Lÿb802+\ÿ+5ÿEÿH-tÿ9.-8+241ÿ 5417-0425Fÿc+2,49>,02ÿZc+2\ÿ8>=/4,814/0=.Lÿ;@:?05ÿZ=09.-8>1+9024\ÿ 9.-8>1.2.<ÿu;^@;LDLM@-/0+_414ÿ:QLE@?<ÿ6>/0=02079ÿM@4B0=ÿ8.B+v74@ÿ /4684568+-.ÿZ^SRw\Lÿ+2=ÿ[L[@=00546/46>1.-8>1+902.ÿZGgxS\ÿH./.ÿ 67/,8+5.=ÿ 3/49ÿ yz{ÿ N,0.2-0O,ÿ s-=Fÿ ZN8+2A8+0Lÿ b802+\Fÿ S28>@ÿ =/475ÿ[Lÿ[@=09.-8>134/9+90=.ÿZGU|\ÿ+2=ÿ=09.-8>1ÿ57134B0=.ÿ ZGUN}\ÿH./.ÿ67/,8+5.=ÿ3/49ÿN0A9+@S1=/0,8ÿZ*.0a02ALÿb802+\Fÿ s0I.~=.+=ÿ?+,-./0+1ÿc0+?010->ÿ{0-ÿH+5ÿ67/,8+5.=ÿ3/49ÿR8./94ÿ |058./ÿZ*.0a02ALÿb802+\FÿR/>6-0,ÿN4>ÿ?/4-8ÿZRN*\ÿ+2=ÿR/>6-0,+5.ÿ N4>ÿSA+/ÿZRNS\ÿH./.ÿ4?-+02.=ÿ3/49ÿ^+2A_847ÿU0,/4?0+1ÿT.+A.2-ÿ b4FLÿs-=ÿZ^+2A_847Lÿb802+\FÿN4=079ÿ?4/48>=/0=.ÿZ[+*^ÿQÿ\Lÿ501@ÿ I./ÿ20-/+-.ÿZSA[}ÿMÿ\LÿM@ZQLE@=09.-8>1@D@-80+_41>1\ÿuDLE@=068.2>1@D@ÿ ^@-.-/+_41079ÿ?/490=.ÿZURR\ÿ+2=ÿ54=079ÿ,814/0=.ÿZ[+b1\ÿH./.ÿ 67/,8+5.=ÿ3/49ÿb8.90,+1ÿg2=75-/0+1ÿb4FÿZN8+2A8+0Lÿb802+\FÿG0+1>505ÿ ?+A5ÿH0-8ÿ941.,71+/ÿH.0A8-ÿ,7-@433+-ÿECCÿ+2=ÿMCÿCÿCÿH./.ÿ6/4I0=.=ÿ ?>ÿN8+2A8+0ÿr7+2>.ÿ*04-.,82414A>ÿb4/64/+-042ÿZN8+2A8+0Lÿb802+\Fÿ 11ÿ5546ÿÿq4676 75ÿ 56ppÿ64qÿ c+2@VSUSUÿ =.2=/09./5ÿ H./.ÿ 5>2-8.50_.=ÿ I0+ÿ +90=.@ÿ ,42a7A+-042ÿ :DM<ÿFÿ */0.v>Lÿ I+2,49>,02ÿ 8>=/4,814/0=.ÿ 8>=/+-.ÿ ZDMÿ9ALÿCFC;Eÿ9941\ÿ+2=ÿ^SRwÿZ;Dÿ9ALÿCFCMÿ9941\ÿH./.ÿ=05@ÿ 541I.=ÿ02ÿ+ÿ90B-7/.ÿ43ÿ+28>=/475ÿGUN}ÿZDÿ9s\ÿ+2=ÿGU|ÿZ;ÿ9s\ÿ -4ÿ34/9ÿ+ÿ8494A.2.475ÿ5417-042FÿGgxSÿZ;CÿsLÿCFCMÿ9941\ÿH+5ÿ +==.=ÿ02-4ÿ-8.ÿ5417-042ÿ72=./ÿ9+A2.-0,ÿ5-0//02AFÿVSUSUÿ=.2@ÿ =/09./5ÿZD`ÿ9ALÿCFCC;]ÿ9941\ÿH./.ÿ5756.2=.=ÿ02ÿEÿ9sÿ+28>=/475ÿ GU|ÿ+2=ÿ-8.ÿ/.571-02Aÿ5756.25042ÿ+==.=ÿ-4ÿ-8.ÿ/.+,-042ÿ90B-7/.ÿ +2=ÿP.6-ÿ+-ÿ/449ÿ-.96./+-7/.ÿ34/ÿDQÿ8FÿR8.2Lÿ0,.@,41=ÿ.-8>1ÿ .-8./ÿH+5ÿ+==.=ÿ-4ÿ6/.,060-+-.ÿc+2@VSUSUÿ=.2=/09./5Fÿ|02+11>Lÿ -8.ÿ6/.,060-+-.ÿH+5ÿ67/0O.=ÿ?>ÿ=0+1>505ÿ+A+025-ÿ=05-011.=ÿH+-./ÿ-4ÿ /.94I.ÿ242@,42a7A+-.=ÿI+2,49>,02ÿ+2=ÿ1>468010_.=ÿ-011ÿ37/-8./ÿ .B6./09.2-5Fÿ 11ÿ5546ÿÿq4676 75ÿpp7ÿ56ÿ 56 758ÿ 64654ÿ 56pp7ÿ64qÿ N02A1.@,42a7A+-.=ÿVSUSU@SAÿ=.2=/09./5ÿH./.ÿ6/.6+/.=ÿ+5ÿ 6/.I04751>ÿ=.5,/0?.=ÿ:DW<ÿFÿSA[}ÿMÿZMÿ9sLÿWÿ9A~9sÿ02ÿH+-./\ÿ+2=ÿ VSUSUÿ=.2=/09./5ÿZ;Dÿ9sLÿQF`Eÿ9A~9sÿ+154ÿ02ÿH+-./\ÿH./.ÿ+==.=ÿ -4ÿ+ÿECÿ9sÿ/472=ÿv+5Pÿ72=./ÿI0A4/475ÿ5-0//02Aÿ34/ÿ;ÿ8Fÿ[+*^ÿQÿ5417@ÿ -042ÿZMÿ9sLÿDFEÿ9A~9s\ÿ=05541I.=ÿ02-4ÿ+ÿH+-./X9.-8+241ÿZD;ÿI~I\ÿ 90B-7/.LÿH+5ÿ514H1>ÿ+==.=ÿ-4ÿ-8.ÿSAÿ5+1-@VSUSUÿ=.2=/09./ÿ90B@ÿ -7/.ÿ72=./ÿ5-0//02AFÿS3-./ÿ5-0//02Aÿ34/ÿDÿ8Lÿ/.571-02AÿVSUSU@SA[Vÿ =.2=/09./5ÿH./.ÿ=0+1>_.=ÿ+A+025-ÿ=05-011.=ÿH+-./ÿ-4ÿ/.94I.ÿ.B,.55ÿ [+*^ÿQÿ+2=ÿSA[}ÿMÿ+2=ÿ3/.._.@=/0.=ÿ34/ÿ37/-8./ÿ.B6./09.2-5Fÿ |4/ÿ-8.ÿ6/.6+/+-042ÿ43ÿ=7+1@,42a7A+-.=Lÿ8.-./4372,-042+10_.=ÿ c+2@VSUSU@SA[Vÿ=.2=/09./5Lÿc+2ÿZDMÿ9ALÿCFC;Eÿ9941\ÿH+5ÿ=05@ÿ 541I.=ÿ02ÿ-8.ÿ^SRw~GgxSÿ90B-7/.Lÿ+5ÿ=.5,/0?.=ÿ+?4I.ÿ+2=ÿVSUSU@ÿ SA[Vÿ=.2=/09./5ÿ5756.2=.=ÿ02ÿQÿ9sÿGU|ÿZDYÿ9AÿVSUSUÿ.d70I@ÿ +1.2-ÿ,42,.2-/+-042LÿCFCCDÿ9941\ÿH./.ÿ+==.=FÿS3-./ÿ/.+,-042ÿ34/ÿ DQÿ8ÿ+-ÿ/449ÿ-.96./+-7/.Lÿ/.571-02Aÿ=7+1@,42a7A+-.=ÿc+2@VSUSU@ÿ SA[V ÿ=.2=/09./5ÿH./.ÿ=0+1>_.=ÿ+A+025-ÿ=05-011.=ÿH+-./ÿ+2=ÿ5-4/.=ÿ +-ÿQÿCÿbFÿ 1 1ÿ64ÿ554546ÿ S11ÿ=.2=/09./5ÿZYÿ9Aÿ43ÿ.+,8ÿ=.2=/09./\ÿH./.ÿ5756.2=.=ÿ02ÿ CFEÿ9sÿGÿDÿ}ÿH+-./ÿ34/ÿ;ÿ^ÿ[UTÿ56.,-/45,46>ÿ+-ÿQCCÿU^_ÿ42ÿ+ÿ */P./ÿG0A0-+1ÿ[UTÿ56.,-/49.-./Fÿ. DM;ÿ.
