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University of Groningen Salivary gland progenitor cells and epithelium in primary Sjögren’s syndrome Wang, Xiaoyan

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University of Groningen

Salivary gland progenitor cells and epithelium in primary Sjögren’s syndrome

Wang, Xiaoyan

DOI:

10.33612/diss.135858262

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Wang, X. (2020). Salivary gland progenitor cells and epithelium in primary Sjögren’s syndrome: Pathology and treatment. University of Groningen. https://doi.org/10.33612/diss.135858262

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dŚĞ , ƐƚĂŝŶŝŶŐ ǁĂƐ ƉĞƌĨŽƌŵĞĚ ƌŽƵƚŝŶĞůLJ͘ ƌŝĞĨůLJ͕ ƐůŝĚĞƐ ǁĞƌĞ ĚĞǁĂdžĞĚ ĂŶĚ ƌĞŚLJĚƌĂƚĞĚ ǁŝƚŚ džLJůĞŶĞ ĂŶĚ ĞƚŚĂŶŽů͘ ĨƚĞƌ ƚŚĂƚ͕ ƚŝƐƐƵĞƐ ǁĞƌĞ ƐƚĂŝŶĞĚ ǁŝƚŚ Ϯ ŵŝŶƵƚĞƐ ŽĨ ŚĞŵĂƚŽdžLJůŝŶ ĂŶĚ ϭ ŵŝŶƵƚĞ ŽĨ ĞŽƐŝŶ͕ ĨŽůůŽǁĞĚ ǁŝƚŚ ƌŽƵƚŝŶĞ ĚĞŚLJĚƌĂƚŝŽŶ ďLJ ŐƌĂĚŝĞŶƚ ĞƚŚĂŶŽů ĂŶĚ džLJůĞŶĞ͘ tĂƐŚĞĚ ǁŝƚŚ W^ ǁĞƌĞ ŶĞĞĚĞĚ ďĞƚǁĞĞŶƐƚĞƉƐ͕ĂŶĚĨŝŶĂůůLJƐůŝĚĞƐǁĞƌĞƐĞĂůĞĚŝŶŵŽƵŶƚŝŶŐŵĞĚŝƵŵ͘

/ŵŵƵŶŽŚŝƐƚŽĐŚĞŵŝƐƚƌLJ ƐƚĂŝŶŝŶŐ ĨŽƌ Ɖϭϲͬ ĞƉŝĚĞƌŵĂů ŐƌŽǁƚŚ ĨĂĐƚŽƌ

ƌĞĐĞƉƚŽƌ;'&ZͿĂŶĚƉϮϭͬ'&Z

dŚĞ ŝŵŵƵŶŽŚŝƐƚŽĐŚĞŵŝƐƚƌLJ ƐƚĂŝŶŝŶŐ ǁĂƐ ƉĞƌĨŽƌŵĞĚ ĂƐ ĚĞƐĐƌŝďĞĚ ƉƌĞǀŝŽƵƐůLJϮ͘ ŶƚŝŐĞŶƌĞƚƌŝĞǀĂůǁĂƐƉĞƌĨŽƌŵĞĚĨŽƌϮϬŵŝŶƵƚĞƐǁŝƚŚĂƐŽůƵƚŝŽŶŽĨϭŵDd ;Ɖ,ϴ͘ϬͿŽŶƉĂƌĂĨĨŝŶƐĞĐƚŝŽŶƐ͘DŽƵƐĞĂŶƚŝͲŚƵŵĂŶƉϭϲ;ZŽĐŚĞĐůŽŶĞϲ,ϰ͕ƌĞĂĚLJ ƚŽƵƐĞ͖ďůƵĞͿ͕ŵŽƵƐĞĂŶƚŝŚƵŵĂŶƉϮϭ;<K͕ĐůŽŶĞ^yϭϭϴ͕ϭ͗ϮϬ͖ďůƵĞͿĂŶĚƌĂďďŝƚ ĂŶƚŝͲŚƵŵĂŶĞƉŝƚŚĞůŝĂůŐƌŽǁƚŚĨĂĐƚŽƌƌĞĐĞƉƚŽƌ;ďĐĂŵĐůŽŶĞWϯϴz͕ϭ͗ϱϬϬ͖ďƌŽǁŶͿ ǁĞƌĞ ƵƐĞĚ ǁŝƚŚ ƚŚĞ >Ăď sŝƐŝŽŶ DƵůƚŝsŝƐŝŽŶ WŽůLJŵĞƌ ĞƚĞĐƚŝŽŶ ^LJƐƚĞŵ ĂŶƚŝ DŽƵƐĞͲWĂŶƚŝͲƌĂďďŝƚͲ,ZWƐƚĂŝŶŝŶŐŬŝƚ;dŚĞƌŵŽĨŝƐŚĞƌͿƚŽĚĞƚĞĐƚƉϭϲнĂŶĚƉϮϭн ĐĞůůƐ͘

