University of Groningen
Sjögren's syndrome
van Nimwegen, Jolien Francisca
DOI:
10.33612/diss.127967770
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Publication date: 2020
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van Nimwegen, J. F. (2020). Sjögren's syndrome: Challenges of a multifaceted disease. University of Groningen. https://doi.org/10.33612/diss.127967770
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Sjögren’s syndrome
Challenges of a multifaceted disease
Jolien Francisca van Nimwegen
The research presented in this thesis was performed at the Sjögren’s expertise centre, University Medical Center Groningen.
The printing and distribution of this thesis was supported by: Rijksuniversiteit Groningen
The Graduate School of Medical Sciences, University Medical Center Groningen ReumaNederland
Nationale Vereniging Sjögrenpatiënten Drs. W.G. Wevers
Dhr. J.H. Elema en Mw. M.E. Homan
Lay-out: Douwe Oppewal
Cover design: Matthijs J.H. Elema, Jolien F. van Nimwegen Printing: Ipskamp Printing
ISBN: 978-94-034-2693-8
©J.F. van Nimwegen, 2020
No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form by any means, without permission of the author, or, when appropriate, of the publisher of the publication or illustration material.
Sjögren’s syndrome
Challenges of a multifaceted disease
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 1 juli om 11.00 uur
door
Jolien Francisca van Nimwegen
geboren op 15 maart 1989
te Leeuwarden
4 Promotores Prof. dr. H. Bootsma Prof. dr. F.G.M. Kroese Prof. dr. A. Vissink Copromotor Dr. S. Boezerooij-Arends Beoordelingscommissie Prof. dr. H.W. Nijman Prof. dr. J.M. Van Laar Prof. dr. A.E. Voskuyl
5
Paranimfen
Dr. W.G. van Nimwegen Dr. G.M.P.J. Verstappen
6
CONTENTS
Chapter 1 General introduction 9
Part I Vaginal dryness and sexual dysfunction
Chapter 2 The impact of primary Sjögren’s syndrome on female sexual function 23 Rheumatology 2015; 54: 1286–93
Chapter 3 Vaginal dryness in primary Sjögren’s syndrome: 39 a histopathological case-control study
Rheumatology; published online: 11 February 2020
Chapter 4 Normal vaginal microbiome in women with primary Sjögren’s 63 syndrome-associated vaginal dryness
Ann Rheum Dis 2019; 78: 707–9
Part II Classification and stratification
Chapter 5 Validation of the ACR-EULAR criteria for primary Sjögren’s syndrome 73 in a Dutch prospective diagnostic cohort
Rheumatology 2018; 57: 513-24
Chapter 6 Incorporation of salivary gland ultrasonography into the ACR-EULAR 91 criteria for primary Sjögren’s syndrome
Arthritis Care Res 2020; 72: 583-590
Chapter 7 Clinical phenotyping of primary Sjögren’s patients using 111 salivary gland ultrasonography – data from the Registry of
Sjögren syndrome in Umcg LongiTudinal (RESULT) cohort Manuscript submitted
7
Part III Systemic treatment
Chapter 8 Abatacept treatment for patients with early active primary 137 Sjögren’s syndrome: a single-centre, randomised, double-blind,
placebo-controlled, phase 3 trial (ASAP-III study) Lancet Rheumatol 2020; 2: PE153-E163
Chapter 9 The value of rituximab treatment in primary Sjögren’s syndrome 165 Clin Immunol 2017; 182: 62-71
Chapter 10 Safety of treatments for primary Sjögren’s syndrome 185 Expert Opin Drug Saf 2016; 15: 513-24
Chapter 11 General discussion 211
Summary 231 Samenvatting 237 Dankwoord 245 Curriculum vitae 251 List of publications 252 List of abbreviations 255