(26) 01ÿ345678ÿ91ÿ 4 8ÿ
(27) 1ÿ ÿÿ51ÿ. 5ÿ454545ÿÿ ÿ ÿ. !"#ÿ$ÿ %&'&()*ÿ+',&-&./01ÿ2/'34'.0).&/'5ÿ6%+257ÿ/8ÿ91ÿ5 9ÿ:;22<=>??ÿ6@)'3/(13&'A5B534C.&-*47ÿ)'Dÿ91ÿ5 9ÿE4'F>ÿ 6@)'3/(13&'A045&5.)'.7ÿ)G)&'5.ÿ@)'3/(13&'Hÿ:GIJ5ÿ)'DÿD&88404'.ÿD4'D0&(405Kÿ%+2ÿ@)*B45ÿ)04ÿ4LC04554Dÿ&'ÿM)'ÿ/0ÿ:Gÿ 4NB&@)*4'.ÿ3/'34'.0).&/'5Kÿ:**ÿ4LC40&(4'.5ÿO404ÿD/'4ÿ&'ÿ.0&C*&3).4Hÿ1&4*D&'Gÿ&D4'.&3)*ÿ045B*.5ÿB'*455ÿ&'D&3).4Dÿ/.,40O&54Kÿ 91ÿ5 9ÿ:;22<=>??ÿ 91ÿ5 9ÿE4'F>ÿ :'.&(&30/-&)*ÿ %+26M)'ÿPGQ(R7ÿ %+26:GIJÿPGQ(R7ÿ %+26M)'ÿPGQ(R7ÿ %+26:GIJÿPGQ(R7ÿ Tÿ I:ÿ M)'3/(13&'ÿ =ÿ I:ÿS :GIJ5ÿ I:ÿ F=ÿ I:ÿ F=ÿ M)'AJ:%:%ÿD4'D0&(405ÿ <=Tÿ I:ÿ F=Q<=TQ=U>ÿ I:ÿ J:%:%A:GIJÿD4'D0&(405ÿ I:ÿ F=ÿ I:ÿ F=ÿ =ÿ <ÿ M)'AJ:%:%A:GIJÿD4'D0&(405ÿ =ÿ <ÿ S I:ÿD4'/.45ÿ'/.ÿ)CC* &3)-*4Kÿ. V4.)ÿC/.4'.&)*5ÿ/8ÿ.,4ÿD&88404'.ÿD4'D0&(405ÿO404ÿ(4)5B04Dÿ&'ÿ D4A&/'&W4DÿO).40ÿ)'Dÿ&'ÿC,/5C,).4ÿ-B88404Dÿ5)*&'4ÿ6JXYZÿ=K?ÿ(%ÿ [\ÿ=ÿJ]ÿ^ÿHÿTK?ÿ(%ÿI)ÿ=ÿ\J]ÿ^ÿHÿU?ÿ(%ÿI)2*Hÿ=K_ÿ(%ÿ[2*7ÿ).ÿC\ÿ_K^ÿ B5&'Gÿ)ÿV4.)5&W40ÿI)'/ÿVYÿ6%)*@40'ÿ+'5.0B(4'.5Hÿ`[7KÿY&(B*.)'4Aÿ /B5*1Hÿ/'ÿ.,4ÿ5)(4ÿ&'5.0B(4'.Hÿ.,4ÿD&)(4.40ÿD&5.0&-B.&/'ÿ/8ÿ.,4ÿ D&88404'.ÿD4'D0&(405ÿ&'ÿJXYÿO)5ÿD4.40(&'4DÿB5&'Gÿa1')(&3ÿR&G,.ÿ Y3)..40&'GKÿ %/*43B*)0ÿ3/(C/5&.&/'ÿ/8ÿ.,4ÿD&88404'.ÿD4'D0&(405ÿO)5ÿ(4)Aÿ 5B04DÿB5&'Gÿb/B0&40ÿ;0)'58/0(A+'80)ÿc4Dÿ6b;A+c7ÿ5C43.0/(4.01Kÿb/0ÿ b;A+cÿ5C43.0/53/C1HÿD4'D0&(405ÿ6=ÿ(G7ÿO404ÿ(&L4DÿO&.,ÿ=??ÿ(Gÿ [X0ÿO&.,ÿ)ÿ(/0.)0ÿ)'DÿC45.*4Hÿ)'DÿC04554Dÿ./ÿ/-.)&'ÿ)ÿ.0)'5C)04'.ÿ [X0ÿC4**4.Kÿb;A+cÿ(4)5B04(4'.5ÿO404ÿC408/0(4DÿO&.,ÿ)ÿ\dJec+]Iÿ YC43.0/(4.4h< 0ÿ6X0Bf40Hÿe..*&'G4'Hÿg40()'17ÿ&'ÿ.,4ÿ0)'G4ÿ80/(ÿ^??ÿ ./ÿ^?ÿ?ÿ?ÿ3(ÿ ÿ.)f&'GÿFUÿ53)'5ÿ8/0ÿ4)3,ÿ5C43.0B(Kÿ;,4ÿ5C43.0/(Aÿ 4.40ÿO)5ÿ4L.4'5&@4*1ÿCB0G4DÿO&.,ÿ'&.0/G4'h<ÿ-ÿ48/04ÿ.)f&'Gÿ5C43.0)Kÿ YC43.0)ÿO404ÿ.)f4'ÿ).ÿ)ÿ045/*B.&/'ÿ/8ÿ^ÿ3(ÿ HÿB5&'GÿO4)fÿ)C/D&W)Aÿ .&/'ÿ)'DÿB5&'Gÿ.,4ÿ5C43.0B(ÿ/8ÿ)ÿ[X0ÿ.)-*4.ÿ)5ÿ)ÿ-)3fG0/B'Dÿ.,).ÿ O)5ÿ5B-.0)3.4Dÿ80/(ÿD4'D0&(40ÿ5C43.0)Kÿ 1i1ÿj46546ÿkÿl56m46ÿ56nÿ7ÿ66ÿ46ÿn6n49ÿ ;,4ÿ@)'3/(13&'ÿ3/'.4'.ÿ&'ÿ.,4ÿD&88404'.ÿD4'D0&(405ÿ/0ÿ&'ÿ5/Aÿ *B.&/'ÿO404ÿD4.40(&'4DÿB5&'Gÿ`MoM&5ÿ5C43.0/53/C1ÿ6J40f&'ÿe*(40ÿ R)(-D)ÿ=Uÿ`MoM&5ÿ5C43.0/(4.407Hÿ)5ÿD/'4ÿ)'DÿD4530&-4Dÿ-48/04ÿ &'ÿD4.)&*ÿ-1ÿ/.,405ÿp=Fo=UqÿKÿb&05.Hÿ)ÿ3/'34'.0).&/'ÿ540&45ÿ/8ÿ@)'Aÿ 3/(13&'ÿ&'ÿD4A&/'&W4DÿO).40ÿO)5ÿC04C)04DHÿ)8.40ÿO,&3,ÿ)-5/0CAÿ .&/'ÿ5C43.0)ÿO404ÿ043/0D4Dÿ)'Dÿ)ÿ3)*&-0).&/'ÿ3B0@4ÿ()D4ÿ-1ÿC*/.Aÿ .&'Gÿ.,4ÿ&'.4'5&.&45ÿ/8ÿ.,4ÿ3,)0)3.40&5.&3ÿ)-5/0C.&/'ÿC4)fÿ/8ÿ@)'Aÿ 3/(13&'ÿ6=T?ÿ'(7ÿ)G)&'5.ÿ@)'3/(13&'ÿ3/'34'.0).&/'Kÿ;,4ÿ3)*&-0)Aÿ .&/'ÿ3B0@4ÿ3/B*Dÿ-4ÿD&043.*1ÿB54Dÿ&'ÿ3)54ÿ/8ÿ@)'3/(13&'ÿ&'ÿ5/*B.&/'ÿ /0ÿM)'AJ:%:%ÿD4'D0&(405ÿ&'ÿ5B5C4'5&/'Kÿ+'ÿ3)54ÿ/8ÿ3)*3B*).&'Gÿ .,4ÿ@)'3/(13&'ÿ3/'34'.0).&/'ÿ&'ÿDB)*A3/'rBG).4DHÿ,4.40/8B'3.&/'Aÿ )*&W4DÿM)'AJ:%:%A:GIJÿD4'D0&(405Hÿ.,4ÿ=T?ÿ'(ÿ)-5/0-)'34ÿDB4ÿ ./ÿ:GIJ5ÿ)5ÿ/33B00&'Gÿ&'ÿ.,4ÿ5C43.0B(ÿ/8ÿJ:%:%A:GÿD4'D0&(405ÿ ,)Dÿ./ÿ-4ÿ5B-.0)3.4DKÿ ;,4ÿ3/'.4'.ÿ/8ÿ:Gÿ&'ÿ,4.40/8B'3.&/')*&W4DÿM)'AJ:%:%A:GIJÿ D4'D0&(405ÿO)5ÿD4.40(&'4Dÿ-1ÿ&'DB3.&@4*1ÿ3/BC*4DÿC*)5()ÿ()55ÿ 5C43.0/(4.01ÿ6:B0/0)ÿ%s?Hÿt4')ÿ;43,'/*/G&45Hÿg40()'17Kÿ 1u1ÿ545ÿ 467ÿ56nÿv5l9467ÿ M)'3/(13&'A5B534C.&-*4ÿ91ÿ5 9ÿ:;22<=>??ÿ)'Dÿ@)'3/(13&'Aÿ 045&5.)'.ÿp=_qÿ91ÿ5 9ÿE4'F>ÿ6J40f&'e*(40ÿ+'3KHÿw)*.,)(Hÿ%:Hÿ `Y:7ÿO404ÿB54Dÿ&'ÿ.,&5ÿ5.BD1ÿ6544ÿ;)-*4ÿ<ÿ7KÿX/.,ÿ5.0)&'5ÿO404ÿ3B*Aÿ .B04Dÿ/'ÿ;Y:Hÿ5BCC*4(4'.4DÿO&.,ÿ=??