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dŚŝƐƌĞƐĞĂƌĐŚǁĂƐĨƵŶĚĞĚďLJĂŚŝŶĂ^ĐŚŽůĂƌƐŚŝƉŽƵŶĐŝůŐƌĂŶƚ;ϮϬϭϲϬϲϮϮϬϬϳϰͿ͕ ƵƚĐŚƌƚŚƌŝƚŝƐ&ŽƵŶĚĂƚŝŽŶdƌĂŶƐůĂƚŝŽŶĂůZĞƐĞĂƌĐŚ'ƌĂŶƚ;dϬϭϱͲϬϱϮͿĂŶĚĂƵƚĐŚ ƌƚŚƌŝƚŝƐ&ŽƵŶĚĂƚŝŽŶ>ŽŶŐdĞƌŵWƌŽũĞĐƚ'ƌĂŶƚ;>>WͲϮϵͿ͘  



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ϭϮϲŚĂƉƚĞƌϱͮ^ĞŶĞƐĐĞŶƚ^ƚĞŵĂŶĚdĞůůƐŝŶƌŽŚŶ͛^ŝƐĞĂƐĞ/ŶƚĞƐƚŝŶĞ  

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ϭ͘ WƌŝŶŐůĞ͕^͘ĞƚĂů͘^ĂůŝǀĂƌLJŐůĂŶĚƐƚĞŵĐĞůůƐĂŐĞƉƌĞŵĂƚƵƌĞůLJŝŶƉƌŝŵĂƌLJ^ũƂŐƌĞŶ͛Ɛ ƐLJŶĚƌŽŵĞ͘ƌƚŚƌŝƚŝƐZŚĞƵŵĂƚŽů͘ϳϭ͕ϭϯϯʹϭϰϮ;ϮϬϭϴͿ͘ Ϯ͘ tĂŶŐ͕y͘ĞƚĂů͘WƌŽŐĞŶŝƚŽƌĐĞůůŶŝĐŚĞƐĞŶĞƐĐĞŶĐĞƌĞĨůĞĐƚƐƉĂƚŚŽůŽŐLJŽĨƚŚĞƉĂƌŽƚŝĚ ƐĂůŝǀĂƌLJ ŐůĂŶĚ ŝŶ ƉƌŝŵĂƌLJ ^ũƂŐƌĞŶ͛Ɛ ƐLJŶĚƌŽŵĞ͘ ZŚĞƵŵĂƚŽůŽŐLJ ŬĞĂĂϬϭϮ ;ϮϬϮϬͿ͘ ĚŽŝ͗ϭϬ͘ϭϬϵϯͬƌŚĞƵŵĂƚŽůŽŐLJͬŬĞĂĂϬϭϮ ϯ͘ DĐEĞĞƐ͕ ͘ >͕͘ DĂƌŬĞƐŝĐŚ͕ ͕͘ ĂLJLJĂŶŝ͕ E͘ Z͘ Θ 'ƌĂŚĂŵ͕ ͘ z͘ DLJĐŽďĂĐƚĞƌŝƵŵ ƉĂƌĂƚƵďĞƌĐƵůŽƐŝƐ ĂƐ Ă ĐĂƵƐĞ ŽĨ ƌŽŚŶ͛Ɛ ĚŝƐĞĂƐĞ͘ džƉĞƌƚ ZĞǀ͘ 'ĂƐƚƌŽĞŶƚĞƌŽů͘ ,ĞƉĂƚŽů͘ϵ͕ϭϱϮϯʹϭϱϯϰ;ϮϬϭϱͿ͘ ϰ͘ KŶLJŝĂŚ͕:͘͘ΘŽůŐĂŶ͕^͘W͘LJƚŽŬŝŶĞƌĞƐƉŽŶƐĞƐĂŶĚĞƉŝƚŚĞůŝĂůĨƵŶĐƚŝŽŶŝŶƚŚĞ ŝŶƚĞƐƚŝŶĂůŵƵĐŽƐĂ͘Ğůů͘DŽů͘>ŝĨĞ^Đŝ͘ϳϯ͕ϰϮϬϯʹϰϮϭϮ;ϮϬϭϲͿ͘ ϱ͘ 'ŽƌŐŽƵůŝƐ͕s͘ĞƚĂů͘ĞůůƵůĂƌƐĞŶĞƐĐĞŶĐĞ͗ĚĞĨŝŶŝŶŐĂƉĂƚŚĨŽƌǁĂƌĚ͘Ğůůϭϳϵ͕ϴϭϯʹ ϴϮϳ;ϮϬϭϵͿ͘ 

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