ÿPGQ(Rÿf)')(13&'ÿ&'ÿ3)54ÿ/8ÿ 91ÿ5 9ÿE4'F>Kÿ:ÿ5&'G*4ÿ3/*/'1ÿ/8ÿ4)3?,ÿÿ5.0)&'ÿO)5ÿ.0)'584004Dÿ&'./ÿ <?ÿ(Rÿ;YXÿ)'DÿG0/O'ÿ8/0ÿ=^ÿ,ÿ).ÿF_ÿ2ÿ&'ÿ)(-&4'.ÿ)&0Kÿ;,4'Hÿ<??ÿ PRÿ/8ÿ.,&5ÿC043B*.B04ÿO)5ÿ)DD4Dÿ./ÿ<?ÿ(Rÿ;YXÿ)'Dÿ3B*.B04Dÿ8/0ÿ)'Aÿ /.,40ÿ<>ÿ,Kÿ:8.40ÿ<>ÿ,Hÿ.,4ÿ5.)CTÿ,1*/3/33)*ÿ3B*.B045ÿO404ÿ4&.,40ÿD&Aÿ 043.*1ÿD&*B.4Dÿ&'ÿ;YXÿ./ÿ<ÿx<?ÿ 3/*/'1ÿ8/0(&'GÿB'&.5ÿ62b`7Q(Rÿ8/0ÿ. )'.&-)3.40&)*ÿ)3.&@&.1ÿ)55)15ÿ/0ÿ5B5C4'D4Dÿ)8.40TÿÿO)5,&'Gÿ)'Dÿ34'Aÿ .0&8BG).&/'ÿ&'ÿJXYÿ).ÿ)ÿ3/'34'.0).&/'ÿ/8ÿ<ÿx<?ÿ 2b`Q(RHÿ)5ÿD4.40Aÿ (&'4Dÿ-1ÿ540&)*ÿD&*B.&/'ÿ)'DÿC*).4ÿ3/B'.&'Gÿ/8ÿ2b`5ÿG0/O'ÿ/'ÿ;Y:ÿ C*).45Kÿ 1y1ÿ64z545ÿ54l4mÿkÿn6n49ÿ b/0ÿ)'.&-)3.40&)*ÿ)3.&@&.1ÿ)55)15Hÿ{05.ÿ(&'&()*ÿ&',&-&./01ÿ3/'Aÿ 34'.0).&/'5ÿ6%+257ÿ/8ÿ@)'3/(13&'ÿ8044ÿ&'ÿ5/*B.&/'ÿ)'DÿD&88404'.ÿ J:%:%ÿD4'D0&(40ÿ5B5C4'5&/'5ÿO404ÿ(4)5B04Dÿ-1ÿ()f&'Gÿ.O/Aÿ 8/*Dÿ540&)*ÿD&*B.&/'5Kÿ<??ÿPRÿ/8ÿ.,454ÿD&*B.&/'5ÿ&'ÿs>ÿO4**AC*).45ÿ O404ÿ5BCC*4(4'.4DÿO&.,Uÿÿ<??ÿPRÿ5.)C,1*/3/33)*ÿ5B5C4'5&/'5ÿ&'ÿ ;YX?ÿÿ6D&*B.4Dÿ./ÿ<ÿx <?ÿ 2b`Q(R7ÿ)'Dÿ&'3B-).4Dÿ8/0ÿ=^ÿ,ÿ).ÿ F_ÿ2Kÿ%+2ÿ@)*B45ÿO404ÿ.)f4'ÿ)5ÿ.,4ÿ*/O45.ÿ3/'34'.0).&/'ÿ/8ÿ@)'Aÿ 3/(13&'ÿ&'ÿ5/*B.&/'ÿ)'DÿD4'D0&(405ÿ&'ÿ5B5C4'5&/'ÿ'/.ÿ5,/O&'Gÿ )'1ÿ@&5&-*4ÿG0/O.,Hÿ&K4Kÿ.B0-&D&.1Kÿ%+2ÿ@)*B45ÿO404ÿ)**ÿ(4)5B04Dÿ&'ÿ .0&C*&3).4Kÿ +'ÿ)ÿ543/'Dÿ)'.&-)3.40&)*ÿ)3.&@&.1ÿ)55)1Hÿ<??ÿPRÿ/8ÿ)ÿ5.)C,1*/Aÿ 3/33)*ÿ5B5C4'5&/'ÿ&'ÿ;YXÿ6<ÿx <?ÿTÿ2b`Q(R7ÿO)5ÿ(&L4DÿO&.,ÿ<??ÿ PRÿ/8ÿ@)'3/(13&'ÿ8044ÿ&'ÿ5/*B.&/'ÿ/0ÿD&88404'.ÿJ:%:%ÿD4'D0&(40ÿ 5B5C4'5&/'5ÿ&'ÿJXYÿBCÿ./ÿM)'ÿ)'Dÿ:Gÿ4NB&@)*4'.ÿ3/'34'.0).&/'5ÿ/8ÿ F=?ÿÿPGQ(Rÿ)'Dÿ<>ÿPGQ(RHÿ045C43.&@4*1ÿ)'Dÿ&'3B-).4Dÿ8/0ÿ=KUÿ,ÿ).ÿ F_ÿ2Kÿ:8.40ÿ&'3B-).&/'Hÿ?K=ÿ(Rÿ)*&NB/.5ÿO404ÿ540&?)ÿ**1ÿD&*B.4Dÿ&'ÿ;YXHÿ C*).4Dÿ/'./ÿ;Y:ÿ)G)0ÿ)'Dÿ3B*.B04Dÿ8/0ÿ=^ÿ,ÿ).ÿF_ÿ2Hÿ)8.40ÿO,&3,ÿ.,4ÿ 'B(-40ÿ/8ÿ2b`ÿO404ÿ3/B'.4DKÿ 1|1ÿj69546ÿkÿÿ}5ÿ56nÿz56ÿn557ÿ 24**ÿO)**ÿD)()G4ÿ./ÿ5.)C,1*/3/33&ÿDB0&'Gÿ4LC/5B04ÿ./ÿ@)'Aÿ 3/(13&'ÿ8044ÿ&'ÿ5/*B.&/'ÿ/0ÿD&88404'.ÿJ:%:%ÿD4'D0&(40ÿ5B5Aÿ C4'5&/'5ÿO)5ÿ)554554Dÿ.,0/BG,ÿ53)''&'Gÿ4*43.0/'ÿ(&30/53/C1Kÿ %4(-0)'4ÿD)()G4ÿO)5ÿ)554554DÿB5&'Gÿ)ÿR&@4Qa4)DÿM&)-&*&.1ÿ[&.ÿ 6;,40(/ÿb&5,40HÿX4&r&'GHÿ2,&')7Kÿ:*.,/BG,ÿ3)**4Dÿ)ÿR&@4Qa4)Dÿ@&)-&*Aÿ &.1ÿ)55)1Hÿ.,4ÿ)55)1ÿ&5ÿ-)54Dÿ/'ÿ.,4ÿ&')-&*&.1ÿ/8ÿ.,4ÿ04DA~B/04534'.ÿ 5.)&'ÿC0/C&D&B(ÿ&/D&D4ÿ./ÿ4'.40ÿ-)3.40&)ÿO&.,ÿ&'.)3.ÿ34**ÿ(4(Aÿ -0)'45ÿ)'DÿD&5C*)34ÿY1./sÿ.,).ÿ4'.405ÿ-/.,ÿ&'.)3.ÿ)5ÿO4**ÿ)5ÿD)(A ÿ )G4Dÿ(4(-0)'45ÿp=TqÿKÿb/0ÿ5.)&'&'GHÿ5.)C,1*/3/33&ÿ&'ÿJXYÿ6<ÿx <?ÿTÿ 2b`Q(R7ÿO404ÿ(&L4DÿO&.,ÿ4NB)*ÿ@/*B(45ÿ/8ÿ@)'3/(13&'ÿ8044ÿ&'ÿ 5/*B.&/'ÿ/0ÿ&'ÿ)ÿD4'D0&(40ÿ5B5C4'5&/'ÿ).ÿD&88404'.ÿM)'ÿ4NB&@)Aÿ *4'.ÿ3/'34'.0).&/'5Kÿ:8.40ÿ=KUÿ,ÿ4LC/5B04Hÿ5B5C4'5&/'5ÿO404ÿ34'Aÿ .0&8BG4DHÿ5BC40').)'.5ÿ04(/@4DHÿ)'Dÿ5.)C,1*/3/33&ÿ04A5B5C4'D4Dÿ &'ÿJXYKÿI4L.ÿFÿRÿ/8ÿ)ÿ<<ÿ(&L.B04ÿ/8ÿY1./sÿ)'DÿC0/C&D&B(ÿ&/Aÿ D&D4ÿO)5ÿ)DD4Dÿ./ÿ<ÿ(Rÿ/8ÿ)ÿ5.)C,1*/3/33)*ÿ5B5C4'5&/'ÿ)'Dÿf4C.ÿ 8/0ÿ<Uÿ(&'ÿ&'ÿ.,4ÿD)0fÿ).ÿ0//(ÿ.4(C40).B04Kÿ:8.40ÿO)5,&'Gÿ.,044ÿ .&(45ÿ&'ÿJXYHÿ5.)C,1*/3/33&ÿO404ÿ&()G4DÿB5&'Gÿ3/'8/3)*ÿ*)540ÿ53)'Aÿ '&'Gÿ(&30/53/C1ÿ62RY%ZÿV4&55ÿ3/'8/3)*ÿ(&30/53/C4Hÿ4NB&CC4DÿO&.,ÿ )ÿ>Fÿx/-r43.&@4ÿ*4'57Kÿ :8.40ÿ5&(&*)0ÿ4LC/5B04ÿ./ÿ@)'3/(13&'ÿ/0ÿD&88404'.ÿJ:%:%ÿD4'Aÿ D0&(405ÿ).ÿM)'ÿ)'Dÿ:Gÿ4NB&@)*4'.ÿ3/'34'.0).&/'5ÿ/8ÿ=ÿPGQ(Rÿ)'Dÿ <ÿPGQ(RHÿ045C43.&@4*1Hÿ5.)C,1*/3/33)*ÿ34**ÿO)**5ÿO404ÿ@&5B)*&W4DÿB5Aÿ. =F=ÿ.
(28) 01ÿ345678ÿ91ÿ 4 8ÿ
(29) 1ÿ ÿÿ51ÿ. 5ÿ454545ÿÿ ÿ ÿ. !ÿ"#$ !ÿ%&%#'() ÿ* #()"#)+,ÿ-./01ÿ2% ""ÿ.3+($ÿ445ÿ6$(&ÿ2% ""5ÿ >$ CYR0R0CR!ZYÿ"3"+% " ) "ÿD$"ÿ"3P"%`3% '&,ÿ#$&$'%9ÿ$#Cÿ 7%(*$ ,8ÿ)+%($'%9ÿ$'ÿ$ ÿ$##%&%($' !ÿ:)&'$!%ÿ);ÿ<ÿ=>?ÿ@)ÿ'A "ÿ% 95ÿ #)(9 !ÿ')ÿUIJVÿ "'$+A,&)#)## ÿ$;'%(ÿ%B+)"3(%ÿ')ÿ:$ #)*,# ÿ;(%%ÿ ÿ")&3' ) ÿ)(ÿ9% Cÿ o ÿcQ4QG ÿÿ 9( *%(ÿ"3"+% " ) "ÿD%(%ÿEB%9ÿD 'AÿFGÿ!&3'$($&9%A,9%ÿ;)(ÿHÿA5ÿ p ÿ ÿ uÿÿqÿÿ
(30) 4ÿ6vÿHJJÿsÿQ54ÿ6ÿtVÿÿiHJJGÿ -H8ÿ U ÿ q ÿ r6rÿ 4ÿsÿ Q54ÿ 6ÿt !($93$&&,ÿ9%A,9($'%9ÿD 'Aÿ%'A$ )&ÿ-IJ5ÿ4J5ÿ<45ÿK45ÿ$ 9ÿHJJG85ÿ%$#Aÿ #) #% '($' ) ÿ;)(ÿH4ÿ* ?ÿL%A,9($'%9ÿ"$*+&%"ÿD%(%ÿ+&$#%9ÿ) ÿMCÿ ÿDA #AÿRÿ(%;%("ÿ')ÿ'A%ÿ$P")(P$ #%"ÿ);ÿ'A%ÿ9 ;;%(% '&,ÿE&&%9ÿD%&&"?ÿ 9 3*ÿ@ ÿNB 9%ÿ-M@N8ÿ"& 9%"ÿ;)(ÿ* #()"#)+,?ÿ 11ÿw6xrÿy 6rz{5467ÿ46ÿ4ÿ 1O1ÿL%:%&)+*% 'ÿ);ÿ:$ #)*,# C(%" "'$ #%ÿ ÿ$ÿ d%$& !ÿ);ÿ ;%#'%9ÿ"3+%(E# $&ÿD)3 9"ÿP,ÿ'(%$'*% 'ÿD 'Aÿ :$ #)*,# C"3"#%+' P&%ÿ91ÿ5 Qÿ " !&%C#) W3!$'%9ÿYR0R0CR!ZYÿ)(ÿ93$&C#) W3!$'%95ÿA%'%();3 #Cÿ ' ) $& X%9ÿ>$ CYR0R0CR!ZYÿ9% 9( *%("ÿD$"ÿ#)*+$(%9ÿD 'Aÿ#& Cÿ >$ #)*,# C"3"#%+' P&%ÿ91ÿ5 QÿR@66HSTJJÿD$"ÿ3"%9ÿ')ÿ%:$&Cÿ #$&&,ÿ$++& %9ÿ:$ #)*,# ÿ (( !$' ) ÿ ÿTmgÿD%%="ÿ)&9ÿ_R^_]#ÿ;%Cÿ 3$'%ÿ+)"" P&%ÿ 93#' ) ÿ);ÿ:$ #)*,# C(%" "'$ #%ÿ3+) ÿ9$ &,5ÿ"%Cÿ *$&%ÿ* #%ÿ-$:%($!%ÿD% !A'ÿSJÿ!8?ÿ0 #%ÿD%(%ÿ+(): 9%9ÿP,ÿ'A%ÿ ( $&ÿ"3PC#3&'3( !ÿUSKVÿ ÿ'A%ÿ+(%"% #%ÿ);ÿ:$ #)*,# ÿ;(%%ÿ ÿ")Cÿ 0)9%&ÿR *$&ÿe%"%$(#Aÿ6% '%(ÿ);ÿ.))#A)Dÿ\ :%(" ',ÿ-.3XA)35ÿ &3' ) ÿ)(ÿ93$&C#) W3!$'%95ÿA%'%();3 #' ) $& X%9ÿ>$ CYR0R0C R!ZYÿ 6A $8ÿ$ 9ÿ%B+%( *% '"ÿ+%(;)(*%9ÿ ÿ$##)(9$ #%ÿD 'Aÿ'A%ÿ!3 9%Cÿ 9% 9( *%(ÿ"3"+% " ) "?ÿ[ ("'ÿ$ÿ"'$+A,&)#)##$&ÿ#3&'3(%ÿ-HJÿ4ÿ6[\]*^8ÿ & %"ÿ$ 9ÿD 'Aÿ'A%ÿ$++():$&ÿ-0$,ÿSS 95ÿSJSJ8ÿ);ÿ'A%ÿM"' '3' ) $&ÿ ÿ@._ÿD$"ÿ!()D ÿ;)(ÿSFÿAÿ ÿ'A%ÿ+(%"% #%ÿ);ÿ"3PC0M6ÿ#) #% '($Cÿ R *$&ÿ6$(%ÿ$ 9ÿ\"%(ÿ6)** ''%%ÿ$'ÿ.))#A)Dÿ\ :%(" ',?ÿ0 #%ÿ ' ) "ÿ);ÿ:$ #)*,# ÿ ÿ")&3' ) ÿ)(ÿ>$ CYR0R0CR!ZYÿ9% 9( *%("ÿ D%(%ÿ($ 9)*&,ÿ9 : 9%9ÿ ')ÿ;)3(ÿ!()3+"5ÿ #&39 !ÿ$ÿY_.ÿ#) '()&ÿ ÿ"3"+% " ) ?ÿ@A%ÿE("'ÿ"3PC0M6ÿ#) #% '($' ) "ÿ$++& %9ÿD%(%ÿH]HTÿ -4ÿ* #%ÿ+%(ÿ!()3+8?ÿ );ÿ'A%ÿ0M6ÿJÿ$"ÿ;)3 9ÿ ÿ$P"% #%ÿ);ÿ'A%ÿ$ ' * #()P $&ÿ-"%%ÿ$&")ÿ R;'%(ÿ"A$: !ÿ$ 9ÿ9 " ;%#' ) ÿ);ÿ'A%ÿ"= ÿ-<4Gÿ%'A$ )&85ÿ$ÿ"= ÿ @$P&%ÿHÿ8?ÿ.3P"%`3% '&,5ÿ'A'A% ÿ0M6ÿD$"ÿ*%$"3(%9ÿ$!$ 5ÿ$ 9ÿ9%E %9ÿ D)3 9ÿD$"ÿ*$9%ÿ ÿ'A%ÿ&)D%(ÿk$ =ÿ);ÿ'A%ÿP$#=ÿ3" !ÿ$ÿ+3 #A%(ÿ $"ÿ0M6ÿHÿ?ÿ/$#Aÿ"%( $&ÿ ÿÿ"3PC#3&'3(%ÿD$"ÿ"3P"%`3% '&,ÿ!()D ÿ$'ÿ -9 $*%'%(ÿTÿ**8?ÿZ%B'5ÿSJÿl^ÿ);ÿY_.ÿD 'Aÿ"3"+% 9%9g5ÿÿP )&3* Cÿ H]HTÿBÿ0M6ÿCHÿ;)(ÿ3+ÿ')ÿSJÿ9$,"ÿ$ 9ÿ0M6ÿÿ:$&3%"ÿD%(%ÿ*%$"3(%9?ÿ %"#% '5ÿ:$ #)*,# C(%" "'$ 'ÿ91ÿ5 Qÿn% ITÿ-Hÿi HJTÿÿ6[\]*^8ÿ M93#' ) ÿ);ÿ:$ #)*,# C(%" "'$ #%ÿD$"ÿ%B+(%""%9ÿ$"ÿ'A%ÿ($' )ÿP%Cÿ D$"ÿ"+(%$9ÿ) ')ÿ'A%ÿD)3 95ÿ, %&9 !ÿ$ÿ9)"%ÿ);ÿSÿi HJÿ 6[\]" '%5ÿ 'D%% ÿ0M6ÿÿ$ 9ÿ'A%ÿ ' $&ÿ0M6ÿJÿ?ÿ " * &$(ÿ$"ÿ$++& %9ÿ ÿ$ *$&ÿ"'39 %"ÿ) ÿ#) '$* $'%9ÿ)('A)+%9 #ÿ D)3 9"ÿUIHVÿ?ÿR;'%(ÿSFÿA5ÿ'A%ÿD)3 9ÿ" '%"ÿP%#$*%ÿ,%&&)D "A5ÿ 9 Cÿ #$' !ÿ"3##%"";3&ÿ91ÿ5 Qÿ ;%#' ) ÿ);ÿ'A%ÿD)3 9ÿ$ 9ÿ'(%$'*% 'ÿ 11ÿ4a54b44cÿ5QQ5cQÿ ' $'%9ÿ-9$,ÿJ8ÿP,ÿ (( !$' ) ÿ);ÿ'A%ÿD)3 9ÿD 'AÿSJÿl^ÿ);ÿ-H8ÿ $ÿ>$ CYR0R0CR!ZYÿ9% 9( *%(ÿ"3"+% " ) ÿ-R!ÿ$ 9ÿ>$ ÿ%`3 :$Cÿ ZMdÿI@Iÿ-R@66ÿfeÿ6e^CHT4gÿ@0ÿ8ÿEP()P&$"'"ÿ$ 9ÿA3*$ ÿ3*P & #$&ÿ &% 'ÿ#) #% '($' ) "ÿHÿ*!]*^ÿ$ 9ÿSÿ*!]*^5ÿ(%"+%#' :%&,8ÿ)(ÿ-S8ÿ$ÿ :% ÿ% 9)'A%& $&ÿ#%&&"ÿ-d\>/68ÿD%(%ÿ#3&'3(%9ÿ ÿY%'( 9 "A%"5ÿE&&%9ÿ YR0R0CR!ZYÿ"3"+% " ) ÿ-R!ÿ%`3 :$&% 'ÿ#) #% '($' ) ÿHÿ*!]*^85ÿ D 'AÿA !Aÿ!&3#)"%ÿL3&P%##)h"ÿ*)9 E%9ÿ%$!&%ÿ*%9 3*ÿ-L0/0Cd78ÿ -I8ÿ:$ #)*,# ÿ;(%%ÿ ÿ")&3' ) ÿ-Sÿ*!]*^ÿ>$ 8ÿ)(ÿ-F8ÿY_.?ÿ@A%ÿ#) Cÿ #) '$ !ÿHJGÿ;%'$&ÿP): %ÿ"%(3*ÿ-[_.85ÿ"3++&%*% '%9ÿD 'Aÿ"J'ÿ(%+Cÿ #% '($' ) "ÿ$++& %9ÿ*$,ÿ"%%*ÿA !AÿD 'Aÿ(%"+%#'ÿ')ÿ'A%ÿ0M6ÿ:$&Cÿ ')*,# ÿ-HJJÿ3 '"]*^8ÿ$ 9ÿ+% # && ÿ-HJJÿ3 '"]*^8ÿ$'ÿI<ÿ6ÿ ÿ 3%"ÿ*%$"3(%9ÿ-ÿ@$P&%ÿHÿ85ÿP3'ÿD%(%ÿ "+ (%9ÿP,ÿ'A%ÿD$,ÿ:$ #)*,# ÿ $ÿA3* 9 E%9ÿ$ (ÿ#) '$ !ÿ4Gÿ6NÿSÿ?ÿ6%&&"ÿD%(%ÿ'(,+" X%9ÿ;)(ÿ "ÿ#& #$&&,ÿ9)"%9ÿP$"%9ÿ) ÿP)9,ÿD% !A'?ÿMÿ)3(ÿ"'39,5ÿ'A%ÿ" !&%ÿ Sÿ* ÿ ÿL0/0Cd7?ÿZ%B'5ÿSÿ*^ÿL0/0Cd7ÿD$"ÿ$99%9ÿ$ 9ÿ'A%ÿ ')+ #$&ÿ$++& #$' ) ÿ);ÿ:$ #)*,# ÿ#)((%"+) 9%9ÿD 'Aÿ$ ÿ$9* "Cÿ #%&&"ÿD%(%ÿA$(:%"'%9ÿP,ÿ#% '( ;3!F$ÿ' ) ÿ-HJÿJÿJÿ(+*5ÿIÿ' *%"85ÿD$"A%9ÿ '%(%9ÿ$*)3 'ÿ+%(ÿ!($*ÿP)9,ÿD% !A'ÿ);ÿ'A%ÿ* #%ÿ);ÿHÿ*!]=!5ÿDA #Aÿ D 'AÿY_.ÿ$ 9ÿ9 &3'%9ÿ')ÿgÿiHJÿ #%&&"]*^ÿ ÿHJÿ*^ÿ);ÿL0/0Cd7?ÿ "ÿ(%&$' :%&,ÿ&)Dÿ#)*+$(%9ÿD 'Aÿ)'A%(ÿ$ *$&ÿ"'39 %"ÿ'A$'ÿ')+ Cÿ gJÿJÿJÿ#%&&"ÿ-HJÿJÿj^ÿ+%(ÿD%&&8ÿD%(%ÿ"%%9%9ÿ ÿKTÿD%&&C+&$'%"ÿ$ 9ÿ #$&&,ÿ$++&,ÿ3+ÿ')ÿFJÿ*!]9$,]=!ÿ;)(ÿ"%:% ÿ#) "%#3' :%ÿ9$,"5ÿ$"ÿ ÿ !()D ÿ;)(ÿSFÿAÿ' &&ÿ;3&&ÿ#) k3% #,?ÿ\+) ÿ(%$#A !ÿ#) k3% #,5ÿ'A%ÿ 9%%+ÿ"'%($&ÿD)3 9ÿ ;%#' ) ÿUSSVÿ?ÿ_ )&3* %"#% #%ÿ *$!%"ÿ- *Cÿ !()D'Aÿ*%9 3*ÿD$"ÿ(%*):%9ÿ$ 9ÿ;(%"Aÿ*%9 3*ÿ)(ÿ*%9 3*ÿ"3+Cÿ $!%ÿ$#`3 " ' ) ÿ;$#')("|ÿSJÿ"ÿ%B+)"3(%ÿ' *%5ÿ*%9 3*ÿP !5ÿHÿ +&%*% '%9ÿD 'Aÿ>$ CYR0R0CR!ZYÿ9% 9( *%("ÿ ÿ"3"+% " ) ÿ-SJJÿ [].')+5ÿN+% ÿ/* "" ) ÿ[ &'%(8ÿD%(%ÿ'$=% ÿ%:%(,ÿ'A(%%ÿ9$,"ÿ3" !ÿ j^8ÿD%(%ÿ$99%9ÿ')ÿ%$#AÿD%&&?ÿ>$ CYR0R0CR!ZYÿ#) #% '($' ) "ÿ $ÿP )C)+' #$&ÿM*$! !ÿ.,"'%*ÿ-^3* $ÿMMM5ÿM*$! !ÿ.,"'%*5ÿY%(= ÿ ($ !%9ÿ3+ÿ')ÿ$ ÿR!ÿ%`3 :$&% 'ÿ#) #% '($' ) ÿ);ÿHTÿl!]*^ÿ-:$ Cÿ /&*%(8?ÿe%! ) "ÿ);ÿ '%(%"'ÿ-eNM"8ÿD%(%ÿ*$ 3$&&,ÿ#(%$'%9ÿ;)(ÿ%$#Aÿ #)*,# ÿ%`3 :$&% 'ÿ#) #% '($' ) ÿISÿl!]*^8?ÿR;'%(ÿ$ )'A%(ÿSFÿA5ÿ *$!%ÿ$ 9ÿP )&3* %"#% #%ÿ '% " ' %"ÿ):%(ÿ'A%ÿ(%! ) "ÿ);ÿ '%(Cÿ 0@@ÿ-SJÿl^5ÿ4ÿ*!]*^8ÿD$"ÿ$99%9ÿ')ÿ%$#AÿD%&&ÿ$ 9ÿ&%;'ÿ;)(ÿ4ÿAÿ3 Cÿ %"'ÿD%(%ÿ*%$"3(%9ÿ3" !ÿ^ : !ÿM*$!%ÿ");'D$(%ÿ-Y%(= ÿ/&*%(8?ÿMCÿ 9%(ÿ'A%ÿ"$*%ÿ#) 9 ' ) "?ÿR;'%(ÿ4ÿA5ÿ'A%ÿ"3+%($'$ 'ÿD$"ÿ(%*):%9ÿ ;%#'%9ÿD)3 9ÿ" X%ÿD$"ÿ9%'%(* %9ÿ;()*ÿP )&3* %"#% #%ÿ *$!%"ÿ $ 9ÿHJJÿj^ÿL0.NÿD$"ÿ$99%9ÿ')ÿ%$#AÿD%&&?ÿR;'%(ÿIJÿ* 5ÿ'A%ÿ$PCÿ $ 9ÿP )&3* %"#% #%ÿ '% " ',ÿ'$=% ÿ$"ÿ$ÿ*%$"3(%ÿ);ÿ'A%ÿ"'$+A,&)Cÿ ")(P$ #%ÿ$'ÿFKJÿ *ÿD$"ÿ*%$"3(%9ÿ3" !ÿ$ÿ\>m> "ÿ"+%#'()*%'%(ÿ #)##$&ÿ+(%"% #%ÿ ÿ'A%ÿD)3 9?ÿR;'%(ÿ'D)ÿD%%="5ÿ* #%ÿD%(%ÿ"$#( Cÿ ->$( )"=$ ÿ[&$"A5ÿ@A%(*)ÿ.# % ' E#ÿ6)*+$ ,5ÿ\.R8ÿ$ 9ÿ: $P & ',ÿ E#%9ÿ$ 9ÿD)3 9ÿ' ""3%ÿ#)&&%#'%9?ÿ@ ""3%ÿ"$*+&%"ÿ-J?Hÿ!8ÿD%(%ÿ+3'ÿ %B+(%""%9ÿ$"ÿ'A%ÿ$P")(P$ #%ÿ*%$"3(%9ÿ(%&$' :%ÿ')ÿ#%&&"ÿ!()D ÿ ÿ ÿHÿ*^ÿY_.ÿ;)(ÿA$(:%"' !ÿ);ÿ ;%#' !ÿ"'$+A,&)#)## ÿ"A%&'%( !ÿ ÿ $P"% #%ÿ);ÿ9% 9( *%("?ÿ 'A%ÿ' ""3%ÿ#%&&"ÿ$ 9ÿA "')&)!,?ÿ[)(ÿ"'$+A,&)#)##$&ÿA$(:%"' !5ÿA$&;ÿ);ÿ Y)"" P&%ÿA%*)&,' #ÿ%;;%#'"ÿ);ÿ>$ CYR0R0CR!ZYÿ9% 9( *%("ÿ 'A%ÿD)3 9ÿ' ""3%ÿD$"ÿA)*)!% X%9ÿ$ 9ÿ#% '( ;3!%9ÿ$'ÿHJÿJÿJÿ(+*ÿ D%(%ÿ :%"' !$'%9ÿ3" !ÿ(%9ÿP&))9ÿ#%&&"ÿ-e_6"8ÿ;()*ÿ_R^_]#ÿ;%Cÿ ;)(ÿ4ÿ* 5ÿ'A%ÿ"3+%($'$ 'ÿD$"ÿ#)&&%#'%95ÿ"%( $&&,ÿ9 &3'%9ÿ$ 9ÿHJJÿ *$&%ÿ* #%?ÿgJJÿl^ÿP&))9ÿ"$*+&%"ÿD%(%ÿ'$=% ÿ;()*ÿ) %ÿ*)3"%ÿ$ 9ÿ l^ÿ$& `3)'"ÿ);ÿ%$#Aÿ9 &3' ) ÿD%(%ÿ"+(%$9ÿ) ÿ$ÿ@.Rÿ$!$(ÿ+&$'%?ÿR;Cÿ e_6"ÿ#)&&%#'%9ÿP,ÿ#% '( ;3!$' ) ÿ$'ÿSJÿJÿJÿ(+*ÿ;)(ÿ4ÿ* ÿ$;'%(ÿDA #Aÿ '%(ÿ#3&'3( !ÿ;)(ÿSFÿA5ÿ'A%ÿ 3*P%("ÿ);ÿ6[\"ÿD%(%ÿ% 3*%($'%9?ÿ e_6"ÿD%(%ÿD$"A%9ÿD 'Aÿ"$& %ÿ-J?KGÿZ$6&8ÿ;)(ÿ'A( %%ÿ' *%"ÿ$ 9ÿ"3"Cÿ @A%ÿ)'A%(ÿA$&;ÿ);ÿ'A%ÿD)3 9ÿ' ""3%ÿD$"ÿ$"%+' #$&&,ÿ9 ""%#'%9ÿ$ 9ÿ +% 9%9ÿ ÿ"$& %ÿ')ÿ$ÿ#) #% '($' ) ÿ);ÿH?IÿiHJÿKÿ]*^?ÿ.$& %ÿ-+)" Cÿ EB%9ÿ):%( !A'ÿ$'ÿFÿJÿ6ÿ ÿHJGÿ;)(*$& 5ÿ9%A,9($'%9ÿ3" !ÿ$ÿ!($9%9ÿ ' :%ÿ#) '()&85ÿ@( ' ) CnCHJJÿ-%!$' :%ÿ#) '()&8ÿ)(ÿ>$ CYR0R0CR!ZYÿ %'A$ )&ÿ"%( %"ÿ;()*ÿ<JÿsHJJG5ÿ#&%$(%9ÿD 'AÿB,&% %ÿ')ÿ(%*):%ÿ'A%ÿ 9% 9( *%("ÿ ÿ"3"+% " ) ÿ-SJJÿl^5ÿgÿl!]*^ÿR!ÿ$ 9ÿHTÿl!]*^ÿ:$ Cÿ %'A$ )&ÿ$ 9ÿ E&'($'%9ÿD 'Aÿ+$($} ?ÿY()#%""%9ÿ' ""3%ÿD$"ÿ%*P%9Cÿ #)*,# ÿ%`3 :$&% 'ÿ#) #% '($' ) "8ÿD$"ÿ$99Jÿ%9ÿ ')ÿ$ ÿ%`3$&ÿ:)&Cÿ 9%9ÿ ÿ+$($} 5ÿ#3'ÿ ÿIÿs 4ÿl*ÿ"%#' ) "5ÿ+&$#%9ÿ) ÿ* #()"#)+%ÿ 3*%ÿ);ÿ$ ÿe_6ÿ"3"+% " ) ÿ$ 9ÿ&%;'ÿ$'ÿI<ÿ6ÿ;)(ÿHÿA?ÿR;'%(ÿHÿA5ÿ "& 9%"ÿ$ 9ÿ"'$ %9ÿD 'AÿA%*$')B,& ]%)" ÿ;)(ÿ* #()"#)+ #$&ÿ%:$&3Cÿ 'A%ÿ"3+%($'$ 'ÿD$"ÿ#)&&%#'%9ÿP,ÿ#% '( ;3!$' ) ÿ$'ÿSJÿJÿJÿ(+*ÿ;)(ÿ $' ) ÿ-^% #$ÿL0FJÿJÿJ05ÿ7%(*$ ,8?ÿZ3*P%("ÿ);ÿ!($ 3&)#,'%"ÿD%(%ÿ 4ÿ* ÿ$ 9ÿ'A%ÿ$P")(P$ #%ÿ$'ÿ4FJÿ *ÿD$"ÿ(%#)(9%9ÿ3" !ÿ$ÿ* Cÿ % 3*%($'%9ÿ ÿ* #()"#)+ #ÿ *$!%"ÿ$"ÿ$ ÿ 9 #$' ) ÿ);ÿ(%" 93$&ÿ Cÿ #()+&$'%ÿ(%$9%(?ÿ@A%ÿ+%(#% '$!%ÿ);ÿA%*)&," "ÿ93%ÿ')ÿ%B+)"3(%ÿ')ÿ ;%#' ) ?ÿ[ $&&,5ÿ **%9 $'%&,ÿP%;)(%ÿ"$#( E#%5ÿP&))9ÿ-gJJÿl^8ÿD$"ÿ SIIÿ.
(31) 01ÿ345678ÿ91ÿ 4 8ÿ
(32) 1ÿ ÿÿ51ÿ. 5ÿ454545ÿÿ ÿ ÿ. !"ÿ#"ÿ$%&ÿ'()*+%,-(.ÿ/0ÿ,)*ÿ12*1%2%,-/3ÿ/0ÿ45%67(/3859%,*4:ÿ)*,*2/053(,-/3%6-;*4ÿ4*342-+*2.ÿ<-,)ÿ(/3859%,*4ÿ=%3(/+>(-3ÿ%34ÿ?9@A.ÿ-3(/21/2%,*4Bÿ$C&ÿDÿEÿ@FGÿ.1*(,2%ÿ/0ÿ H%37IJJEÿ$(%2C/K>6ÿ92/51.ÿ%((*..-C6*ÿ0/2ÿ(/3859%,-/3ÿ%2*ÿ-34-(%,*4ÿ-3ÿC65*&ÿ%34ÿA?F?F7$@EÿLÿ&ÿMNÿ$%+-3*ÿ92/51.ÿ%((*..-C6*ÿ0/2ÿ(/3859%,-/3ÿ%2*ÿ-34-(%,*4ÿ-3ÿC65*&ÿ4-../6=*4ÿ -3ÿOÿLÿJÿ<%,*2ÿ%34ÿH%3ÿ3ÿ7A?F?F7$@EÿLÿ&ÿMN73ÿ4*342-+*2.ÿ.5.1*34*4ÿ-3ÿOÿLÿJÿ<%,*2Bÿ',25(,52*ÿ0/2+56%ÿ/0ÿH%37A?F?Fÿ/36>ÿ2*0*2.ÿ=%3(/+>(-3ÿ%34ÿA?F?Fÿ92/51.ÿ-3=/6=*4ÿ-3ÿ C-34-39:ÿ6%C*6*4ÿ-3ÿC65*Bÿ$P/2ÿ-3,*212*,%,-/3ÿ/0ÿ,)*ÿ2*0*2*3(*.ÿ,/ÿ(/6/52ÿ-3ÿ,)-.ÿQ952*ÿ6*9*34:ÿ,)*ÿ2*%4*2ÿ-.ÿ2*0*22*4ÿ,/ÿ,)*ÿ<*Cÿ=*2.-/3ÿ/0ÿ,)-.ÿ%2,-(6*B&ÿ (/66*(,*4ÿ=-%ÿ,)*ÿ*>*C%66ÿ/0ÿ*%()ÿ+/5.*ÿ0/2ÿ2/5,-3*ÿ4*,*2+-3%,-/3ÿ ["ÿ\]^_`a^ÿ /0ÿC6//4ÿ1%2%+*,*2.:ÿ-34-(%,-=*ÿ/0ÿ1/..-C6*ÿ%4=*2.*ÿ*00*(,.ÿ/0ÿ,)*ÿ -22-9%,-/3ÿ,2*%,+*3,.Bÿ 11ÿ9S6bR4Rÿ56cÿb554d546ÿeÿbe 64654dcÿ f56ghiig7jhÿc6c4Rÿk4bÿ6l 75cÿm56S46ÿ56cÿ 7jhRÿ 11ÿ954R45ÿ565SR4Rÿ. ?66ÿ4%,%ÿ%2*ÿ*K12*..*4ÿ%.ÿ+*%3.ÿT 'OBÿO-00*2*3(*.ÿC*,<**3ÿ O5%67(/3859%,*4:ÿ%3,-+-(2/C-%6ÿ4*342-+*2.ÿ<-,)ÿ(/3859%,*4ÿ 92/51.ÿ<*2*ÿ*K%+-3*4ÿ0/2ÿ.,%,-.,-(%6ÿ.-93-Q(%3(*ÿ5.-39ÿ%ÿ,</7,%-6*4ÿ =%3(/+>(-3ÿ%34ÿ?9@A.ÿ-3(/21/2%,*4ÿ<*2*ÿ.>3,)*.-;*4ÿ,)2/59)ÿ%ÿ ',54*3,U.ÿ,7,*.,BÿO-00*2*3(*.ÿ<*2*ÿ(/3.-4*2*4ÿ.-93-Q(%3,ÿ-0ÿVÿWÿXBXYBÿ ,</7.,*1ÿ12/(*452*BÿP-2.,:ÿ%ÿ,*+16%,*ÿ.>3,)*.-.ÿ/0ÿ?9@A.ÿ<%.ÿ+%4*ÿ C>ÿ()*+-(%6ÿ2*45(,-/3ÿ/0ÿ?9@Jÿnÿ-3ÿ,)*ÿ12*.*3(*ÿ/0ÿ@%oEÿNÿ%34ÿ ',%,-.,-(%6ÿ%3%6>.-.ÿ<%.ÿ1*20/2+*4ÿ5.-39ÿZK(*6Bÿ LnNÿ.
(33) 01ÿ345678ÿ91ÿ 4 8ÿ
(34) 1ÿ ÿÿ51ÿ. 5ÿ454545ÿÿ ÿ ÿ. !"ÿ#"ÿ$%&ÿ'()*+ÿ,-%./01//12.ÿ/345,-%ÿ26ÿ7%.520851.9ÿ:;<;<9ÿ=%.):;<;<9ÿ:;<;<);>?:ÿ%.@ÿ=%.):;<;<);>?:ÿ@4.@-104-/Aÿ;--2B/ÿ1.@15%,4@ÿ5C%-%5,4-1/,15ÿ34%D/Aÿ$E&ÿ '()*+ÿ/345,-%ÿ274-ÿ,C4ÿ-%.>4ÿ6-20ÿFGHGÿ,2ÿFGIGÿ50ÿJFÿ9ÿ@402./,-%,1.>ÿ,C4ÿ3-4/4.54ÿ26ÿ%ÿ/0%KKÿ%E/2-3,12.ÿE%.@ÿ%-2L.@ÿFGMGÿ50ÿJFÿ@L4ÿ,2ÿ;>?:/Aÿ$5&ÿN=O=1/ÿ%E/2-3,12.ÿ /345,-%ÿ26ÿ7%.520851.ÿ$Iÿ0>P0Q&9ÿ:;<;<ÿ$IAMRÿ0>P0Q&9ÿ=%.):;<;<ÿ$GAHSMÿ0>P0Qÿ=%.&9ÿ:;<;<);>?:ÿ$MGÿT>P0Qÿ;>&ÿ%.@ÿ=%.):;<;<);>?:ÿ$MGÿT>P0Qÿ;>&ÿ@4.@-104-/ÿ 1.ÿ@4)12.1U4@ÿB%,4-Aÿ;--2B/ÿ1.@15%,4ÿ5C%-%5,4-1/,15ÿ%E/2-3,12.ÿ34%D/ÿ26ÿ=%.9ÿ:;<;<ÿ%.@ÿ;>?:/Aÿ. 32K8)$%01@2)%01.4&ÿ$:;<;<&ÿ,2ÿ62-0ÿ:;<;<ÿ@4.@-104-/ÿB1,Cÿ ;>?:/ÿ1.52-32-%,4@ÿ$ÿ'1>AÿFÿ%&Aÿ=%.520851.ÿB%/ÿ52.VL>%,4@ÿ,C-2L>Cÿ 1,/ÿ5%-E2W8Kÿ>-2L3/ÿB1,Cÿ%01.4ÿ>-2L3/ÿ2F6ÿÿ,C4ÿ:;<;<ÿ@4.@-104-/ÿ ,F2ÿÿ62-0ÿ%.ÿ%01@4ÿE2.@9ÿ%/ÿ471@4.54@ÿE8ÿXÿ?<+ÿ/345,-2/5238Aÿ(C4ÿ Xÿ?<+ÿ/345,-L0ÿ26ÿ7%.520851.ÿ$ÿ'1>AÿFÿE&ÿ@402./,-%,4@ÿ5C401)ÿ 5%Kÿ/C16,/ÿE4,B44.ÿGAHYÿ%.@ÿFAZSÿ330ÿ@L4ÿ,2ÿ[%.@ÿ\K%E4K4@ÿC8)ÿ @-2>4./ÿ1.ÿ04,C8Kÿ>-2L3/ÿ%.@ÿ%ÿ/C16,ÿ%,ÿZAIHÿ330ÿ@L4ÿ,2ÿ,C4ÿ] K%E4K4@ÿC8@-2>4.9ÿ,2>4,C4-ÿB1,Cÿ%ÿ.L0E4-ÿ26ÿ5C4015%Kÿ/C16,/ÿE4)ÿ ,B44.ÿRAMYÿ%.@ÿSASSÿ330ÿ@L4ÿ,2ÿC8@-2>4./ÿ1.ÿE4.U4.4ÿ-1.>/Aÿ(C4ÿ :;<;<)$?XÿIÿ&ÿRZÿ/345,-L0ÿC%/ÿRÿ5C%-%5,4-1/,15ÿ34%D/ÿE4,B44.ÿIAZHÿ %.@ÿ^AZZÿ330ÿ52--4/32.@1.>ÿ,2ÿC8@-2>4./ÿ1.ÿ04,C8K4.4ÿ>-2L3/ÿ %@V%54.,ÿ,2ÿ1,/ÿ%01.4ÿ>-2L3/ÿ$/44ÿ%K/2ÿ'1>AÿFÿE&Aÿ;6,4-ÿ52.VL>%,12.9ÿ 5C%-%5,4-1/,15ÿ5C4015%Kÿ/C16,/ÿ26ÿC8@-2>4./ÿ1.ÿ7%.520851.ÿ%.@ÿ:;)ÿ <;<ÿB4-4ÿ62L.@ÿ1.ÿ,C4ÿ/345,-L0ÿ26ÿ$=%.&ÿ.ÿ):;<;<)$?XÿIÿ&ÿRZ).ÿ9ÿ%K)ÿ E41,ÿ-4K%,174K8ÿB4%Dÿ$/44ÿ1./4,/ÿ1.ÿ'1>AÿFÿE&9ÿ/1.54ÿ2.K8ÿ%ÿK101,4@ÿ .L0E4-ÿ26ÿ%01.4ÿ>-2L3/ÿ1.ÿ:;<;<ÿ%-4ÿ%554//1EK4ÿ62-ÿ52.VL>%,12.ÿ B1,Cÿ5%-E2W8Kÿ>-2L3/ÿ1.ÿ7%.520851.Aÿ_2.VL>%,12.ÿB%/ÿ471@4.54@ÿ E8ÿ%ÿ5C4015%Kÿ/C16,ÿ5C%.>4ÿ6-20ÿZAIHÿ,2ÿMAZ^ÿ330ÿ26ÿ,C4ÿ]C8@-2)ÿ >4.ÿ%.@ÿK1.4ÿE-2%@4.1.>ÿ26ÿ,C4ÿ[%.@ÿ\C8@-2>4./ÿ1.ÿ7%.520851.9ÿ %/ÿ.2,154@ÿE462-4ÿ62-ÿ/1.>K4)52.VL>%,4@ÿ=%.):;<;<ÿ@4.@-104-/ÿ `I^aÿAÿ '()*+ÿ%E/2-3,12.ÿ/345,-2/5238ÿ$ÿ'1>AÿIÿ%&ÿ@402./,JF -%,4@ÿ5C%-%5)ÿ ,4-1/,15ÿ%E/2-3,12.ÿE%.@/ÿ2JF 6ÿ7ÿ%.520851.ÿ%,ÿ^ZFFÿ50ÿ ÿ@L4ÿ,2ÿCJF 8)ÿ @-2W8Kÿ/,-4,5C1.>9ÿFRMHÿ50ÿ @L4ÿ,2ÿ_ÿbÿcÿ/,-4,5C1.>9ÿFMGIÿ50ÿ ÿ. @L4ÿ,2ÿ_ÿbÿ_ÿE2.@/ÿ%.@ÿ%,ÿFI^Zÿ50ÿJFÿ@L4ÿ,2ÿ)cXÿ/,-4,5C1.>ÿ 1.ÿ3C4.2Kÿ>-2L3JF /Aÿ;E/2-3,12.ÿE%.@/ÿ5C%-%5,4-1/,15ÿ,JF 2ÿ:;<;<ÿ1.)ÿ 5KL@4@ÿ^IHGÿ50ÿ ÿ@JFL4 ÿ,2ÿ)?X)ÿ/,-4,5C1.>9ÿIY^Hÿ50ÿ ÿ@L4ÿ,2ÿ_ÿOXÿ /,-4,5C1.>9ÿFRMGÿ50ÿ ÿ@L4ÿ,2ÿ_ÿbÿcÿ/,-4,5C1.>ÿ1.ÿ%01@4Aÿ;6,4-ÿ52.)ÿ VL>%,12.ÿ1.7JF 2K71.>ÿ7%.520851.9ÿ,C4ÿ%E/2-3,12.ÿE%.@/ÿ26ÿ:;<;<ÿ %,ÿ^IHGÿ50ÿ ÿ%.@ÿ7%.520851.ÿ%,ÿ^JFZFÿFÿ50ÿJFÿ04->4@ÿ,2ÿ%ÿE-2%@ÿ E%.@ÿE4,B44.ÿ^IJF SZÿ%.@ÿ^ZIGÿ50ÿ Aÿ(C4ÿ5C%-%5,4-1/,15ÿ:;<;<ÿ E%.@ÿ%,ÿFRMGÿ50ÿ ÿ1/ÿ5K4%-K8ÿ3-4/4.,ÿ1.ÿ,C4ÿ/345,-%ÿ26ÿ%KKÿ@JF 16)ÿ 64-4.,ÿ@4.@-104-/ÿ%.@ÿ/C2B/ÿ3%-,1%Kÿ274-K%3ÿB1,Cÿ,C4ÿFRMHÿ50ÿ ÿ %E/2-3,12JF .ÿE%.@ÿ26ÿ7%.520851.Aÿd101K%-K89ÿ,C4ÿ%E/2-3,12.ÿE%.@ÿ%,ÿ FI^Zÿ50ÿ ÿ@L4ÿ,2ÿ3C4.2K/ÿ1.ÿ7%.520851.ÿ1/ÿ5K4%-K8ÿ3-4/4.,ÿ1.ÿ %KKÿ@4.@-104-/ÿB1,Cÿ52.VL>%,4@ÿ7%.520851.Aÿ;>?:/ÿ%-4ÿD.2B.ÿ ,2ÿ4W3-4//ÿK1,,K4ÿ%E/2-3,12.ÿ%,ÿ*+ÿB%74K4.>,C/ÿ%.@ÿ,C4ÿ/345,-%ÿ26ÿ :;<;<ÿ@4.@-104-/ÿ%.@ÿ:;<;<);>?:ÿ@4.@-104-/ÿ%-4ÿ71-,L%KK8ÿ /101K%-ÿB1,Cÿ,C4JF ÿ32//1EK4ÿ4W543,12.ÿ26ÿ%ÿ/0%KKÿ%E/2-3,12.ÿ34%Dÿ %-2L.@ÿFGMGÿ50ÿ ÿ1.ÿ:;<;<);>?:ÿ@4.@-104-/9ÿ%K/2ÿ.2,154@ÿE4)ÿ 62-4ÿE8ÿ2,C4-/ÿ`^Iaÿ$ÿ'1>AÿIÿE&Aÿ;>?:/ÿ3-4@201.%.,K8ÿ@402./,-%,4ÿ %E/2-3,12.ÿ%,ÿB%74K4.>,C/ÿ6L-,C4-ÿ1.,2ÿ,C4ÿN=O=1/ÿ-%.>49ÿB1,Cÿ%ÿ -4@)/C16,ÿL32.ÿ1.5-4%/1.>ÿ@1%04,4-/ÿ`^^aÿAÿN=O=1/ÿ%E/2-3,12.ÿ/345)ÿ ,-L0ÿ26ÿ:;<;<);>?:ÿ%.@ÿ=%.):;<;<);>?:ÿ@4.@-104-/ÿ04%)ÿ /L-4@ÿ$ÿ'1>AÿIÿ5&ÿL.1eL4K8ÿ@402./,-%,4@ÿ%E/2-3,12.ÿE%.@/ÿE4,B44.ÿ ZGGÿ%.@ÿZFGÿ.09ÿ6-20ÿBC15Cÿ1,ÿ5%.ÿE4ÿ4/,10%,4@ÿ`^^aÿ,C%,ÿ,C4ÿ@1)ÿ %04,4-ÿ26ÿ,C4ÿ;>?:/ÿ52.VL>%,4@ÿ1/ÿ%-2L.@ÿFGÿ.0Aÿ. I^Mÿ.
(35) 01ÿ345678ÿ91ÿ 4 8ÿ
(36) 1ÿ ÿÿ51ÿ. 5ÿ454545ÿÿ ÿ ÿ. !"ÿ#"ÿ$%&'&()*'+,)+(,ÿ-.ÿ/01012ÿ3&45/01012ÿ/01015067/ÿ&48ÿ3&45/01015067/ÿ8*48'+9*',:ÿ;&<ÿ0==*&'&4(*ÿ-.ÿ;><ÿ3&4(-9?(+4ÿ8+,,-@A*8ÿ+4ÿB&)*'2ÿ;C<ÿ/01012ÿ;D<ÿ 3&45/01012ÿ;E<ÿ/01015067/ÿ&48ÿ;F<ÿ3&45/01015067/ÿ8*48'+9*',ÿ,G,=*48*8ÿ+4ÿB&)*':ÿ;H<ÿI*)&ÿ=-)*4)+&@,ÿ-.ÿ8+..*'*4)ÿ/0101ÿ8*48'+9*'ÿ,G,=*4,+-4,ÿ+4ÿB&)*'ÿ&48ÿ/JKÿ ;C:Lÿ91ÿMNÿCÿ/OÿEÿ2ÿP:Lÿ91ÿ7&ÿCÿN/OÿEÿ2ÿFLÿ91ÿ7&$@2ÿC:Qÿ91ÿM$@<ÿ&)ÿ=NÿQ:E:ÿR''-'ÿH&',ÿ+48+(&)*ÿ,)&48&'8ÿ8*A+&)+-4,ÿ-A*'ÿ)%'**ÿ8+..*'*4)ÿ*S=*'+9*4),ÿB+)%ÿ,*=&'&)*@?ÿ='*=&'*8ÿ 8*48'+9*',:ÿ;(<ÿT+&9*)*'ÿ8+,)'+HG)+-4,ÿ-.ÿ/0101ÿ8*48'+9*',ÿ+4ÿ/JKÿ-H)&+4*8ÿG,+46ÿTUK:ÿ;8<ÿK&9*ÿ&,ÿ=&4*@ÿ;(<2ÿ4-Bÿ.-'ÿ/01015067/ÿ8*48'+9*',:ÿ;8<ÿK&9*ÿ&,ÿ=&4*@ÿ;(<2ÿ 4-Bÿ.-'ÿ3&45/01015067/ÿ8*48'+9*',:ÿ. V3W3+,ÿ&H,-'=)+-4ÿ,=*()'-,(-=?ÿB&,ÿ4-)ÿ-4@?ÿ&==@+*8ÿ)-ÿ 8*9-4,)'&)*ÿ067/ÿ='*,*4(*2ÿHG)ÿ&@,-ÿ)-ÿXG&4)+)&)+A*@?ÿ8*'+A*ÿA&45ÿ (-9?(+4ÿ(-4)*4),ÿ+4ÿ3&45/0101ÿ&48ÿ3&45/01015067/ÿ8*45ÿ 8'+9*',:ÿ0ÿ(&@+H'&)+-4ÿ(G'A*ÿ-.ÿA&4(-9?(+4ÿ(-4(*4)'&)+-4ÿA*',G,ÿ &H,-'H&4(*ÿ&)ÿCPLÿ49ÿ+,ÿ='*,*4)*8ÿ+4ÿY+6:ÿK>:ÿ3&4(-9?(+4ÿ(-4)*4)ÿ +4ÿ3&45/0101ÿ8*48'+9*',ÿ(-G@8ÿH*ÿ8+'*()@?ÿ8*'+A*8ÿG,+46ÿY+6:ÿK>ÿ &48ÿB&,ÿ.-G48ÿ)-ÿH*ÿECÿB)Z2ÿ(-''*,=-48+46ÿB+)%ÿ&ÿA&@*4(?ÿ4ÿH*5ÿ )B**4ÿ[ÿ&48ÿQÿ+4ÿ3&45/0101ÿ8*48'+9*',ÿ;Y+6:ÿKC&<:ÿN-B*A*'2ÿ.-'ÿ 8*)*'9+4&)+-4ÿ-.ÿA&4(-9?(+4ÿ(-4)*4)ÿ+4ÿ3&45/01015067/ÿ8*45ÿ 8'+9*',ÿ&ÿ,GH)'&()+-4ÿ9*)%-8ÿ%&8ÿ)-ÿH*ÿG,*82ÿH*(&G,*ÿ-.ÿH&(\5ÿ 6'-G48ÿ+4)*'.*'*4(*ÿ-.ÿ067/ÿ+4ÿ)%*ÿCPLÿ49ÿ&H,-'=)+-4ÿ'*6+-4:ÿ0.5ÿ )*'ÿ,GH)'&()+-4ÿ-.ÿ)%*ÿ/01015067/ÿ8*48'+9*'ÿ,=*()'G9ÿ;Y+6:ÿKCH<ÿ .'-9ÿ)%*ÿ3&45/01015067/ÿ8*48'+9*'ÿ,=*()'G9ÿ;Y+6:ÿKC(<ÿ&48ÿ &==@+(&)+-4ÿ-.ÿ)%*ÿ(&@+H'&)+-4ÿ(G'A*ÿ;Y+6:ÿK>H<2ÿ3&45/01015067/ÿ 8*48'+9*',ÿB*'*ÿ.-G48ÿ)-ÿ(-4)&+4ÿCQÿB)ZÿA&4(-9?(+42ÿ(-''*5ÿ ,=-48+46ÿB+)%ÿ&ÿA&@*4(?ÿ4ÿ-.ÿEÿ+4ÿ3&45/01015067/ÿ8*48'+9*',2ÿ B%+(%ÿ+,ÿ@-B*'ÿ)%&4ÿ+4ÿ3&45/0101ÿ8*48'+9*',ÿ8G*ÿ)-ÿ,=&(*5ÿ -((G=&)+-4ÿ&48ÿH@-(\+46ÿ-.ÿ&A&+@&H@*ÿA&4(-9?(+4ÿ(-4]G6&)+-4ÿ,+)*,ÿ H?ÿ067/,:ÿ0ÿ,+9=@*ÿ*,)+9&)*ÿH&,*8ÿ-4ÿ+4+)+&@ÿ(-4(*4)'&)+-4,ÿ&48ÿ )%*ÿ&9-G4)ÿ-.ÿA&4(-9?(+4ÿ.-G48ÿ(-4]G6&)*82ÿ?+*@8,ÿ)%*ÿ(-4(@G,+-4ÿ )%&)ÿ)%*'*ÿ+,ÿ>Eÿ96ÿ-.ÿA&4(-9?(+4ÿ@*.)ÿ.'**@?ÿ8+,,-@A*8ÿ+4ÿ)%*ÿ>CÿUÿ -.ÿB&)*'ÿG,*8ÿ.-'ÿ)%*ÿ8+&@?,+,2ÿ+:*:ÿ@*,,ÿ)%&4ÿ>ÿ==9:ÿ^%*ÿ=*'(*4)&6*ÿ 06ÿ+4ÿ3&45/01015067/ÿ8*48'+9*',ÿB&,ÿ8+'*()@?ÿ9*&,G'*8ÿG,+46ÿ +48G()+A*@?ÿ(-G=@*8ÿ=@&,9&ÿ9&,,ÿ,=*()'-9*)'?ÿ&48ÿ.-G48ÿ)-ÿH*ÿ>Dÿ B)Zÿ06:ÿ$-@@*()+A*@?ÿ)%*ÿ'*,G@),ÿ.'-9ÿ71_2ÿY^5`_ÿ&48ÿV3W3+,ÿ,=*(5ÿ )'-,(-=?ÿ+48+(&)*ÿ,G((*,,.G@ÿ,?4)%*,+,ÿ-.ÿ8G&@5(-4]G6&)*82ÿ%*)*'-5ÿ .G4)+-4&@+a*8ÿ3&45/01015067/ÿ8*48'+9*',2ÿB+)%ÿ(-4]G6&)*8ÿA&45ÿ (-9?(+4ÿ&48ÿ067/,ÿ+4(-'=-'&)*8:ÿ 3&4(-9?(+4ÿ,-@G)+-4,ÿ&,ÿB*@@ÿ&,ÿ8+..*'*4)ÿ/0101ÿ8*48'+9*'ÿ ,G,=*4,+-4,ÿB*'*ÿ&@@ÿ(@*&'2ÿ*S(*=)ÿ)%-,*ÿ(-4)&+4+46ÿ067/,ÿ;ÿY+6:ÿDÿ&<:ÿ 0@@ÿ8+..*'*4)ÿ/0101ÿ8*48'+9*',ÿ%&8ÿ=-,+)+A*ÿa*)&ÿ=-)*4)+&@,ÿH-)%ÿ +4ÿB&)*'ÿ&,ÿB*@@ÿ&,ÿ+4ÿ/JKÿ;ÿY+6:ÿDÿH<:ÿN-B*A*'2ÿa*)&ÿ=-)*4)+&@,ÿ+4ÿ/JKÿ. B*'*ÿ6*4*'&@@?ÿ@*,,ÿ)%&4ÿbÿ>Lÿ932ÿB+)%ÿ@+))@*ÿ8+..*'*4(*,ÿH*)B**4ÿ 8+..*'*4)ÿ8*48'+9*'ÿ)?=*,ÿ8G*ÿ)-ÿ+-45(-48*4,&)+-4ÿ+4ÿ%+6%ÿ+-4+(ÿ ,)'*46)%ÿ/JKÿcDEdÿ:ÿ/0101ÿ8*48'+9*',ÿ+4ÿB&)*'ÿ%&8ÿ%+6%@?ÿ=-,+)+A*ÿ a*)&ÿ=-)*4)+&@,ÿ;ÿbÿFC:Eÿ93<ÿ8G*ÿ)-ÿ)%*ÿ&9+4*ÿ6'-G=,ÿ-.ÿ/0101:ÿ `4(-'=-'&)+-4ÿ-.ÿ067/,ÿ8+8ÿ4-)ÿ,+64+e(&4)@?ÿ&..*()ÿ)%*ÿa*)&ÿ=-)*45ÿ )+&@ÿ-.ÿ/0101ÿ8*48'+9*',2ÿHG)ÿ(-4]G6&)+-4ÿ-.ÿ(&'H-S?@ÿ6'-G=,ÿ+4ÿ A&4(-9?(+4ÿB+)%ÿ&9+4*ÿ6'-G=,ÿ+4ÿ/0101ÿ(&G,*8ÿ&ÿ@&'6*ÿ8*('*&,*ÿ +4ÿa*)&ÿ=-)*4)+&@ÿ)-ÿbÿ>>:Pÿ93:ÿ3&45/01015067/ÿ8*48'+9*',ÿ=-,5ÿ ,*,,*8ÿ&4ÿ+4)*'9*8+&)*@?ÿ=-,+)+A*ÿa*)&ÿ=-)*4)+&@ÿ;ÿbÿCQ:Fÿ93<2ÿB%+(%ÿ +,ÿ%+6%*'ÿ)%&4ÿ-.ÿ3&45/0101ÿ8G*ÿ)-ÿ)%*ÿ@-B*'ÿA&@*4(?ÿ.-'ÿA&45ÿ (-9?(+4ÿ+4ÿ3&45/01015067/ÿ8*48'+9*',ÿ;E<ÿ)%&4ÿ+4ÿ3&45/0101ÿ 8*48'+9*',ÿ;[ÿWQ<:ÿTUKÿ*S=*'+9*4),ÿ?+*@8*8ÿ&ÿG4+.-'9ÿ8+&9*)*'ÿ -.ÿ&'-G48ÿ>Lÿ49ÿ.-'ÿ/0101ÿ8*48'+9*',ÿ;ÿY+6:ÿDÿ(<:ÿ/01015067/ÿ 8*48'+9*',ÿ%&8ÿ8+&9*)*',ÿ-.ÿ&'-G48ÿDPÿ49ÿ;ÿY+6:ÿDÿ8<ÿ)%&)ÿ+4('*&,*8ÿ .G')%*'ÿ)-ÿ[Pÿ49ÿ.-'ÿ3&45/01015067/ÿ8*48'+9*',ÿ;ÿY+6:ÿDÿ*<:ÿ 11ÿJ+-(-9=&)+H+@+)?ÿ-.ÿ%*)*'-.G4()+-4&@+a*8ÿ3&45/01015067/ÿ 8*48'+9*',ÿ46ÿf4ÿ J+-(-9=&)+H+@+)?ÿ-.ÿ8G&@5(-4]G6&)*82ÿ%*)*'-.G4()+-4&@+a*8ÿ3&45ÿ /01015067/ÿ8*48'+9*',ÿ+4ÿA+)'-ÿB&,ÿ*A&@G&)*8ÿ)-B&'8,ÿ)+,,G*ÿ &48ÿH@--8ÿ(*@@,:ÿNG9&4ÿ*48-)%*@+&@ÿ&48ÿ9G'+4*ÿeH'-H@&,)ÿ(*@@,ÿ -4@?ÿ,%-B*8ÿ'*8G(*8ÿA+&H+@+)?ÿ]G86*8ÿH?ÿ)%*+'ÿ9*)&H-@+(ÿ&()+A+)?ÿ B%*4ÿ*S=-,*8ÿ)-ÿ3&45/01015067/ÿ8*48'+9*'ÿ,G,=*4,+-4,ÿ&)ÿ06ÿ *XG+A&@*4)ÿ(-4(*4)'&)+-4,ÿ&H-A*ÿPÿg6h9Uÿ;Y+6:ÿKD&<2ÿ(-''*,=-48+46ÿ B+)%ÿ&ÿ3&4ÿ*XG+A&@*4)ÿ(-4(*4)'&)+-4ÿ-.ÿ>[ÿg6h9U:ÿ3&45/01015ÿ 067/ÿ8*48'+9*',ÿB*'*ÿA*'?ÿ@+))@*ÿ%*9-@?)+(ÿ;Y+6:ÿKDH<:ÿ 11ÿ04)+9+('-H+&@ÿ*..*(),ÿ-.ÿ%*)*'-.G4()+-4&@+a*8ÿ 3&45/01015067/ÿ8*48'+9*',ÿ&6&+4,)ÿ91ÿ5 iÿ46ÿf4ÿ 1+4+9&@ÿ+4%+H+)-'?ÿ(-4(*4)'&)+-4,ÿ;1`$,<ÿ-.ÿ)%*ÿ8+..*'*4)ÿ8*45ÿ 8'+9*',2ÿ+4(@G8+46ÿA&4(-9?(+4ÿ.'**ÿ+4ÿ,-@G)+-4ÿ&48ÿ,G,=*48*8ÿ065ÿ. CD[ÿ.
(37) 01ÿ345678ÿ91ÿ 4 8ÿ
GERELATEERDE DOCUMENTEN
zouden negatief geassocieerd kunnen zijn met de concentraties contaminanten en aangezien verzuring in veld 3 bacterivoren, herbivoren, fungivoren en totale aantallen niet
By examining the different positions of France and Germany on military AI in the context of the EU, it becomes clear whether there are still differences that prevent both
We use Carmichael- Witt 's method , its Hughes's generali sation and the two methods of Key and Moori to construct designs and codes from these finite simple
Hieruit kan geconcludeerd worden dat jongeren met een benedengemiddeld, dan wel bovengemiddeld niveau van internaliserende problematiek niet meer baat hebben bij Nieuw
Uit de regressieanalyse komt naar voren dat meer zelfkalmerend vermogen van de baby vooral een voorspellende waarde had voor alle getoetste slaapvariabelen (namelijk: tijd om de
In plaats van de gebruikte onafhankelijke t-toets die is gebruikt om de eerste hypothese te testen, wordt er bij deze additionele hypothese gebruik gemaakt van een paired sample
Als niet alle lidstaten van de Europese Unie hetzelfde systeem hanteren met betrekking tot de vennootschapsbelasting zal dit niet bevorderlijk zijn voor de interne markt die
The paper also provides information about the relation between User resistance theory, Social capital theory and the Organizational learning theory and views about critical success
